Sodium butyrate enteric sustained release preparation and preparation method thereof

A slow-release preparation, the technology of sodium butyrate, which is applied in the field of medicine, can solve the problems that the on-site operators of sodium butyrate are difficult to adapt to, the influence of the air environment is large, and the storage is inconvenient, so as to achieve improved bioavailability, good fluidity, good stability

Inactive Publication Date: 2012-07-18
HUBEI HAIYI BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because sodium butyrate has a strong cheese-like rancid smell, it is difficult for on-site operators to adapt to the production and use of sodium butyrate, and it has a great impact on the air environment in the production and use areas; sodium butyrate has strong hygroscopicity , easy to absorb moisture quickly, not easy to store

Method used

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  • Sodium butyrate enteric sustained release preparation and preparation method thereof
  • Sodium butyrate enteric sustained release preparation and preparation method thereof
  • Sodium butyrate enteric sustained release preparation and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0029] (1) see figure 1 , pump 400kg of purified water from the purified water metering tank 3 and add it to No. 1 reaction tank 1, start stirring, slowly add 175kg of sodium hydroxide, after fully dissolving, pump it into No. 2 reaction tank 2, and turn on the circulating water to control the temperature Around 50°C (48-50°C);

[0030] (2) Add 400kg of n-butyric acid to the 500L high-level metering tank 4, and then drop it into the No. 2 reaction tank 2 at a uniform speed. The temperature of the butyric acid solution is 48-50°C, and the reaction is continued for 1 hour after the dropwise addition, the reaction temperature is 50-55°C, and the pH is controlled between 7.0 and 7.5 to obtain a sodium butyrate reaction solution;

[0031] (3) Add 25 kg of ethyl cellulose, 93 kg of polyacrylic acid resin (purchased from Anhui Shanhe Pharmaceutical Excipients Co., Ltd.), 2 kg of propylene glycol, and glycerin monostearate to the above-mentioned sodium butyrate reaction solution (con...

Embodiment 2

[0035] (1) Pump 400kg of purified water from the purified water metering tank 3 and add it to No. 1 reaction tank 1, start stirring, slowly add 175kg of sodium hydroxide, after fully dissolving, pump it into No. 2 reaction tank 2, and turn on the circulating water Control the temperature at around 50°C;

[0036] (2) Add 400kg of n-butyric acid to the 500L high-level metering tank 4, and drop it into the No. 2 reaction tank 2 at a uniform speed. The temperature of the solution during the acid is controlled at 50-55°C; the dropwise addition is completed and the reaction is continued for 1 hour, the pH is controlled between 7.0 and 7.5, and the reaction temperature is 65-70°C to obtain a sodium butyrate reaction solution;

[0037] (3) Add 5kg of ethyl cellulose, 50kg of polyacrylic resin, 3kg of polypropylene glycol, 10kg of glyceryl monostearate, 432kg of beta cyclodextrin to the above reaction solution (containing about 500kg of sodium butyrate), and shear emulsify 10- 20 minu...

Embodiment 3

[0041] (1) Pump 400kg of purified water from the purified water metering tank 3 and add it to No. 1 reaction tank 1, start stirring, slowly add 175kg of sodium hydroxide, after fully dissolving, pump it into No. 2 reaction tank, and turn on the circulating water control The temperature is around 50°C;

[0042] (2) Add 400kg of n-butyric acid to the 500L high-level metering tank, drop it into the reaction tank at a constant speed, use circulating water to cool down and control the temperature at a maximum of 85°C, and finish the dropwise addition in 2 hours. The solution when adding n-butyric acid dropwise The temperature is 48-55°C; after the dropwise addition, the reaction is continued for 1.2 hours, the reaction temperature is 50-55°C, and the pH is controlled between 7.0 and 7.5 to obtain a sodium butyrate reaction solution;

[0043] (3) Add 5kg of ethyl cellulose, 50kg of polyacrylic resin, 5kg of propylene glycol, 20kg of glyceryl monostearate, 253kg of β-cyclodextrin to ...

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Abstract

The invention discloses a sodium butyrate enteric sustained release preparation and a preparation method thereof. The method comprises the following steps of: synthesizing sodium butyrate by a synthetic process, performing clathration on a synthesized sodium butyrate liquid in the liquid state, spraying and granulating to obtain the sodium butyrate enteric sustained release preparation. Accordingto the method, production links and production cost are reduced, the influence of the production process on environment is reduced, and the volatile smell and hygroscopicity of the product are reduced; and the prepared sodium butyrate enteric sustained release preparation is white spherical particles, and the particle size is 200 to 500 micrometers. The sodium butyrate enteric sustained release preparation is high in stability and humidity resistance and can be released in intestinal tracts slowly, so that the bioavailability of the product is improved.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a sodium butyrate enteric-coated sustained-release preparation and a preparation method thereof. Background technique [0002] Sodium butyrate is an organic acid sodium salt of short-chain fatty acids. It has various functions such as improving animal production performance, regulating the community structure of intestinal flora, maintaining the normal shape of the intestinal tract, and enhancing the immune function of the body. [0003] As a green and pollution-free feed additive, sodium butyrate is widely added to livestock and poultry feed to improve the health level of livestock and poultry, improve feed conversion rate and economic benefits. However, because sodium butyrate has a strong cheese-like rancid smell, it is difficult for on-site operators to adapt to the production and use of sodium butyrate, and it has a great impact on the air environment in the production and use areas; s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/19A61P1/00A23K1/16
Inventor 逯佩凤周玉岩
Owner HUBEI HAIYI BIOLOGICAL TECH CO LTD
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