Trollius chinensis dreg fermented product with antifungal effect and process for preparing trollius chinensis dreg fermented product

A preparation process, the technology of nasturtium, is applied in the direction of antifungal agents, local antibacterial agents, medical preparations containing active ingredients, etc., which can solve the problems of polluting the environment, consuming large costs, etc., and achieve high benefits, short production cycles, and good quality. The effect of the treatment effect

Active Publication Date: 2012-10-17
NORTH CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to incomplete statistics, there are millions of tons of dregs produced by the use of Trollius pharmaceuticals in the country every year, and most of them are discarded, which not only pollutes the environment, but also consumes a lot of money for the disposal of dregs.

Method used

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  • Trollius chinensis dreg fermented product with antifungal effect and process for preparing trollius chinensis dreg fermented product
  • Trollius chinensis dreg fermented product with antifungal effect and process for preparing trollius chinensis dreg fermented product
  • Trollius chinensis dreg fermented product with antifungal effect and process for preparing trollius chinensis dreg fermented product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] ① Yeast activation and proliferation culture: Enrichment liquid medium: Yeast = 100ml: 5g, cultivated in a constant temperature incubator at 35°C for 7 hours.

[0028] ② Ratio of activated yeast to Trollius dregs: Activated yeast liquid: Trollius dregs = 100ml: 40g.

[0029] ③The fermentation conditions are: temperature 30°C, time 96 hours.

[0030] ④ Extraction method of fermented product: add absolute ethanol to the fermented product to make the ethanol concentration reach 60%, extract at 70°C for 2 hours, and centrifuge at 1500 rpm for 25 minutes. Ethanol is recovered from the supernatant, and the remaining liquid after recovering the ethanol is formed into a paste in a water bath at 70°C, and dried in an oven at 80°C to obtain the fermented extract of Trollus chinensis dregs.

Embodiment 2

[0032] ① Yeast activation and proliferation culture: Enrichment liquid medium: Yeast = 100ml: 8g, cultivated in a constant temperature incubator at 36°C for 6 hours.

[0033] ② Ratio of activated yeast to Trollius dregs: Activated yeast liquid: Trollius dregs = 100ml: 50g.

[0034] ③ The fermentation conditions are: temperature 34°C, time 84 hours.

[0035] ④Extraction method of fermented product: Add absolute ethanol to the fermented product to make the ethanol concentration reach 70%, extract at 70°C for 4 hours, and extract the extract at 2000 rpm / centrifuge for 20 minutes. Ethanol is recovered from the supernatant, and the remaining liquid after recovering the ethanol is formed into a paste in a water bath at 70°C, and dried in an oven at 80°C to obtain a fermented extract of Trollus chinensis dregs.

Embodiment 3

[0037] ① Yeast activation and proliferation culture: YPD liquid medium: yeast = 100ml: 10g, cultured in a constant temperature incubator at 37°C for 5 hours.

[0038] ② Ratio of activated yeast to Trollius dregs: Activated yeast liquid: Trollius dregs = 100ml: 60g.

[0039] ③ The fermentation conditions are: temperature 37°C, time 72 hours.

[0040]④Extraction method of fermented product: Add absolute ethanol to the fermented product to make the ethanol concentration reach 80%, extract at 70°C for 3 hours, and centrifuge the extract at 2500 rpm for 15 minutes. Ethanol is recovered from the supernatant, and the remaining liquid after recovering the ethanol is formed into a paste in a water bath at 70°C, and dried in an oven at 80°C to obtain the fermented extract of Trollus chinensis dregs.

[0041] Embodiments 1, 2, and 3 were ground into powders, respectively made into capsules, tablets, and granules for oral administration in animals, and made into creams, ointments, and lo...

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Abstract

The invention relates to a trollius chinensis dreg fermented product with an antifungal effect and a process for preparing the trollius chinensis dreg fermented product, and belongs to the technical field of treating fungal infection diseases. The technical scheme is as follows: the dried trollius chinensis dreg is ground into powder to be used as a raw material, the Anqi yeast is taken as a fermenting strain, the nutrition ingredients of peptone and glucose which are necessary to the yeast growth are added at the same time, and the trollius chinensis dreg fermented product is extracted; and the trollius chinensis dreg fermented product is an ethanol extract of a fermented product, and each gram of the dried trollius chinensis dreg fermented product contains 12.5-25 gram of dregs equivalently. The experimental result shows that the trollius chinensis dreg fermented product has a very good curative effect on an experimental animal infected with fungus, and no toxic and side effects are found out; and the trollius chinensis dreg fermented product has a good inhibition or sterilization effect on pathogenic or drug-resistant fungi strains which are clinically separated, and has the antifungal concentration which is consistent with that the clinically common antifungal drugs-fluconazole and jie'eryin. The trollius chinensis dreg fermented product provides a new choice for clinical or livestock antifungal drugs, and has the characteristics of low cost, convenience in application, high benefit and the like.

Description

technical field [0001] The invention relates to an antifungal fermented product of nasturtium medicinal dregs and a preparation process thereof, belonging to the technical field of treating fungal infection diseases. Background technique [0002] Chinese medicine has a long history in my country, and Chinese medicine industry is one of the traditional industries in our country. While producing a large amount of Chinese patent medicines, traditional Chinese medicine enterprises will produce a considerable amount of medicinal residues, which are generally wet materials, easily corrupted, and have a bad smell. The forms of early treatment of traditional Chinese medicine residue mainly include landfill, incineration, and stacking in fixed areas. These treatment methods not only consume a lot of money, but also cause resource waste and serious pollution. How to deal with traditional Chinese medicine dregs has become an urgent problem to be solved. Therefore, the use of biotechn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61P31/10A61P31/02
Inventor 韩淑英王志路王建行胡雷储金秀白静张博男韩婷安春娜勾向博王树华张潇
Owner NORTH CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
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