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Method for removing residual pharmaceutical ingredients in oxytetracycline pharmaceutical dregs by ultrasonic wave

A technology for residual drugs and oxytetracycline, which is applied in the removal of solid wastes, etc., can solve the problems of high process conditions, high concentration of hydrochloric acid, and complicated processes, and achieves fast treatment process, no secondary pollution, and mild degradation conditions. Effect

Inactive Publication Date: 2012-07-11
HEBEI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process conditions are demanding, the process is complicated and the cycle is long, and the waste residue after protein removal needs to be treated
The other is to use chemical methods to treat the dregs of oxytetracycline (ZL200710185390.4), which takes a long time, the concentration of hydrochloric acid is high, and the amount is large, and methanol is used in the treatment process, so there will inevitably be methanol residues

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take 50 grams of wet dregs of oxytetracycline in a beaker, place in a water bath and heat to 70°C-75°C for 10 minutes, add 25mL of 0.5mol / L hydrochloric acid solution after cooling to room temperature, stir and mix evenly, measure the pH to 0.5; The uniform dregs are placed in an ultrasonic instrument, at an ultrasonic frequency of 20kHz and a sound intensity of 1W / cm 2 After processing for 30 minutes, centrifuge and filter, recover the filtrate and reuse it as a pH regulator, adjust the pH value of the filter residue to 4.5 with calcium oxide, and dry it in a drying oven at 90°C for 30 minutes; After treatment, the residual oxytetracycline content decreased from 0.57% to 0.07%, the removal rate was 87.7%, and the crude protein content decreased from 40.3% to 36.9%, a decrease of 8.4%.

Embodiment 2

[0024] Take 50 grams of wet dregs of oxytetracycline in a beaker, place in a water bath and heat to 70°C-75°C for 20 minutes, add 20mL of 0.5mol / L hydrochloric acid solution after cooling to room temperature, stir and mix evenly, and measure the pH to 0.6; The uniform dregs are placed in an ultrasonic instrument, and the ultrasonic frequency is 40kHz and the sound intensity is 2W / cm 2 After processing for 10 minutes, centrifuge and filter, recover the filtrate and reuse it as a pH regulator, adjust the pH value of the filter residue to 4.5 with calcium oxide, and dry it in a drying oven at 90°C for 30 minutes; After the treatment of oxytetracycline dregs, the residual oxytetracycline content decreased from 0.57% to 0.055%, the removal rate was 90.3%, and the crude protein content decreased from 40.3% to 36.9%, a decrease of 8.4%.

Embodiment 3

[0026] Take 50 grams of wet dregs of oxytetracycline in a beaker, place in a water bath and heat to 70°C-75°C for 10 minutes, add 1mL of 0.5mol / L hydrochloric acid solution after cooling to room temperature, stir and mix evenly, and measure the pH to 0.8; The uniform dregs are placed in an ultrasonic instrument, at an ultrasonic frequency of 80kHz and a sound intensity of 3.5W / cm 2 After processing for 20 minutes, centrifuge and filter, recover the filtrate and reuse it as a pH regulator, adjust the pH value of the filter residue to 4.5 with calcium oxide, and dry it in a drying oven at 90°C for 30 minutes; After the treatment of oxytetracycline dregs, the residual oxytetracycline content decreased from 0.57% to 0.06%, the removal rate was 89.5%, and the crude protein content decreased from 40.3% to 36.9%, a decrease of 8.4%.

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Abstract

The invention discloses a method for removing residual pharmaceutical ingredients in oxytetracycline pharmaceutical dregs by ultrasonic wave, comprising the following steps of: A, heating up oxytetracycline wet pharmaceutical dregs to solidify protein, so that the protein is not influenced by ultrasonic wave; B, cooling the oxytetracycline wet pharmaceutical dregs into normal temperature, adjusting the pH of the oxytetracycline wet pharmaceutical dregs into 0.5-1.0 by hydrochloric acid, and evenly stirring the wet pharmaceutical dregs; and C, putting the evenly-stirred wet pharmaceutical dregs into a container with normal pressure and ultrasonic environment to carry out ultrasonic wave radiation, and degrading and invalidating the oxytetracycline ingredient in the wet pharmaceutical dregs by the acoustic cavitation effect of the ultrasonic wave. The method is quick, low-cost and environment-friendly to treat the oxytetracycline pharmaceutical dregs, and is good in treatment effect, so that the obtained product is heavy in weight and high in use value.

Description

technical field [0001] The invention relates to the technical field of industrial solid waste recycling, reduction and comprehensive utilization, in particular to a method for eliminating residual drug components in oxytetracycline dregs by using ultrasonic waves. Background technique [0002] Oxytetracycline is a broad-spectrum antibiotic, a product of microbial fermentation, which has a strong antibacterial effect on some Gram-positive bacteria, negative bacteria, and Rickettsia. Oxytetracycline is an amphoteric compound, which is prone to denaturation reactions under acid and alkali conditions. At present, the production process of oxytetracycline in China mainly includes two parts: fermentation and extraction. The microbial fermentation process uses nearly 10 kinds of organic substances such as starch, soybean powder cake, and dextrin as raw materials, which are used as carbon sources and energy for microbial synthesis; the extraction process is made of oxalic acid. Aci...

Claims

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Application Information

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IPC IPC(8): B09B3/00
Inventor 闫正程琛李庆李文昭杨敬伟陈伟龙张小彬孙宏丽
Owner HEBEI UNIVERSITY
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