Triple cross-linking collagen, preparation method and uses thereof

A collagen and manufacturing method technology, applied in dental preparations, pharmaceutical formulations, dental prostheses, etc., can solve the problems of anti-enzyme decomposition that cannot meet expectations, low cross-linking degree, uneven cross-linking, etc.
CN102924731AActive Publication Date: 2013-02-13SUNMAX BIOTECH
3 Cites 18 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUNMAX BIOTECH
Publication Date
2013-02-13

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to a triple cross-linking collagen preparation method, which comprises: providing a soluble collagen sample, mixing the collagen sample and a first cross-linking agent to form a single cross-linking collagen, mixing the single cross-linking collagen and a second cross-linking agent to form a double cross-linking collagen, and mixing the double cross-linking collagen and a third cross-linking agent to form the triple cross-linking collagen, wherein the first cross-linking agent, the second cross-linking agent and the third cross-linking agent are separately selected from a group comprising an aldehyde cross-linking agent, an imine cross-linking agent and an epoxide cross-linking agent, the first cross-linking agent is different from the second cross-linking agent, and the third cross-linking agent is different from the first cross-linking agent and the second cross-linking agent.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The present invention mainly relates to a method for producing triple cross-linked collagen, especially a triple cross-linked collagen suitable for manufacturing high melting point, low enzymatic degradation rate, and high stability, and the triple cross-linked Collagen is used in medical treatments that require long-term implantation of collagen. Background technique

[0002] Collagen exists in the connective tissue of the human body and is the structural matrix of tissues and organs such as bones, cartilage, tendons, ligaments, blood vessels, corneas, basement membranes, and skin. Collagen is often used in medical treatment and tissue engineering to strengthen or protect human tissues due to its low immune response.

[0003] However, related medical materials mainly composed of collagen are usually degraded by enzymes in the body within a short period of time after being implanted into the human body, and then metabolized and disappear. Therefore, m...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More