Compound trimethoprim and doxycycline hydrochloride nanoemulsion preparation and preparation method thereof

A technology of doxycycline hydrochloride and compound trimethoprim, which is applied in the directions of tetracycline active ingredients, emulsion delivery, antibacterial drugs, etc., to achieve the effects of rapid absorption, low side effects and good stability

Inactive Publication Date: 2013-01-30
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After the bacteria develop drug resistance, not only the curative effect will be reduced, but also the spread of drug-resistant strains will be caused, which will bring difficulties to the treatment

Method used

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  • Compound trimethoprim and doxycycline hydrochloride nanoemulsion preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A kind of compound recipe trimethoprim and doxycycline hydrochloride nanoemulsion preparation, this nanoemulsion preparation is made of 0.003g trimethoprim, 0.012g doxycycline hydrochloride, 9.0g surfactant EL-40, 3.0g auxiliary surface Active agent PG, 1.2g IPM, 12g distilled water.

[0024] The preparation method of described compound recipe trimethoprim and doxycycline hydrochloride nanoemulsion preparation, it may further comprise the steps:

[0025] 1) Weigh each raw material separately in proportion; add the trimethoprim raw material drug into the co-surfactant (PG) and mix evenly, properly ultrasonic emulsify until the trimethoprim is completely dissolved, and then add the surfactant (EL-40) and oil (IPM), stir and mix to obtain system a, set aside;

[0026] 2) Dissolve the doxycycline hydrochloride bulk drug in distilled water to obtain solution b, which is set aside;

[0027] 3) Slowly add solution b to system a dropwise at room temperature, while stirring co...

Embodiment 2

[0029] A kind of compound recipe trimethoprim and doxycycline hydrochloride nanoemulsion preparation, this nanoemulsion preparation is made up of 0.03g trimethoprim, 0.12g doxycycline hydrochloride, 3.0g surfactant Tween-80, 1.0g auxiliary Surfactant ethanol, 0.44g IPM, 8.0g distilled water.

[0030] Refer to Example 1 for the preparation method of the compound trimethoprim and doxycycline hydrochloride nanoemulsion preparation.

Embodiment 3

[0032] A kind of compound recipe trimethoprim and doxycycline hydrochloride nanoemulsion preparation, this nanoemulsion preparation is made of 0.4g trimethoprim, 1.6g doxycycline hydrochloride, 6.0g surfactant EL-40, 2.0g auxiliary surface The active agent is ethanol, 0.88g ethyl acetate, and 12g distilled water.

[0033] Refer to Example 1 for the preparation method of the compound trimethoprim and doxycycline hydrochloride nanoemulsion preparation.

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Abstract

The invention discloses a compound trimethoprim and doxycycline hydrochloride nanoemulsion preparation. The nanoemulsion preparation is of an oil-in-water type, and the grain size of the nanoemulsion preparation is between 1nm and 100nm. The nanoemulsion preparation is prepared from the following raw materials in weight percentage: 0.01-1.75 percent of trimethoprim, 0.04-6.99 percent of doxycycline hydrochloride, 21.8-35.7 percent of surfactant, 7.94-11.9 percent of cosurfactant, 3.49-4.76 percent of oil and the balance of distilled water. The compound preparation is an oil-in-water type nanoemulsion; the compound preparation is flaxen and transparent in appearance; the grain size of the compound preparation is between 1nm and 100nm, so that the stability is high; and the trimethoprim and the doxycycline hydrochloride in the preparation show up an obvious synergistic effect, The compound nanoemulsion preparation has the advantages of safety, broad spectrum, high efficiency, targeting and slow release.

Description

Technical field [0001] The invention belongs to the veterinary drug field and involves a new dosage type antibacterial drug, which specifically involves a compound methaxilidine and polyxide nanoplasmic nanoplastic agent and its preparation methods. Background technique [0002] Antibacterial drugs have the advantages of fast results and low production costs in the treatment of animal infectious diseases, making it widely used in veterinarians.However, the limitations of traditional dosage forms and the gradual increase of drug resistance have increased their treatment costs and decreased curative effects.To this end, two or more antibacterial drugs are often used in clinical practice to achieve the purpose of expanding antibacterial spectrum, enhancing the efficacy, reducing the amount of medication, reducing or avoiding toxic side effects, and reducing or delaying the production of drug -resistant strains. [0003] Pyoxide (TMP) belongs to synthetic broad -spectrum antibacteri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/65A61K31/505A61K9/107A61P31/04
Inventor 胡帅樊楠李坤鹏
Owner HENAN SOAR VETERINARY PHARMA
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