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Preparation method of high-purity spherical full-hole polystyrene-based particles

A polystyrene-based and styrene-based technology, which is applied in the field of preparation of polystyrene-based micro-spheres, can solve problems such as restricted use, and achieve the effects of size controllability, improved stability and good mechanical strength.

Active Publication Date: 2014-05-07
微纯生物科技(广州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the particles prepared by this method are nearly spherical, and the pore size is only 80?, which limits its wider use.

Method used

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  • Preparation method of high-purity spherical full-hole polystyrene-based particles

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preparation example Construction

[0023] In view of the many defects of the preparation method disclosed in the background technology, the present invention innovatively proposes a method for preparing high-purity spherical full-porous polystyrene-based particles. The particles prepared by this method are terpolymer particles of styrene, divinylbenzene and N-vinylpyrrolidone. The product has the best hydrophilic-lipophilic balance, making the particles resistant to various organic solvents and aqueous phases The system has good wettability and is suitable for pretreatment of various types of samples.

[0024] From the overview of the preparation method of the present invention, it includes preparing an aqueous solution (water phase) containing a surfactant, preparing an organic mixed solution of styrene, divinylbenzene and N-vinylpyrrolidone (oil phase), and making the water phase oil The phases are mixed to obtain an O / W emulsion. Emulsion polymerization initiated by free radicals, filtered through filter pa...

Embodiment 1

[0031] Embodiment 1—— At room temperature (20~25°C), add 500mL of deionized water, 6.3g of Triton X-100 and 0.7g of sodium dodecylsulfonate into a 1L three-necked flask, and stir for 30 minutes to form a uniform aqueous phase solution.

[0032] At room temperature, add 80 g of styrene, 10 g of divinylbenzene and 10 g of N-vinylpyrrolidone into a 500 mL Erlenmeyer flask, and stir evenly to form a colorless transparent solution. Add 0.2 g of azobisisobutyronitrile (AIBN), stir and dissolve at room temperature. Add the dissolved organic phase (oil phase) to the above water phase, and form a stable emulsion under mechanical stirring (domestic S312-90 mechanical stirrer, 100 rpm, 10 cm diameter stirring plate).

[0033]Raise the temperature to 70°C to initiate polymerization. After 10 hours of reaction, cool down to 30°C, filter with a 20-micron nylon filter cloth, wash the filter cake once with 0.5 times the original volume of deionized water, and then use 0.5 times the origina...

Embodiment 2

[0034] Embodiment 2—— At room temperature (20-25°C), add 500mL of deionized water, 6.5g of Tween 20 and 0.5g of sodium dodecylbenzenesulfonate into a 1L three-necked flask, and stir for 30 minutes to form a uniform aqueous phase solution.

[0035] At room temperature, add 80 g of styrene, 10 g of divinylbenzene and 10 g of N-vinylpyrrolidone into a 500 mL Erlenmeyer flask, and stir evenly to form a colorless transparent solution. Add 0.2 g of azobisisobutyronitrile (AIBN), stir and dissolve at room temperature. Add the dissolved organic phase (oil phase) to the above water phase, and form a stable emulsion under mechanical stirring (domestic S312-90 mechanical stirrer, 300 rpm, 10 cm diameter stirring plate).

[0036] Raise the temperature to 70°C to initiate polymerization. After 10 hours of reaction, cool down to 30°C, filter with a 20-micron nylon filter cloth, wash the filter cake once with 0.5 times the original volume of deionized water, and then use 0.5 times the orig...

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Abstract

The invention discloses a preparation method of high-purity spherical full-hole polystyrene-based particles, wherein the particles are terpolymer particles of styrene, divinyl benzene and N-vinyl pyrroiidone. The preparation method is characterized by mainly comprising the following steps: preparing an aqueous solution containing a surfactant; preparing organic mixed oil of styrene, divinyl benzene and N-vinyl pyrroiidone; mixing the aqueous solution and the organic mixed oil to prepare O / W emulsion; initiating the O / W emulsion to polymerize through free radical; and filtering through filter paper, cleaning and drying to prepare the spherical full-hole polystyrene-based particles. By applying the technical scheme, the spherical appearance and pore diameter of the particles can be effectively improved, and the defect of a conventional biopolymer is overcome; the method has a simple process, excellent repeatability and low cost, and is easy for scale production; the prepared material has the advantages of high purity, good mechanical strength, narrow particle size distribution, controllable size, narrow and controllable pore diameter distribution, and is suitable to be used as a medium for high-grade solid-phase extraction.

Description

technical field [0001] The invention relates to the preparation technology of polystyrene-based micron spheres, and in particular provides a preparation method of high-purity spherical full-hole polystyrene-based micron sphere particles. Background technique [0002] Solid-phase extraction technology is a sample pretreatment technology that uses solid substances as extraction agents and uses efficient and highly selective stationary phases for extraction. As an emerging processing technology for sample enrichment and purification, compared with traditional liquid-liquid extraction, SPE has fast extraction speed and high efficiency. More importantly, avoiding the use of a large amount of organic solvents is a low-cost, green and environmentally friendly sample processing technology. [0003] SPE is a sorbent extraction technique such as figure 1 As shown, the sample passes through the disposable extraction column 1 filled with adsorbent 3 (including polyethylene porous frit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F212/08C08F212/36C08F226/10C08F2/30C08F2/26C08J9/00
Inventor 黄曦
Owner 微纯生物科技(广州)有限公司
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