Material for induction of hard tissue regeneration

Abstract

The invention relates to a material for inducing the regeneration of a hard tissue, and the material is characterized by comprising platelet-rich plasma and a gelatin beta-TCP sponge and capable of promoting angiogenesis, osteogenesis, chondrogenesis and the like.

Description

technical field [0001] The present invention relates to a material for inducing regeneration of hard tissue (such as bone or cartilage, etc.), which comprises platelet-rich plasma and gelatin β-TCP sponge. Background technique [0002] Traditionally, autologous bone grafting has been performed for bone healing at fracture sites and reconstruction of bone defect sites such as after resection of benign osteomas by harvesting bone from one's own healthy site and transplanting the bone to a bone defect site. However, complications occur at a high rate of about 30% due to the invasion of the healthy site, such as infection and residual pain at the bone supply site, nerve damage near the bone supply site, etc. In the case of bone healing and large bone defects, a large amount of autogenous bone is necessary, and substandard autologous bone supply sites sometimes cause clinical problems. [0003] To avoid autologous bone grafting and to compensate for insufficient autologous bone ...

AI Technical Summary

Problems solved by technology

However, it lacks wide applicability because various problems have accumulated: specialized facilities such as clean rooms (cell processing centers) where cell culture can be Plastid cells have the risk of canceration, differentiation induction may not be perfect, etc.

[0007] However, PRP alone is insufficient to provide adequate osteogenesis in large bone defects, anatomically unfused bones, and spinal fusions used to join vertebrae together, with three-dimensional structures that promote differentiation and induce osteoblasts. Brackets are essential

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