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Temporal intraluminal stent, methods of making and using

A polymer tube, tubular structure technology, applied in stents, other medical devices, pharmaceutical sciences, etc., can solve the problem of lack of mechanical strength, elastic polymer recoil, etc., and achieve the effect of improving radiopacity

Active Publication Date: 2013-01-23
BIOSENSORS INT GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, biodegradable scaffolds have the following typical disadvantages: lack of mechanical strength and / or undesired physical / mechanical recoil of elastic polymers

Method used

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  • Temporal intraluminal stent, methods of making and using
  • Temporal intraluminal stent, methods of making and using
  • Temporal intraluminal stent, methods of making and using

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0116] Preparation of biodegradable polymer tubes

[0117] The biodegradable polymer tube was prepared by immersing the mandrel in a biodegradable polymer solution (12% by weight of PLLA in CCl 3 H (chloroform) solution) to form a coating layer by layer on a mandrel. The mandrel was dipped 46 times in the PLLA solution at a rate of about 0.1 m / s.

[0118] The dip-coated mandrel was then spin-dried around its longitudinal axis in a laminar flow hood to obtain a thin polymer layer after evaporation of the solvent. Repeat for spin drying. The final polymer tube was approximately 0.2mm thick and had 6% by weight phosphate buffer. The polymer coating was then solvent polished using chloroform or a pure solvent capable of dissolving the polymer and resulting in a thin and smooth polymer tube coating after drying.

[0119] The thickness of the outer diameter of the scaffold is reduced while maintaining the same inner diameter of the scaffold by stretching the tube scaffold from t...

Embodiment 2

[0123] Scaffold Design and Fabrication

[0124] Design the pattern of the scaffold using CAD software. Graphic designs and uncut biodegradable polymer tubing are sent to the laser lab for laser cutting. A variety of commercially available laser cutting equipment can be used, eg, Resonetics (Nashua, NH) and Spectralytics (Dassel, MN). Stent designs were cut from biodegradable polymer tube stents with an excimer laser at wavelengths less than 310 nm.

[0125] Those skilled in the art will appreciate that the stents of the invention disclosed in the disclosed embodiments or variations thereof have mechanical and therapeutic advantages over conventional stents. Furthermore, beneficial treatments would suggest that practitioners in the art employ them in view of the foregoing description of the invention. Due to the advantages of the biodegradable polymeric nature of the stent of the present invention, the same vessel site can be reprocessed at a later time if desired, including...

Embodiment 3

[0127] Radiopaque stents with iodine-containing contrast media

[0128] A PLLA polymer scaffold with a PLLA fiber diameter of 0.01905 cm and a fiber length of 15-22 cm and a length of 0.8-1.2 cm was used. Dissolve iohexol in methanol to a concentration of 350 mg / mL. Then, pure iohexol solution was sprayed on the top layer of the PLLA scaffold to a coating thickness of about 0.01″. The dose measured on all scaffold samples was 1000 μm / stent. When the methanol evaporated, the iohexol completely covered The surface of the near-chamber stent was exposed. After being exposed to water for 30 seconds, the radiopacity of the coated stent was observed under the C-arm (c-arm), and the results were as follows Figure 13 (#4). A control stent made of pure PLLA was also tested for radiopacity (#1).

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Abstract

The invention relates to a temporal intraluminal stent, and methods of making and using. Specifically, a biodegradable polymer stent with radiopacity and a method of making and using a stent with enhanced mechanical strength and / or controlled degradation for use in a bodily lumen is described.

Description

[0001] This application is a divisional application of the international application filed on October 24, 2007 with the application number PCT / US2007 / 022577 and the title of the invention "Temporary intraluminal stent and its preparation and use method". The international application was filed in 2009 It entered the Chinese national phase on June 16, 2007, with the application number 200780046519.1. technical field [0002] The present invention relates to a radiopaque biodegradable polymer scaffold and methods for its preparation and use. Background technique [0003] A stent is an intimal prosthetic implant, usually tubular, typically having an open or lattice tubular structure that is expandable and capable of being inserted into an anatomical lumen to provide mechanical support for the lumen and to A flow channel is maintained or reestablished within the lumen. For example, stents are known to be used in blood vessels such as the aorta, carotid, coronary or artery to tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/915A61F2/91A61M31/00A61F2/82
CPCA61F2002/91591A61F2/915B29C41/34A61F2/86A61F2/88B29K2067/046B29C41/14A61F2/91A61F2002/91525A61F2210/0076A61F2002/91541A61F2002/91558A61F2002/91566A61F2002/828A61L27/14A61F2/82A61L27/54A61L27/28
Inventor S-H·苏J·E·舒尔茨D·杜塔J·阮
Owner BIOSENSORS INT GROUP
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