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Apparatus and methods for characterization of lung tissue by Raman spectroscopy

A Raman spectroscopy and characterization technique, applied in Raman scattering, using spectral diagnostics, instruments for radiodiagnosis, etc., can solve problems such as low specificity of AFB

Inactive Publication Date: 2012-10-17
曾海山
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, the main reason for the high number of false positives is the inherently low specificity of AFB

Method used

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  • Apparatus and methods for characterization of lung tissue by Raman spectroscopy
  • Apparatus and methods for characterization of lung tissue by Raman spectroscopy
  • Apparatus and methods for characterization of lung tissue by Raman spectroscopy

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example 1

[0097] use figure 2 A near-infrared Raman system of the type exemplified in , to acquire real-time in vivo lung spectra of lesions in lung tissue. Lung tissue was obtained from 26 people selected from a group of 46 people who underwent bronchoscopy. Bronchologists use combined WLB and AFB to identify lesions for biopsy. Of the 46 participants, 26 were found to have lesions recommended by a bronchologist for biopsy. Raman spectra from these lesions were obtained using the equipment described herein. 129 Raman spectra were measured. Obtain clear in vivo Raman spectra in one second exposure.

[0098] Biopsies were taken at the same location and triaged by a pathologist. According to World Health Organization guidelines (see e.g. Travis WD et al., Histologic and graphical text slides for the histological typing of lung and pleural tumors.), using eight classifications. The eight categories are: normal epithelium, hyperplasia (including goblet cell hyperplasia and basal / res...

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Abstract

Near-infrared Raman spectroscopy can be applied to identify preneoplastic lesions of the bronchial tree. Real-time in vivo Raman spectra of lung tissues may be obtained with a fiber optic catheter passed down the instrument channel of a bronchoscope. Using prototype apparatus, preneoplastic lesions were detected with sensitivity and specificity of 96 % and 91 % respectively. The use of Raman spectroscopy apparatus and methods in conjunction with other bronchoscopy imaging modalities can substantially reduce the number of false positive results.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Patent Application No. 61 / 297486, filed January 22, 2010, entitled ENDOSCOPIC LASER RAMAN SPECTROSCOPY FOR IMPROVING LUNG CANCER DETECTION, and filed October 7, 2010, entitled LASER RAMAN SPECTROSCOPY REDUCES FALSE POSITIVE BIOPSIES Priority to US Patent Application No. 61 / 390723 of OF AUTOFLUORESCENCE BRONCHOSCOPY. For the United States, this application claims the benefit of U.S. Patent Application No. 61 / 297486, filed January 22, 2010, and U.S. Patent Application No. 61 / 390723, filed October 7, 2010, under U.S.C. §119, Both documents are incorporated herein by reference. technical field [0003] The present invention relates to the characterization of tissues. The invention may be applied, for example, to provide methods and devices for lung tissue assessment for cancer. One example embodiment provides an endoscopic device that may be used by a physician to assess the lik...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B1/267A61B6/00G01N21/65
CPCA61B5/0075A61B5/0071G01N21/65A61B5/0084
Inventor 曾海山M·绍特S·拉姆A·麦克威廉姆斯
Owner 曾海山
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