Block polymer, preparation method thereof and electrically active hydrogel

A block copolymer, electroactive technology, applied in electrodes, electrotherapy, adhesives, etc., can solve the problem that injectable hydrogels do not have electroactivity, and achieve good electrochemical response characteristics and good water solubility.

Active Publication Date: 2013-03-13
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, none of the injectable hydrogels prepared by the prior art is electroactive

Method used

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  • Block polymer, preparation method thereof and electrically active hydrogel
  • Block polymer, preparation method thereof and electrically active hydrogel
  • Block polymer, preparation method thereof and electrically active hydrogel

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preparation example Construction

[0056] The present invention also provides a kind of preparation method of block copolymer, comprises the following steps:

[0057] A) Mix terminal aminated polyethylene glycol monomethyl ether or terminal aminated polyethylene glycol with benzyl glutamate-N-carboxylic acid anhydride or benzyloxycarbonyl-lysine-N-carboxylic acid anhydride to carry out Ring-opening polymerization, followed by deprotection to obtain a polyglutamic acid block copolymer intermediate or a polylysine block copolymer intermediate;

[0058] B) Mix the polyglutamic acid block copolymer intermediate obtained in step A) with a coupling reagent and a compound having the structure of formula (Ⅴ) to undergo a condensation reaction to obtain a polyglutamic acid block copolymer; ) The obtained polylysine block copolymer intermediate is mixed with a coupling reagent and a compound having the structure of formula (VI), and a condensation reaction occurs to obtain a polylysine block copolymer;

[0059]

[00...

Embodiment 1~3

[0142] First, 1 g of polyethylene glycol monomethyl ether with a number average molecular weight of 1000, 10000, and 20000 and 5 mL of toluene were azeotroped to remove water at 140 ° C, and the toluene was evaporated under reduced pressure to dissolve polyethylene glycol monomethyl ether with 10 mL of dichloromethane. ether to obtain a polyethylene glycol monomethyl ether solution, and then add triethylamine to the polyethylene glycol monomethyl ether solution at 0°C under anhydrous conditions according to the ratio in Table 1, and add methanesulfonyl chloride dropwise, After the dropwise addition, react at 0°C for 2 hours, then stir at room temperature for 24 hours, filter to remove the precipitate after the reaction, settle the filtrate with ether, filter to obtain a solid, and vacuum dry at room temperature for 24 hours to obtain polyethylene glycol methylsulfonate methyl ether ester. Table 1 shows the proportions of polyethylene glycol monomethyl ether, triethylamine and ...

Embodiment 4~6

[0147] First, 1 g of polyethylene glycol with a number average molecular weight of 1000, 10000, and 20000 and 5 mL of toluene were azeotroped to remove water at 140 ° C, and the toluene was evaporated under reduced pressure. After the toluene was evaporated, polyethylene glycol was dissolved in 10 mL of dichloromethane to obtain polyethylene glycol. solution, and then according to the ratio in Table 2, triethylamine was added to the polyethylene glycol solution at 0°C under anhydrous conditions, and methanesulfonyl chloride was added dropwise. After the dropwise addition, the reaction was carried out at 0°C for 2h Then the reaction was stirred at room temperature for 24 hours. After the reaction was completed, the precipitate was removed by filtration. The filtrate was settled with ether, and the solid was obtained by filtration. After vacuum drying at room temperature for 24 hours, polyethylene glycol methanesulfonate was obtained respectively. Table 2 shows the proportions of...

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Abstract

The invention provides a block polymer which comprises a block A having a structure shown in formula (I) or formula (II) and a block B having a structure shown in formula (III) or formula (IV). When a polyglutamic acid block polymer and a polylysine block polymer prepared by the invention are mixed in a water-based medium, the solution can be immediately transformed into an ionic composite electrically active hydrogel material. According to the invention, the block B having the structure shown in formula (III) or formula (IV) contains an aniline oligomer segment and bears an intermolecular pi-pi acting force by itself, and conjugated pi electrons are electric-conductive, so that the prepared block polymer has favorable electrochemical response characteristic; and meanwhile, micelle formed by the block A and the block B which have a certain chain link number ratio is water-soluble, thereby ensuring that the block polymer provided by the invention also has favorable water solubility.

Description

technical field [0001] The invention relates to the technical field of biomedical polymer materials, in particular to a block copolymer, its preparation method and electroactive hydrogel. Background technique [0002] Hydrogel is a kind of polymer with a cross-linked network structure that can absorb and retain a large amount of water. The polymer network structure contains hydrophilic groups or hydrophilic segments, which can combine with water in an aqueous environment. Thus, a hydrogel structure is formed, which allows small hydrophilic molecules to diffuse in it. [0003] Injectable hydrogel is a new type of hydrogel system that has emerged in recent years. It has unique solution-gel transition characteristics, so biomaterials with certain fluidity can be implanted into the body by injection, and filled with the whole body. Irregularly shaped defects. This type of hydrogel has the characteristics of good fluidity, convenient use, long residence time, small wound, and s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G69/48C08G69/40A61K47/34A61K9/06A61K50/00
Inventor 陈学思崔海涛刘亚栋庄秀丽
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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