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Detection method of cassiabarktree twig tuckahoe capsules

A technique of Guizhi Fuling and a detection method, which is applied in the direction of measuring device, color/spectral characteristic measurement, instrument, etc., can solve the problems of unfavorable Guizhi Fuling capsule quality control, cumbersome pretreatment, long detection time, etc., so as to shorten the detection time. , Good reproducibility and good precision

Inactive Publication Date: 2012-10-31
JIANGSU KANION PHARMA CO LTD
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Problems solved by technology

Although the detection of active ingredients in Guizhi Fuling Capsules by high performance liquid chromatography has the advantages of high separation efficiency and high sensitivity, the pretreatment is cumbersome and the detection time is long, which is not conducive to the quality of Guizhi Fuling Capsules in mass production. control

Method used

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  • Detection method of cassiabarktree twig tuckahoe capsules
  • Detection method of cassiabarktree twig tuckahoe capsules
  • Detection method of cassiabarktree twig tuckahoe capsules

Examples

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Embodiment 1

[0136] Taking 59 finished products of Guizhi Fuling Capsules provided by the Quality Standard Research Center of Jiangsu Kangyuan Pharmaceutical Co., Ltd. as samples, they were randomly divided into 53 calibration sets and 6 validation sets, which were recorded as calibration samples 1-53 and validation samples 1 ~6; The Luminar5030 portable AOTF near-infrared spectrometer produced by the American BRIMROSE company is used for detection, and the detector is InGaAs; the spectrum acquisition and processing software is Snap! ; Quantitative analysis software is TheUnscrambler; detection conditions are as follows: wavelength range 1100nm ~ 2300nm; wavelength increment 2.0nm; ratio mode Ratio Mode.

[0137] 1.1 Determination of Guizhi Fuling Capsule Samples by HPLC

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Abstract

The invention provides a detection method of cassiabarktree twig tuckahoe capsules. The method comprises the steps that: solid powder in the cassiabarktree twig tuckahoe capsules is adopted as a sample requiring detection; the sample requiring detection is detected by using a near-infrared spectrometer, so that near infra-red spectrum data of the sample is obtained; according to correction models of gallic acid, peoniflorin, benzoic acid, benzoylpaeoniflorin, cinnamaldehyde, paeonol, and amygdalin, and the obtained near infra-red spectrum data, the contents of gallic acid, peoniflorin, benzoic acid, benzoylpaeoniflorin, cinnamaldehyde, paeonol, and amygdalin in the sample are obtained. According to the invention, the sample requiring detection does not need complicated pretreatments such as separation and extraction. The detection time is shortened, the detection efficiency is improved, and work load is reduced. Also, when the detection method provided by the invention is adopted in detections upon large batches of samples, the result is accurate, and the repeatability is good.

Description

technical field [0001] The invention belongs to the technical field of detection of traditional Chinese medicines, and in particular relates to a detection method of Guizhi Fuling capsules. Background technique [0002] Guizhi Fuling Capsule is a modern dosage form of the ancient prescription Guizhi Fuling Pill. It is derived from Zhang Zhongjing's "Synopsis of the Golden Chamber" in the Han Dynasty. , the effect of eliminating symptoms and accumulation, can be used to treat gynecological diseases, such as dysmenorrhea, amenorrhea, lochia, pelvic inflammatory disease, pelvic mass, uterine fibroids, adenomyosis, ovarian cysts, breast hyperplasia, infertility, drugs Post-abortion vaginal bleeding, endometriosis and many other diseases. [0003] Guizhi Fuling capsules are generally prepared according to the following steps: extract active ingredients of Chinese medicinal materials such as cinnamon twigs, poria cocos, paeonol, peony, peach kernel, etc., and prepare capsules thr...

Claims

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Application Information

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IPC IPC(8): G01N21/25G01N30/02
Inventor 萧伟王振中朱克近毕宇安李家春宫凯敏章晨峰王正宽郑伟然
Owner JIANGSU KANION PHARMA CO LTD
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