Tinidazole ophthalmic gel, and preparation method and application thereof

A tinidazole ophthalmic and ophthalmic gel technology, which is applied in the fields of pharmaceutical formulation, drug delivery, oil/fat/wax non-active ingredients, etc., can solve the problem of low curative effect, short residence time in conjunctival sac, and tinidazole-free ocular Use gel research and reports on pharmaceutical production to achieve the effects of long residence time, prominent substantive features, and large social and economic benefits

Inactive Publication Date: 2012-07-18
段亚东
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ordinary metronidazole eye drops have short residence time in conjunctival sac and low curative effect
At present, there are no ophthalmic preparations on the domestic market that can kill Demodex mites and Acanthamoeba, and there is no report on the research and production of tinidazole ophthalmic gel.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Prescription composition: tinidazole 0.75g, carbomer 0.8g, hydroxypropyl methylcellulose 0.2g, hydrogenated hard castor oil 1.0g, boric acid 1.0g, propylene glycol 1.0g, sodium chloride 0.5g, ethylparaben 0.025 g, add water for injection to the full amount to make 100g tinidazole ophthalmic gel.

[0020] Preparation method: Dissolve tinidazole with an appropriate amount of water for injection, stir with hydroxypropyl methylcellulose, hydrogenated hard castor oil, boric acid, propylene glycol, sodium chloride, and ethylparaben respectively, and heat to dissolve completely to form Tinidazole solution: carbomer is sprinkled in water for injection, swollen into a gel solution, added to the tinidazole solution, autoclaved, cooled, filtered, subpackaged and packaged to obtain the product.

Embodiment 2

[0022] Prescription composition: tinidazole 0.5g, carbomer 0.8g, hydroxypropyl methylcellulose 0.2g, hydrogenated hard castor oil 1.0g, boric acid 1.0g, propylene glycol 1.0g, sodium chloride 0.5g, ethylparaben 0.025 g, add water for injection to the full amount to make 100g tinidazole ophthalmic gel.

[0023] Preparation method: with embodiment 1.

Embodiment 3

[0025] Prescription composition: tinidazole 1.0g, carbomer 0.8g, hydroxypropyl methylcellulose 0.2g, hydrogenated hard castor oil 1.0g, boric acid 1.0g, propylene glycol 1.0g, sodium chloride 0.5g, ethylparaben 0.025 g, add water for injection to the full amount to make 100g tinidazole ophthalmic gel.

[0026] Preparation method: with embodiment 1.

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PUM

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Abstract

The invention relates to tinidazole ophthalmic gel, and a preparation method and application thereof, and belongs to the technical field of medicines. Tinidazole serving as a medicinal active ingredient is prepared into ophthalmic gel for the first time, and the tinidazole ophthalmic gel is applied to the prevention and treatment of blepharitis ciliaris, hordeolum and conjunctivitis which are infected by worm mites, xerophthalmia caused by meibomian gland dysfunction and acanthamoeba protozoa in the process of wearing corneal contact lenses and anaerobic infection. The tinidazole ophthalmic gel consists of the tinidazole and a medicinally-acceptable carrier, and on the basis of the weight of the tinidazole ophthalmic gel, the using amount of the tinidazole is 0.1 to 3.0 grams in each 100 grams of tinidazole ophthalmic gel.

Description

technical field [0001] The invention relates to tinidazole, an active ingredient of medicine, which is made into an ophthalmic gel dosage form for the first time, and is applied to the prevention and treatment of ocular Demodex mite, Acanthamoeba and anaerobic bacteria infection. Background technique [0002] Intractable blepharitis, hordeolum, conjunctivitis, and dry eye caused by meibomian gland dysfunction (MGD) have recently been confirmed to be related to the infection of worms and mites (International Survey of Ophthalmology, 2007, 3: 149 ; Clinical Ophthalmology, 2010, 4:358). Mu Jian detected 90% of the demodectic mites in 91 patients with blepharitis (Journal of Clinical Ophthalmology, 2010, 4:358). Gao has a detection rate of 100% for Demodex mites on the eyelid (Invest ophthalmol vis sci, 2005, 46: 3089). Acanthamoeba keratitis is a severe blinding eye disease caused by Acanthamoeba infection. 75% of patients have a history of wearing contact lenses, which can c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/4164A61K47/44A61P27/02A61P33/02A61P33/10
Inventor 段亚东
Owner 段亚东
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