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Medicinal composition containing ceftiofur bisbenzylethylenediamine

A technology for thiifurobisbenzylethylenediamine salt and cephalosporin, which is applied in the field of veterinary drug preparations, can solve the problems of not recognizing active ingredients and the like, and achieves the effects of long drug effect maintenance time, good drug effect and good stability

Inactive Publication Date: 2013-01-23
LUOYANG HUIZHONG ANIMAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But it is only used as an intermediate for the preparation of ceftiofur sodium, and it has not been recognized that it can be used as an active ingredient as a pharmaceutical preparation

Method used

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  • Medicinal composition containing ceftiofur bisbenzylethylenediamine
  • Medicinal composition containing ceftiofur bisbenzylethylenediamine
  • Medicinal composition containing ceftiofur bisbenzylethylenediamine

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Embodiment 1

[0052] Prepare the suspension injection of ceftiofur bisbenzylethylenediamine salt according to the following components:

[0053]

[0054]

[0055] Wherein the ceftiofur bisbenzylethylenediamine salt is ultra-micronized, and the method is as described above.

[0056] According to the above formula, the method for preparing the ceftiofur bisbenzylethylenediamine salt suspension injection is as follows: the suspending agent is prepared into a solution according to the above ratio, and set aside. Dissolve the wetting agent, buffering agent and antioxidant in water according to the above ratio, and prepare solution a for future use. Add the suspension to liquid a to obtain liquid b. Adjust the pH to 7.0 ± 0.5 with sodium citrate solution. Add micronized ceftiofur bisbenzylethylenediamine salt, dilute to 1 mL with water for injection, and obtain three batches of samples—sample 1, 2 and 3.

[0057] Drug efficacy, irritation and stability tests are carried out on sample 1 b...

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Abstract

The invention provides a suspension injection of ceftiofur bisbenzylethylenediamine, which comprises the following components: 1.2% to 12.6% (w / v) of superfine powdery ceftiofur bisbenzylethylenediamine and 0.1% to 25% (w / v) of buffering agent, and the invention also provides the preparation steps of the suspension injection of ceftiofur bisbenzylethylenediamine. The invention discloses the suspension injection of ceftiofur bisbenzylethylenediamine and the medicinal value of the suspension injection of ceftiofur bisbenzylethylenediamine, namely at least the efficacy of ceftiofur is achieved. The suspension injection of ceftiofur bisbenzylethylenediamine provided by the invention can be prepared into the easily absorbed aqueous liquid dosage forms for treating bacterial respiratory infection of livestock, such as the preparation and oral liquid. Compared with the prior art, the suspension injection has the advantages that at least a step of preparing ceftiofur sodium by ceftiofur bisbenzylethylenediamine is saved, and the problems that the preparation steps of ceftiofur sodium are complicated and the cost is high are avoided.

Description

technical field [0001] The invention relates to a suspension injection of ceftiofur bisbenzylethylenediamine salt, a preparation method and application thereof, and belongs to the field of veterinary drug preparations. Background technique [0002] Ceftiofur, also known as ceftiofur, chemical name: (6R,7R)-7-[2-(2-aminothiazol-4-yl)-(Z)-(methoxyimino)acetamide Base]-3-[(2-furylcarbonyl)thiomethyl]-3-cephem-4-carboxylic acid is the first animal-specific cephalosporin antibiotic created by the American weight West Upstrong Company . Since it was approved by the FDA in 1988 for the treatment of respiratory infections in cattle, it has been widely used in veterinary clinics at home and abroad because of its excellent antibacterial activity and dynamic process in vivo. [0003] The mechanism of action of ceftiofur is the same as that of other β-lactam drugs. It can bind to bacterial receptor binding proteins (PBPs), inhibit bacterial cell wall synthesis of transpeptidase, carbo...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K9/10A61P31/04A61P11/00
Inventor 张许科刘兴金张晓会
Owner LUOYANG HUIZHONG ANIMAL MEDICINE
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