Preparation of artificial bone bracket with controllable pore connectivity
A connectivity, artificial bone technology, applied in the direction of bone implants, etc., can solve the problem that artificial bone scaffolds can not meet the connectivity requirements well, achieve effective controllable pore connectivity, improve manufacturing efficiency, accurate post-processing, etc. The effect of processing time
Active Publication Date: 2014-07-02
西安博恩生物科技有限公司
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[0009] In order to overcome the shortcomings of the prior art artificial bone scaffolds that cannot meet the connectivity requirements well, thereby ensuring the delivery of nutrients and the excretion of cell metabolites, the present invention proposes a preparation of a bioceramic microsphere scaffold with controllable connectivity. method
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[0026] Specific implementation examples
[0027] The preparation method of the bioceramic microsphere artificial bone scaffold with controllable connectivity in this embodiment specifically includes the following steps:
[0028] Step 1. Use PFC3D particle flow software for modeling and simulation, and generate two kinds of small balls with different diameters. The large balls represent bioceramic small balls with a diameter of D=0.6mm; the small balls represent degradable small balls with a diameter of For d=0.3mm; in the present embodiment, the bioceramic bead is a hydroxyapatite microsphere, which is a degradable bead glucose material microsphere;
[0029] Step 2. Mix two kinds of small balls with different diameters evenly, and enter the virtual container under the action of gravity, and finally reach stability;
[0030] Step 3. Delete the large ball in the model obtained in step 2, leaving the small ball, and then judge whether the small balls are connected according to t...
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The invention discloses a preparation method of an artificial bone bracket based on porous bioceramic microspheres. The preparation method comprises the following steps of: establishing a CAD (Computer Aided Design) model according to individual characteristics of patients; introducing the model into a three-dimensional printer; uniformly mixing bioceramic microspheres and biological degradable microspheres in a certain proportion according to a discrete numerical value particle flow analysis software numerical value calculation result; and then sprinkling a biological adhesive to adhere mixed spheres through the three-dimensional printer to realize preparation of the artificial bone bracket. According to the method, an ideal model which can be conveniently and efficiently obtained by changing the percentage of the numbers of the microspheres in the mixed microspheres and the diameter of the microspheres based on the discrete particle numerical value calculation theory is established, and the material performance is predicted, so that effective controllability of pore conductivity of the artificial bone bracket is realized, and unnecessary waste is avoided. Meanwhile, the pureness of the bioceramic material is guaranteed by utilizing the biodegradable material, the probability for pollution of the bioceramic is reduced, and meanwhile, the post-treatment time can also be accurately controlled.
Description
[0001] Field: [0002] The invention relates to a method for preparing an artificial bone scaffold based on porous bioceramic microspheres. It involves using discrete numerical simulation and particle flow numerical simulation as calculation theories to obtain active bioceramic microsphere artificial bone scaffolds with certain pore connectivity by controlling the number and diameter of vanishing spheres. Background technique: [0003] As an important carrier for bone tissue culture in vitro, artificial bone scaffolds provide living space for the adhesion and proliferation of seed cells, provide channels for cells to obtain nutrition and metabolism, and provide the necessary mechanical support for tissues during the osteogenesis stage. Therefore, the microscopic pore structure, mechanical properties, bioactivity and degradation rate of the scaffold all have an important impact on the construction of bone tissue. In particular, the microscopic pore structure of the scaffold pl...
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IPC IPC(8): A61F2/28
Inventor 汪焰恩魏庆华李鹏林秦琰磊杨明明叶东东龙水军潘飞龙郭叶魏生民
Owner 西安博恩生物科技有限公司