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Application of extract of Chimonanthus Salicifolius. S.Y.H. in preparation of gastric cancer treating medicine

A technology of extracts and wintersweet, applied in the field of preparation of Chinese patent medicines, to achieve the effect of increasing therapeutic drugs, easily obtaining materials, and reducing treatment costs

Active Publication Date: 2014-01-29
浙江华润三九众益制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no application of willow wax plum extract for gastric cancer medicine at present.

Method used

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  • Application of extract of Chimonanthus Salicifolius. S.Y.H. in preparation of gastric cancer treating medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Take the dry leaves of the willow-leaved wintersweet in the prescription, add 6 times the amount of water, and extract by steam distillation for 4 hours. Collect the volatile oil and aromatic water, add β-CD to 60°C distilled water and aromatic water to make a saturated solution, and heat it at 600r / min conditions, according to β-CD and volatile

[0012] Oil 8: l (g:ml) ratio, slowly dropwise add the volatile oil of Chimerus osmanthus dissolved in an appropriate amount of ethanol in advance, stir for 2 hours, let it stand overnight, filter to obtain the clathrate of waxy wax volatile oil, and place it in freeze-drying In the machine, freeze-dry for 24 hours. Take it out, crush it, pass through an 80-mesh sieve, and put it in capsules to get the finished product.

[0013] Its preferred application dosage is that the content of wax plum oil is 0.001-0.25ml / kg.

[0014] In order to confirm the curative effect of wax plum oil of the present invention in the treatment of ga...

Embodiment 2

[0036] The most preferred application dose of the clathrate medicine of the volatile oil of the wax plum obtained in Example 1 is that the oil content of the wax plum is 0.02-0.06ml / kg, and it is used as a medicinal material for preparing a medicine for treating gastric cancer.

Embodiment 3

[0038] According to Example 1, 1-10ml of the volatile oil of Wintersweet willow, 1-10g of lactose, 10-100g of polyethylene glycol 4000 or polyethylene glycol 60000, 0.01-1g of polysorbate, heated and mixed evenly, kept at 40°C-50 ℃, drop into the liquid paraffin condensate to obtain the dripping pills used for the treatment of gastric cancer.

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Abstract

The invention relates to an application of an extract of Chimonanthus Salicifolius. S.Y.H. in preparation of a gastric cancer treating medicine. The application of Chimonanthus Salicifolius. S.Y.H. oil in preparation of gastric cancer treating medicine is characterized in that the extract of Chimonanthus Salicifolius. S.Y.H. is used for preparing a medicine for inhibiting proliferation of gastric cancer SGC-7901 cells and inducing cell apoptosis. Due to the fact that the Chimonanthus Salicifolius. S.Y.H. is a plant widely growing in the South, with the adoption of the extract as a digestive tract tumor medicine, the material is not only easy to obtain, but also can be effectively used as the gastric cancer treating medicine, the treating cost is reduced, the treatment plan is simplified and the medicine is safe and reliable.

Description

technical field [0001] The invention relates to the field of preparation of Chinese patent medicines, in particular to the application of a willow-leaved wintersweet extract as a medicine for treating gastric cancer. Background technique [0002] Malignant tumors are one of the major diseases that endanger human health. At present, the number of deaths due to cancer is still more than 6 million in the world every year, especially in developing countries, the morbidity and mortality of cancer are still rising. The number of deaths due to cancer is about 1.3 million in my country every year, and 5 in China every year One of those deaths is from cancer. Malignant tumors of the digestive tract are one of the most common malignant tumors in clinical practice. With the continuous progress of traditional treatment methods such as surgery, chemotherapy, and radiotherapy, a large number of investigations have been carried out on the treatment options and prognosis of gastric cancer, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P35/00A61K127/00
Inventor 刘忠达袁宙新李继承
Owner 浙江华润三九众益制药有限公司
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