Preparation method of L-lysine

A technology for lysine and lysine hydrochloride, which is applied in the field of preparing L-lysine using ion exchange resins, can solve the problems of large amount of compound reagents, increased production costs, long process routes, etc., and achieve product yield High efficiency, short reaction cycle and low raw material price

Inactive Publication Date: 2012-07-18
宁波海硕生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the L-lysine preparation technology in the prior art is prepared by chemical synthesis. This method has a long proces

Method used

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  • Preparation method of L-lysine
  • Preparation method of L-lysine

Examples

Experimental program
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Effect test

Embodiment 1

[0025] (1) Add purified water (deionized water) to L-lysine hydrochloride, the weight ratio of L-lysine hydrochloride to purified water is 1:1, mix well and dissolve completely, and place it for use ;

[0026] (2) Column adsorption

[0027] Add the lysine obtained by step (1) into the ion exchange column equipped with cation exchange resin at a flow rate of 13 L / min until the resin cation exchange resin completely absorbs lysine, and the discharge of the column does not contain lysine , and then use purified water to wash through the resin in the exchange column until there is no Cl in the effluent of the column - (the pH of the effluent at this moment is 7);

[0028] (3) Elution

[0029] Then use 2mol / L NH 4 OH (ammonia water) elutes L-lysine, NH 4 OH flows through the ion-exchange column at a flow rate of 13L / min. When the pH value of the effluent of the ion-exchange column rises to 8.0, the effluent begins to react with ninhydrin, that is, L-lysine begins to flow out, ...

Embodiment 2

[0034] (1) Add purified water (deionized water) to L-lysine hydrochloride, the weight ratio of L-lysine hydrochloride to purified water is 0.5:1, mix well and dissolve completely, and place it for use ;

[0035] (2) Column adsorption

[0036] Add the solution obtained in step (1) into an ion exchange column equipped with a cation exchange resin at a flow rate of 12 L / min, until the resin cation exchange resin completely absorbs lysine, and the discharge of the column does not contain lysine , and then use purified water to wash through the resin in the exchange column until there is no Cl in the effluent of the column - (the pH of the effluent at this moment is 7);

[0037] (3) Elution

[0038] Then use 2mol / L NH 4 OH (ammonia water) elutes L-lysine, NH 4 OH flows through the ion-exchange column at a flow rate of 12L / min. When the pH value of the effluent of the ion-exchange column rises to 8.0, the effluent begins to react with ninhydrin, that is, L-lysine begins to flow...

Embodiment 3

[0043] (1) Add purified water (deionized water) to L-lysine hydrochloride, the weight ratio of L-lysine hydrochloride to purified water is 0.8:1, mix well and dissolve completely, and place it for use ;

[0044] (2) Column adsorption

[0045] Add the lysine obtained by step (1) into the ion exchange column equipped with cation exchange resin at a flow rate of 15 L / min until the resin cation exchange resin completely absorbs lysine, and the effluent of the column does not contain lysine , and then use purified water to wash through the resin in the exchange column until there is no Cl in the effluent of the column - (the pH of the effluent at this moment is 7);

[0046] (3) Elution

[0047] Then use 2mol / L NH 4 OH (ammonia water) elutes L-lysine, NH 4 OH flows through the ion-exchange column at a flow rate of 15L / min. When the pH value of the effluent of the ion-exchange column rises to 8.0, the effluent begins to react with ninhydrin, that is, L-lysine begins to flow out,...

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Abstract

The invention discloses a preparation method of L-lysine. The method comprises the following steps of: (1) adding water into L-lysine hydrochloride, mixing uniformly, and fully dissolving; (2) adding a dissolved solution obtained in the step (1) into an ion exchange column filled with cation exchange resin at the flow speed of 12-15 liters per minute, and washing with water till an effluent of the column is free from Cl<->; (3) making 1.8-2.2mol/L of NH4OH flow through the ion exchange column at the flow speed of 12-15 liters per minute, and collecting an effluent which undergoes a ninhydrin reaction, i.e., L-lysine starts flowing out when the pH value of the effluent of the ion exchange column is 8.0; and (4) concentrating a collected solution under the reduced pressure of 0.1-0.3MPa at the temperature of 60-65 DEG C for removing ammonia, decolorizing with active carbon, filtering, cooling and crystalizing to obtain L-lysine. The method has the advantages of simple process flow, no use of a large quantity of compounds or chemical reagents, low raw material price, low environmental pollution and low manufacturing cost.

Description

technical field [0001] The invention relates to the technical field of L-lysine preparation, in particular to a novel method for preparing L-lysine by utilizing an ion exchange resin. Background technique [0002] L-lysine is the first essential amino acid in the human body. It is an important carrier for the synthesis of nucleoprotein, hemoglobin and fatty acid metabolism - an important component of carnitine. It is also an important amino acid for promoting the regeneration of brain nerve cells. Lysine can increase pepsin And gastric acid secretion, so it can promote the appetite of the elderly and children. Lysine has a certain auxiliary effect on malnutrition, hepatitis B, bronchitis, etc. Together with iron compounds, lysine is effective in treating anemia. [0003] At present, the L-lysine preparation technology in the prior art adopts a chemical synthesis method. This method has a long process route and a large amount of compound reagents. Therefore, it causes relat...

Claims

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Application Information

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IPC IPC(8): C07C229/26C07C227/18C07C227/40
Inventor 竺东海王恩荣覃向阳覃建华
Owner 宁波海硕生物科技有限公司
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