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Preparation method of prednisone

A technology for prednisone and prednisone, which is applied in the field of preparation of prednisone, can solve problems such as large waste of chromium, waste of acetic acid, and can not be applied repeatedly, and achieves the effects of improving yield, reducing recovery cost and simple method.

Inactive Publication Date: 2012-08-01
浙江凯迪药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many preparation methods of prednisone in the prior art, but in the reaction process of preparing prednisone, the waste of chromium is very large, which cannot be repeated mechanically, and there is also a large waste of acetic acid at the same time.

Method used

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  • Preparation method of prednisone
  • Preparation method of prednisone

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Embodiment Construction

[0029] The technical solution of the present invention will be further specifically described below through specific examples, but the present invention is not limited to these examples.

[0030] A kind of preparation method of improving prednisone of the present invention, it comprises the steps:

[0031]

[0032] a) Prednisone is prepared from the mold oxide (I) as a starting material, and the mold oxide is subjected to a Platinum oxidation reaction to obtain a Platinum compound (II);

[0033] Platts (II)

[0034] b) Platinum compound (II) is subjected to bromine reaction to obtain upper bromide (III);

[0035]

[0036] Bromide(III)

[0037] c) the bromide (III) is subjected to a debromination reaction to obtain a debromide (IV);

[0038]

[0039] Debromide (IV)

[0040] d) the debrominated compound (IV) reacts with iodine on the 21st position to obtain prednisone (IV);

[0041]

[0042] Iodide (XI)

[0043] k) d substance (XI) undergoes a 21-position sub...

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Abstract

The invention discloses a preparation method of prednisone. The method comprises the following steps of: (a) preparing prednisone by taking a mold oxide (I) as a starting raw material, and undergoing a Platts oxidation reaction on the mold oxide to obtain a Platts substance (II); (b) undergoing a bromine addition reaction on the Platts substance (II) to obtain a bromine-added substance (III); (c) undergoing a bromine removing reaction on the bromine-added substance (III) to obtain a bromine-removed substance (IV); (d) undergoing a 21-bit iodine addition reaction on the bromine-removed substance (IV) to obtain prednisone (IV); and (k) undergoing a 21-bit replacement reaction on the substance (XI) obtained in the step (d) to obtain a replacement substance (IV). The preparation method has the advantages that: 1, after chromium waste water is treated, chromium can be used repeatedly, and the recovering cost of acetic acid can be reduced simultaneously; 2, totally-enclosed treatment is performed, waste water is drained after being concentrated, and all chromium is recovered, so that chromium pollution is avoided basically, and the concentration of acetic acid in water is reduced greatly simultaneously; and 3, a method for treating chromium waste water is simple, chromium is qualified, and adverse effects on a reaction are avoided.

Description

technical field [0001] The invention relates to the technical field of medicine and chemical industry, in particular to an improved preparation method of prednisone. Background technique [0002] Prednisone has anti-inflammatory and anti-allergic effects, can inhibit the proliferation of connective tissue, reduce the permeability of capillary walls and cell membranes, reduce inflammatory exudation, and inhibit the formation and release of histamine and other toxic substances. This crystal can also promote the decomposition of protein into sugar and reduce the utilization of glucose. As a result, both blood sugar and liver glycogen increase, and diabetes can occur. At the same time, gastric juice secretion is increased and appetite is increased. When used in conjunction with a large number of antimicrobials in severe toxic infections, it can have good cooling, anti-drug, anti-inflammatory, anti-shock and symptom relief effects. Its water and sodium retention and potassium e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J5/00
Inventor 周秋火
Owner 浙江凯迪药业有限公司
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