Unlock instant, AI-driven research and patent intelligence for your innovation.

Aldehyde group modified gelatin material and preparation method thereof

A modified material, gelatin technology, applied in the direction of capsule delivery, inactive components of polymer compounds, etc., can solve the problems of swelling rate and disintegration rate, unable to achieve non-aging of capsule shell, and reduced hydrophilicity of modified gelatin. , to achieve the effect of enhancing hydrophilicity, solving aging problems, and good thermal reversibility

Active Publication Date: 2013-02-13
INST OF CHEM CHINESE ACAD OF SCI +1
View PDF3 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among many methods, the most widely used method is to add antioxidants (such as glycine and citric acid, etc., which are widely used at present) to the soft capsule shell material, but the addition of small molecule substances and the pharmaceutical ingredients in the capsule shell are complex. The potential reaction between traditional Chinese medicine preparations makes this method uncertain about safety and other issues, and the addition of antioxidants cannot ensure that the capsule shell does not age for a long time
There are also studies on chemical modification of gelatin, such as acylated gelatin, which acylates free amino groups in gelatin, but the modified gelatin formed by this method has reduced hydrophilicity, swelling rate and disintegration rate.
Although these methods have been improved to a certain extent, the effect is not very satisfactory, and the aging problem of gelatin soft capsules has not been fundamentally solved.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Aldehyde group modified gelatin material and preparation method thereof
  • Aldehyde group modified gelatin material and preparation method thereof
  • Aldehyde group modified gelatin material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The raw materials are bone type B medicinal gelatin, PEG-CHO with an average molecular weight of 4000, sodium borohydride, hydrochloric acid, sodium hydroxide and water. Wherein, the molar equivalent ratio of free amino groups and PEG-CHO in raw gelatin is 1:1, the molar equivalent ratio of free amino groups and sodium borohydride in raw gelatin is 1:0.4, and the mass ratio of water and gelatin is 33:1. Gelatin was dissolved in water at 60°C to form a clear solution. Dissolving PEG-CHO in water and adding it to the dissolved gelatin aqueous solution, the total water used by these two parts is 33 times the gelatin mass. Then add sodium borohydride, and use hydrochloric acid and sodium hydroxide to adjust the pH of the solution to keep it neutral, that is, pH=7. The homogeneous aqueous solution was magnetically stirred at 65°C for 20 hours, 24 hours and 48 hours respectively, then cooled to room temperature, and most of the water was distilled off under reduced pressure ...

Embodiment 2

[0048] The raw materials are bone type B medicinal gelatin, PEG-CHO with an average molecular weight of 200, hydrochloric acid, sodium hydroxide and water. Wherein, the molar equivalent ratio of free amino groups and PEG-CHO in the raw material gelatin is 1:0.8, and the mass ratio of water to gelatin is 20:1. Gelatin was dissolved in water at 50°C to form a clear solution. Dissolve PEG-CHO in water and add to the dissolved gelatin aqueous solution. The total water used by these two parts is 20 times the gelatin mass. Use hydrochloric acid and sodium hydroxide to adjust the pH of the solution to keep it neutral, that is, pH=7.5. The homogeneous aqueous solution was mechanically stirred at 40°C for 30 hours, cooled to room temperature, and most of the water was distilled off under reduced pressure at 60°C, and then dried in an oven at 50°C to obtain a modified gelatin material.

Embodiment 3

[0050] The raw materials are bone type B medicinal gelatin, PEG-CHO with an average molecular weight of 6000, sodium borohydride, hydrochloric acid, sodium hydroxide and water. Wherein, the molar equivalent ratio of free amino groups in raw gelatin to PEG-CHO is 1:0.5, the molar equivalent ratio of free amino groups in raw gelatin to sodium borohydride is 1:0.125, and the mass ratio of water to gelatin is 100:1. Gelatin was dissolved in water at 40°C to form a clear solution. Dissolve PEG-CHO in water and add to the dissolved gelatin aqueous solution. The total water used by these two parts is 100 times the gelatin mass. Then add sodium borohydride, and use hydrochloric acid and sodium hydroxide to adjust the pH of the solution to keep it neutral, that is, pH=5.0. The homogeneous aqueous solution was mechanically stirred at 60°C for 35 hours, cooled to room temperature, and most of the water was distilled off under reduced pressure at 60°C, and then dried in an oven at 40°C t...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention discloses a modified gelatin material and a preparation method thereof, wherein the gelatin is subjected to aldehyde group modification, and the aldehyde group is single end-capping hydrophilic aldehyde, more preferably single end-capping PEG-CHO. Preferably the PEG can adopt alkoxy to carry out end capping, preferably C1-C6 alkoxy to carry out end capping, more preferably methoxy to carry out end capping. More preferably the material is prepared from the gelatin and the single end-capping PEG-CHO through a chemical reaction, wherein preferably an equivalent weight ratio of free amino groups in the gelatin to the aldehyde groups in the single end-capping PEG-CHO in the raw material is 1:0.5-1:2, preferably 1:0.7-1:1.5, more preferably 1:0.8-1:1.1. The modified gelatin material has characteristics of stable properties, good solubility in water and a buffer solution, no toxicity, pharmaceutical prospects and simple preparation method.

Description

technical field [0001] The invention relates to a modified gelatin material, in particular to a modified gelatin material comprising single-capped PEG-CHO modified mammalian type B gelatin and a preparation method thereof. Background technique [0002] Soft capsules have the characteristics of good sealing, high bioavailability, accurate content, and beautiful appearance. Once they appeared, they were favored by formulation researchers and pharmaceutical companies and developed rapidly. Domestic soft capsules were introduced in the early 1970s, and were also sought after by domestic scientific researchers, making Chinese medicine soft capsules obtain unprecedented development. At present, many kinds of traditional Chinese medicine soft capsules have been developed and put into the market, such as Huoxiangzhengqi soft capsules and compound salvia miltiorrhiza soft capsules. [0003] Gelatin is widely used as the outer shell material of soft capsules because of its glossy app...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C08H1/02C08H1/06A61K9/48A61K47/42
Inventor 邱东王晨刘淑芝杜茂波
Owner INST OF CHEM CHINESE ACAD OF SCI