Preparation method for antibacterial composite material

A composite material and polyurethane technology, applied in the silver-loaded nano-silk fibroin/polyurethane antibacterial composite material and its preparation, in the field of composite materials, can solve the problem of nano-silver agglomeration, which has not been solved, the antibacterial activity of biquaternary ammonium salt is decreased, and the The problems of poor Lan's negative bacteria effect, etc., achieve the effects of good biocompatibility and formability, low cost of raw materials, and obvious antibacterial effect.

Active Publication Date: 2012-10-03
重庆惠森驰恒医疗器械有限公司
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Problems solved by technology

However, like other biomaterials, there are three main problems with polyurethane: blood clotting, calcification and infection
For example, Luo Jianbin and others have synthesized polyurethanes containing diquaternary ammonium salts in the hard segment, which improves the antibacterial performance of polyurethane materials, but the antibacterial activi

Method used

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  • Preparation method for antibacterial composite material
  • Preparation method for antibacterial composite material
  • Preparation method for antibacterial composite material

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Embodiment Construction

[0033] Nano-silver has a large specific surface area, and there are a large number of atoms or particle vacancies on the particle surface, which shows a large surface activity. There are many dangling bonds on the surface. bond, so the present invention utilizes a small amount of nano-scale silk fibroin to combine with polyurethane, and then introduces Ag with good antibacterial activity. + , using the solvent and the reducing ability of silk fibroin itself to prepare well-dispersed nano-silver, so that the composite material can better combine the advantages of the three, learn from each other, and prepare a stable combination, good antibacterial performance, and good biocompatibility Composite materials with good formability.

[0034] The preparation technology of silver-loaded nano silk fibroin / polyurethane composite material of the present invention is as follows:

[0035] (1) Dissolve or disperse nano-silk fibroin powder, polyurethane and silver salt in the same organic ...

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Abstract

The invention discloses a preparation method for an antibacterial composite material. The preparation process of the preparation method comprises the following steps: (1) dissolving or dispersing nano silk fibroin powder, polyurethane and silver salt in the same organic solvent to obtain a silk fibroin solution, a polyurethane solution and a silver salt solution; (2) by stirring at 55-60 DEG C in a water bath, adding the silk fibroin solution to the polyurethane solution for mixing and sufficient reacting, and then adding the silver salt solution to a mixed system of the silk fibroin solution and the polyurethane solution; after the obtained reaction solution becomes brown yellow, separating out a reaction product by using mass water; stirring and washing the reaction product by using a large quantity of water to remove residual organic solvents until the water is clear without oily matters; and drying to obtain the antibacterial composite material. The composite antibacterial material prepared by the method has the advantages of controllable parameter, simple process, benefit to large-scale production, low cost, remarkable antibacterial effect and good biocompatibility and formability.

Description

technical field [0001] The invention relates to a composite material, in particular to a silver-loaded nano silk fibroin / polyurethane antibacterial composite material and a preparation method thereof. The antibacterial composite material prepared by the method is especially suitable for the field of biomedical materials requiring high biocompatibility, and belongs to the technical field of high-tech materials. [0002] Background technique [0003] The reproduction and transmission of microorganisms such as harmful bacteria, fungi and viruses is one of the reasons for the occurrence and infection of human diseases. Such as the widespread nosocomial infection problem in the hospital at present, make the patient suffer from great misery. Most medical materials used clinically, such as polyurethane and natural rubber latex, do not have antibacterial properties, and microorganisms are easy to attach and grow on their surfaces, which has become the chief culprit of nosocomial i...

Claims

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Application Information

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IPC IPC(8): C08L75/06C08L75/08C08L89/00C08K3/28C08K5/3462C08J5/18C12P21/06
Inventor 陈忠敏罗琴刘琼胡辰廖大刚邱荣蓉
Owner 重庆惠森驰恒医疗器械有限公司
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