Preparation method for antibacterial composite material

Abstract

The invention discloses a preparation method for an antibacterial composite material. The preparation process of the preparation method comprises the following steps: (1) dissolving or dispersing nano silk fibroin powder, polyurethane and silver salt in the same organic solvent to obtain a silk fibroin solution, a polyurethane solution and a silver salt solution; (2) by stirring at 55-60 DEG C in a water bath, adding the silk fibroin solution to the polyurethane solution for mixing and sufficient reacting, and then adding the silver salt solution to a mixed system of the silk fibroin solution and the polyurethane solution; after the obtained reaction solution becomes brown yellow, separating out a reaction product by using mass water; stirring and washing the reaction product by using a large quantity of water to remove residual organic solvents until the water is clear without oily matters; and drying to obtain the antibacterial composite material. The composite antibacterial material prepared by the method has the advantages of controllable parameter, simple process, benefit to large-scale production, low cost, remarkable antibacterial effect and good biocompatibility and formability.

Description

technical field [0001] The invention relates to a composite material, in particular to a silver-loaded nano silk fibroin / polyurethane antibacterial composite material and a preparation method thereof. The antibacterial composite material prepared by the method is especially suitable for the field of biomedical materials requiring high biocompatibility, and belongs to the technical field of high-tech materials. [0002] Background technique [0003] The reproduction and transmission of microorganisms such as harmful bacteria, fungi and viruses is one of the reasons for the occurrence and infection of human diseases. Such as the widespread nosocomial infection problem in the hospital at present, make the patient suffer from great misery. Most medical materials used clinically, such as polyurethane and natural rubber latex, do not have antibacterial properties, and microorganisms are easy to attach and grow on their surfaces, which has become the chief culprit of nosocomial i...

AI Technical Summary

Problems solved by technology

However, like other biomaterials, there are three main problems with polyurethane: blood clotting, calcification and infection

For example, Luo Jianbin and others have synthesized polyurethanes containing diquaternary ammonium salts in the hard segment, which improves the antibacterial performance of polyurethane materials, but the antibacterial activity of diquaternary ammonium salts on the polymer chain segment decreases, and the effect on Gram-negative bacteria is very poor.

Polyurethane / nano-silver has excellent antibacterial properties, but the problem of agglomeration of nano-silver has not been solved, and there may be defects such as cytotoxicity, which limits its development and application

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