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Cane sugar-containing and sugar-free Shenkun blood nourishing granules with longer period of validity

A granule and sucrose technology, applied in the field of Shenkun Yangxue Granules and its preparation, can solve problems such as hidden dangers in production safety, poor product stability, and bitter taste, and achieve the effects of improving production efficiency, reducing sugar content, and reducing dosage

Active Publication Date: 2014-04-30
西安仁仁药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are two main disadvantages in the existing granules: (1) the extraction process is simple, the impurity components are many, the color is dark, and the taste is bitter; (2) the product has poor stability, and the general validity period is only 1-1.5 years
But because all do not fundamentally overcome the defective of above-mentioned prior art in above-mentioned two patents
Moreover, in the extraction of active ingredients, general "water extraction" is generally used, resulting in low utilization of active ingredients in Chinese medicinal materials, which cannot reduce the amount of medicine used and save Chinese medicine resources.
[0008] Secondly, the problem to be considered is that the one-time "alcohol precipitation" process is generally used when removing sugar from the water extract, which cannot remove impurities such as sugar, so that the solid particles in the product are still highly hygroscopic, resulting in poor overall stability of the preparation , cannot be stored for a long time
In addition, high-concentration ethanol is generally used as a wetting agent in the preparation of granules, resulting in too high ethanol content in the production workshop, which brings certain hidden dangers to the safe production of the entire process; wet granulation is generally used, the process is complicated, and the production efficiency is low

Method used

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  • Cane sugar-containing and sugar-free Shenkun blood nourishing granules with longer period of validity
  • Cane sugar-containing and sugar-free Shenkun blood nourishing granules with longer period of validity
  • Cane sugar-containing and sugar-free Shenkun blood nourishing granules with longer period of validity

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0039] Preparation Example 1: Sugar-Free Granules

[0040] A Shenkun Yangxue granule, characterized in that, the raw materials of traditional Chinese medicine of the Shenkun Yangxue granule are:

[0041]

[0042] Its preparation method comprises the following steps:

[0043] Material selection: Weigh the raw materials of the above-mentioned Chinese medicinal materials, wash them with drinking water, and combine them with air drying and blast drying at 40-65°C to control the moisture content in the medicinal materials to 4-8%;

[0044] Superfine pulverization: simply pulverize the selected medicinal materials into coarse powder, place them in a vibrating mill for superfine pulverization or a jet pulverizer for superfine pulverization for 15 minutes, and obtain a mixed fine powder with a particle size of 15-75 microns;

[0045] Reflux extraction: Add 8 times the amount of water to decoct twice, 1 hour each time, combine the decoctions and filter, and concentrate the filtrate...

preparation Embodiment 2

[0050] Preparation Example 2: Sugar-Containing Granules

[0051] A Shenkun Yangxue granule, characterized in that, the raw materials of traditional Chinese medicine of the Shenkun Yangxue granule are:

[0052]

[0053] Its preparation method comprises the following steps:

[0054] Material selection: Weigh the raw materials of the above-mentioned Chinese medicinal materials, wash them with drinking water, and combine them with air drying and blast drying at 40-65°C to control the moisture content in the medicinal materials to 4-8%;

[0055] Superfine pulverization: simply pulverize the selected medicinal materials into coarse powder, place them in a vibrating mill for superfine pulverization or a jet pulverizer for superfine pulverization for 15 minutes, and obtain a mixed fine powder with a particle size of 15-75 microns;

[0056] Reflux extraction: Add 8 times the amount of water to decoct twice, 1 hour each time, combine the decoctions and filter, and concentrate the fi...

preparation Embodiment 3

[0062] According to the extraction process steps of Preparation Example 2, the final thick paste d was obtained after recovering ethanol. Then, the thick paste d is divided into 5 equal parts (every equal part is equivalent to 160 grams of the original drug), and 0.2 gram of vitamin C, L-cysteine, sodium sulfite, gallic acid and blank are added respectively, according to the method of preparation example 3 Prepared as sugar granules.

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Abstract

The invention relates to Shenkun blood nourishing granules which comprises cane sugar-containing and sugar-free Shenkun blood nourishing granules, and particularly relates to a Shenkun blood nourishing granule which has the advantages of good taste, less taking dose, non-hygroscopicity, and long-term stability. The Shenkun blood nourishing granule is prepared by adopting traditional Chinese medicines of astragalus, codonopsis pilosula, salvia miltiorrhiza, angelica, herba leonuri and herba patriniae as raw materials, and extracting active ingredients. The Shenkun blood nourishing granule has the efficacies of reinforcing qi and nourishing blood, and promoting blood circulation to remove blood stasis, and is especially applicable to postpartum lochiorrhea and lower abdomen pain caused by qi deficiency and blood stasis. Specifically, in the invention, the extraction rate of the active ingredients of Chinese herbal medicines is improved, impurities such as sugars in traditional Chinese medicine extract are well removed by adopting ethanol precipitation, the thick paste viscosity is reduced, and the use of high-concentration ethanol is avoided finally in the preparation process so as to eliminate the hidden danger for the safety production of the whole process, finally reduce the hygroscopicity of solid granules in the product, and improve the overall stability of the preparation to enable the preparation to be stored for a long time.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a Shenkun Yangxue granule and a preparation method thereof. Background technique [0002] Lochia, abdominal pain is a common postpartum women's disease. Women lose blood and consume qi during childbirth, qi deficiency is unable to promote blood circulation, resulting in poor blood flow, sluggishness and abdominal pain. Deficiency of qi and less blood, fatigue and spleen injury after childbirth, so that the rush and function are not solid, and the blood cannot be absorbed, resulting in continuous lochia. [0003] In my country, women's postpartum lochia and pain in the lower abdomen are mainly treated with traditional Chinese medicine and Western medicine. Although Western medicine can achieve immediate results when treating this disease, its toxic and side effects are relatively large, and it is easy to relapse, and it cannot fundamentally cure the disease. As a bi...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/16A61P15/00
Inventor 高渊思
Owner 西安仁仁药业有限公司
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