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Medicine osmotic pump preparation

An osmotic pump and drug technology, applied in the directions of osmotic delivery, drug delivery, pill delivery, etc., to achieve the effect of controllable drug release rate and complete drug release

Active Publication Date: 2013-01-16
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

U.S. patents (US4203439, US4331728) have reported using substances that can generate air bubbles as the push chamber inside the tablet core to release the drug at a constant rate and completely. However, the structure of this osmotic pump is driven by the pressure formed by the air bubbles and does not involve Bubble-like fine structure formed by liquid vesicles

Method used

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  • Medicine osmotic pump preparation
  • Medicine osmotic pump preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] (1) Tablet core prescription:

[0060]

[0061] (2) Prescription of semi-permeable membrane coating solution:

[0062]

[0063] (3) Preparation process: Weigh each component according to the prescription amount, mix them evenly, and compress the tablet; coat the tablet core with acetone solution of cellulose acetate-PEG4000 until the weight of the tablet core increases by 4%; A small hole with a diameter of 0.8 mm was punched on one side of the sheet.

[0064] (4) Measuring method: Paddle method is adopted, 900mL degassed distilled water is used as release medium, and the rotating speed is 75 revolutions per minute. The release degree at different time points was measured, and the osmotic pump tablets were taken out at different dissolution time points, sealed in a desiccator filled with a desiccant (silica gel) at room temperature, and placed for 48 hours. Acquire two-dimensional images with a 180-degree viewing angle to complete SR-μCT three-dimensional scanni...

Embodiment 2

[0067] (1) Tablet core prescription:

[0068]

[0069]

[0070] (2) Prescription of semi-permeable membrane coating solution:

[0071]

[0072] (3) Preparation process: Weigh the components that have passed through a 100-mesh sieve according to the prescription and mix them evenly; finally add the prescribed amount of magnesium stearate, mix evenly, and press into tablets; Coating until the weight gain of the tablet core is 4%; use a laser to punch a small hole with a diameter of 0.8 mm on one side of the coated tablet.

[0073] (4) Measuring method: Paddle method is adopted, 900mL degassed distilled water is used as release medium, and the rotating speed is 75 revolutions per minute. The release degree at different time points was measured, and the osmotic pump tablets were taken out at different dissolution time points, sealed in a desiccator filled with a desiccant (silica gel) at room temperature, and placed for 48 hours. Acquire two-dimensional images with a 180-...

Embodiment 3

[0076] (1) Tablet core prescription:

[0077]

[0078]

[0079] (2) Prescription of semi-permeable membrane coating solution:

[0080]

[0081] (3) Preparation process: Weigh the components that have passed through a 100-mesh sieve according to the prescription and mix them evenly; finally add the prescribed amount of magnesium stearate, mix evenly, and press into tablets; Coating until the weight gain of the tablet core is 4%; use a laser to punch a small hole with a diameter of 0.8 mm on one side of the coated tablet.

[0082] (4) Measuring method: Paddle method is adopted, 900mL degassed distilled water is used as release medium, and the rotating speed is 75 revolutions per minute. The release degree at different time points was measured, and the osmotic pump tablets were taken out at different dissolution time points, sealed in a desiccator filled with a desiccant (silica gel) at room temperature, and placed for 48 hours. Acquire two-dimensional images with a 18...

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Abstract

The invention provides a novel medicine osmotic pump preparation, which comprises a tablet core and a coating membrane, wherein on the basis of the total weight of the tablet core, the tablet core comprises 1 to 60 weight percent of medicine, 5 to 90 weight percent of cavity structure forming materials, 1 to 50 weight percent of cavity structure shape modifiers, 0.5 to 10 weight percent of lubricating agents and 1 to 60 weight percent of pharmaceutically acceptable auxiliary materials, and on the basis of the total weight of the coating membrane, the coating membrane comprises 40 to 90 weight percent of semipermeable membrane coating materials, 5 to 40 weight percent of pore-foaming agents and 0 to 20 weight percent of plasticizers. The cavity structure forming materials can form micro-cell-shaped, poriform or saccular cavity structures inside the tablet core after meeting water, and the control on the medicine release speed is realized through regulating and controlling the form, the size and the evolution speed of micro cavity structures. The osmotic pump preparation is applicable to water-soluble medicine and water-insoluble medicine, in particular to the control release of low-solubility medicine or pH dependency medicine.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a novel drug osmotic pump preparation with a special internal fine chamber structure. The osmotic pump preparation of the new structure type is suitable for easily water-soluble drugs and poorly water-soluble drugs, and is especially suitable for controlled-release administration of low-soluble drugs. Background technique [0002] Osmotic pump preparations have the characteristics of constant release, which can avoid the fluctuation of blood drug concentration caused by the administration of common preparations, reduce the side effects on the gastrointestinal tract and the whole body, and their release characteristics are less affected by variable factors in the gastrointestinal tract , the different macroscopic structures of osmotic pumps and their applications have been rapidly developed and valued. Hundreds of domestic and foreign patents have focused on the macrosco...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/36A61K9/32A61K9/22
CPCA61K9/2853A61K9/0004A61K31/192A61K31/205A61K31/401A61K31/407A61K31/513A61K31/519A61K31/522A61K31/64A61K31/7052A61K31/7056A61K9/2866A61K31/40A61K47/32G01N23/046
Inventor 张继稳伍丽殷宪振郭桢李海燕
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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