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Biological composite material and capsule prepared from biological composite material

A composite material and biological technology, which is applied to the biological composite material and its application field, and achieves the effect of simple method, improved mechanical properties and thermal stability.

Active Publication Date: 2013-01-16
钟春燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no report on the use of biocellulose for the production of capsules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: Preparation of biocomposite material

[0018] Using Acetobacter xylinum as the strain, the biocellulose gel was prepared by static shallow plate fermentation culture (30°C, 7 days). After repeated washing to remove residual medium and bacteria, vacuum freeze-drying and crushing into dry biocellulose gel powder.

[0019] Take glycerin and add water to prepare a glycerol aqueous solution with a concentration of 10 wt%.

[0020] Get above-mentioned aqueous glycerin solution 4500g, gellan gum 3000g, starch 1000g and above-mentioned biological cellulose gel dry powder 1500g mix, use homogenizer under the rotating speed of 15000rpm, homogenize 30 minutes, leave standstill 2 hours after degassing, make Obtain the biocomposite material among the present invention.

[0021]

Embodiment 2

[0022] Embodiment 2: the preparation of biocomposite material

[0023] Using Acetobacter xylinum as the strain, the biocellulose gel was prepared by static shallow plate fermentation culture (28°C, 8 days). After repeated washing to remove residual medium and bacteria, vacuum freeze-drying and crushing into dry biocellulose gel powder.

[0024] Get glycerin and add water to prepare a glycerol aqueous solution with a concentration of 20 wt%.

[0025] Get 6500g of glycerin aqueous solution, 1000g of gellan gum, 500g of starch, and 2000g of the above-mentioned broken biocellulose gel and mix them, use a homogenizer at a speed of 20,000rpm, homogenize for 20 minutes, and let stand for 1 hour after degassing to obtain this product. Invention biocomposites.

[0026]

Embodiment 3

[0027] Embodiment 3: the preparation of biocomposite material

[0028] The biocellulose gel was prepared by dynamic fermentation culture (30℃, 5 days, shaker culture) with Gluconacetobacter xylinum as the strain. After repeated washing to remove residual medium and bacteria, vacuum freeze-drying and crushing into dry biocellulose gel powder.

[0029] Get glycerin and add water to prepare the glycerin aqueous solution that concentration is 15wt%.

[0030] Take 5000g of glycerol aqueous solution, 2500g of gellan gum, 1000g of broken biocellulose gel of starch 1500g and mix them, use a homogenizer at a speed of 18000rpm, homogenize for 25 minutes, and let stand for 1.5 hours after degassing to obtain the present invention. biocomposite materials.

[0031]

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PUM

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Abstract

The invention relates to a biological composite material compounded by biological cellulose gel dry powder, gellan gum, starch and the like and a capsule prepared from the biological composite material. The biological composite material is formed by mixing the biological cellulose gel dry powder, gellan gum, starch and a glycerine aqueous solution, homogenizing, degassing and standing. According to the invention, the biological cellulose gel dry powder, gellan gum and starch are compounded, the obtained biological composite material is taken as raw material of a capsule case for making a capsule, a method is simple, good effect can be still obtained without adding other gelatinizing agents, and mechanical performance and thermal stability of the obtained capsule shell can be obviously improved.

Description

technical field [0001] The application relates to a biocomposite material and its application, in particular to a biocomposite material composed of biocellulose gel dry powder, gellan gum, starch, etc., and a capsule made of it. Background technique [0002] Capsules are a pharmaceutical dosage form made by encapsulating active ingredients with edible materials. Current capsules mainly include gelatin capsules with gelatin as the main material of the capsule shell and plant fibers with vegetable cellulose (such as hydroxypropyl methylcellulose) as the main material of the capsule shell. However, gelatin capsules have low water content and poor mechanical properties, resulting in high brittleness, and are easily broken when filled with medicines. At the same time, they cannot be filled with hygroscopic medicines. In addition, gelatin is a kind of animal protein colloid, which contains a certain amount of animal fat, which is easy to cause pollution due to animal-derived dise...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L1/02C08L5/00C08L3/02C08K5/053A61K9/48A61K47/36A61K47/38
Inventor 钟春燕
Owner 钟春燕