Device and method for eliminating pathogens in blood

A pathogen and pathogen physics technology, applied in the field of medical devices, can solve problems such as large side effects, adverse reactions, and other substances brought into the patient's blood, and achieve the effects of convenient operation, reduced side effects, and simple device structure.

Inactive Publication Date: 2012-07-25
王天欣 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Various methods of blood purification have their own advantages, but there are also defects such as large side effects, which are easy to bring other substances into the patient's blood, and cause adverse reactions.

Method used

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  • Device and method for eliminating pathogens in blood
  • Device and method for eliminating pathogens in blood
  • Device and method for eliminating pathogens in blood

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: Device embodiment

[0030] A device for removing pathogens from the blood, such as figure 1 As shown: it includes an extracorporeal circulation pathway composed of blood outflow tube 1, plasma separator 2 and blood return tube 3 connected in sequence, and also includes a pathogen physical inactivation device 5 connected to the extracorporeal circulation pathway. The specific connection method is: in the blood plasma A pathogen physical inactivation device 5 is connected to the plasma outflow pipe 4 and the plasma return pipe 6 of the separator 2 .

[0031] The connection method can also be: a pathogen physical inactivation device 5 is connected between the plasma outflow pipe 4 and the blood return pipe 3 or a pathogen physical inactivation device 5 is connected between the plasma outflow pipe 4 and the human body.

[0032] The pathogen physical inactivation device 5 includes an ultraviolet or microwave radiation device and a container, and the ultravio...

Embodiment 2

[0035] Embodiment 2: application embodiment

[0036] Such as figure 2 Shown, suffer from the patient's blood of AIDS to flow out from radial artery, it is passed through the plasma separator of embodiment 1 through blood pump action, and blood flow is 200ml / minute, and the plasma that is separated flows through a flat to ultraviolet transparent container ( For example, a quartz glass container with an internal volume of 10x10x1cm), the container is irradiated by an ultraviolet lamp with a wavelength of 253nm, and the irradiance intensity on the container is 60μW / cm 2 , the time for plasma to flow through the container is 30 seconds, and the entire operation lasts for 2 hours. It is then combined with blood cells and flowed back into the patient. After the above-mentioned intensity of ultraviolet radiation, more than 95% of HIV in the plasma sample can be inactivated through virus culture test.

[0037] The device can also be attached with an HIV adsorption device or a vi...

Embodiment 3

[0038] Embodiment 3: application embodiment

[0039] Such as image 3 As shown, the patient's blood (such as the blood of a patient with hepatitis B) flows into a hollow fiber plasma separator made of multiple polysulfone membranes. The total area of ​​the membrane is 0.5 square meters, and the membrane pore size is 0.2-0.6 microns. Both ends of the container are connected with arterial and venous pipelines to allow blood to flow through the hollow fibers, and the hollow fibers are filled with solid-phase carrier pathogen adsorbents. The blood flow rate is 100ml / min, and there are hepatitis B virus affinity substances on the solid-phase carrier pathogen adsorbent, such as cross-linked dextran particles with a particle size of 0.5 mm that are covalently linked to anti-hepatitis B surface antigen antibodies. The plasma containing pathogens diffuses through the micropores on the membrane to the outside of the hollow fiber and contacts with the solid-phase carrier pathogen ads...

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PUM

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Abstract

The invention relates to the field of medical devices, and particularly provides a device for eliminating pathogens in blood. The device for eliminating the pathogens in the blood comprises an external circulation path consisting of a blood exhalant (1), a plasma separator (2) and a blood return pipe (3) which are sequentially connected, and further comprises a pathogen physical deactivation device (5) connected with the external circulation path. The invention further provides a method for eliminating the pathogens in the blood, comprising the following steps: after the blood flows out from a patient body, blood cells and plasma in the blood are separated by the plasma separator; and after the pathogens in the plasma are physically deactivated through the pathogen physical deactivation device, the plasma flows back to the external circulation path and then flows back to the patient body in combination with the blood cells. The method adopts physical means and can reduce side effects. The device is simple in structure, and can be connected with other blood purification devices for use.

Description

technical field [0001] The invention belongs to the field of medical equipment, and relates to a device and a method for treating pathogen infection. In particular, it relates to a device and method for treating infections by inactivating pathogens in the blood. Background technique [0002] The specific operation of blood purification can be found in many textbooks, literature and research reports. Blood purification includes hemodialysis, hemofiltration, hemoperfusion, and plasma exchange. Hemodialysis, referred to as hemodialysis, also known as artificial kidney or kidney dialysis in popular terms, is a kind of blood purification technology. It uses the principle of semi-permeable membrane to remove various harmful and redundant metabolic wastes and excess electrolytes in the fluid through diffusion, so as to purify the blood and absorb to correct the water electrolyte and acid-base balance. Hemofiltration is to make blood flow through a filter in the extracorporeal ci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/36
Inventor 王天欣陈以旺邹沙舟
Owner 王天欣
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