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A kind of graft copolymer, its preparation method and layer-by-layer modification material

A graft copolymer and modified material technology, applied in the field of graft copolymer, its preparation method and layer-by-layer modified materials, can solve the problems of no electrical activity, etc., achieve good water solubility, good electrochemical response characteristics, composite good effect of layers

Active Publication Date: 2016-01-20
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, none of the tissue engineering materials disclosed in the prior art has electrical activity

Method used

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  • A kind of graft copolymer, its preparation method and layer-by-layer modification material
  • A kind of graft copolymer, its preparation method and layer-by-layer modification material
  • A kind of graft copolymer, its preparation method and layer-by-layer modification material

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preparation example Construction

[0057] The present invention also provides a kind of preparation method of graft copolymer, comprising:

[0058]A) Mix the initiator with the acid anhydride in the amino acid ring, carry out ring-opening polymerization, and then deprotect to obtain polyglutamic acid copolymer or polylysine copolymer, the initiator is selected from n-hexylamine or triethylamine , the acid anhydride in the amino acid ring is selected from benzyl glutamate-N-carboxylic acid anhydride or benzyloxycarbonyl-lysine-N-carboxylic acid anhydride;

[0059] B) Mix the polyglutamic acid copolymer obtained in step A) with the coupling reagent and the compound having the structure of formula (III) to undergo a condensation reaction to obtain a polyglutamic acid graft copolymer; or mix the polyglutamic acid graft copolymer obtained in step A) The polylysine copolymer is mixed with the coupling reagent and the compound having the structure of formula (IV), and undergoes condensation reaction to obtain the poly...

Embodiment 1

[0131] Dissolve 3.68g (0.02mol) of N-phenyl-1,4-p-phenylenediamine in a mixture of 100mL acetone, 100mL water and 25mL concentrated hydrochloric acid to obtain N-phenyl-1,4-p-phenylenediamine mixed solution, and frozen to 0°C; then weighed 4.56g (0.02mol) of ammonium persulfate (APS) and dissolved it in 50mL of 1mol / L HCl aqueous solution to obtain an APS solution, and slowly dripped the APS solution into N-phenyl-1 in an ice bath, 4-p-Phenylenediamine mixed solution (dropped in about half an hour), reacted for 3 hours after dropping, then filtered to obtain a solid, then washed the solid with 0.6mol / L HCl aqueous solution and acetone, and filtered with 0.5mol / L ammonia water The solid is back-doped, and finally the solid is washed three times with water to neutrality, freeze-dried and then vacuum-dried to obtain aniline tetramer whose terminal group is an amino group. The yield was 80%.

Embodiment 2

[0133] Dissolve 3.5g of N-(4-anilino)-1,4-p-phenylenediamine and 2.6g of N,N-diphenyl-1,4-p-phenylenediamine in 100mL N,N-dimethylformamide , 15mL of water and 15mL of concentrated hydrochloric acid to obtain N-(4-anilino)-1,4-p-phenylenediamine and N,N-diphenyl-1,4-p-phenylenediamine mixed solution, and Freeze to 0°C; then weigh 2.28g (0.01mol) of ammonium persulfate APS and dissolve it in 50mL of 1mol / L HCl aqueous solution to obtain an APS solution, slowly drop the APS solution into N-(4-anilino)-1,4 - In the mixed solution of p-phenylenediamine and N,N-diphenyl-1,4-p-phenylenediamine (dropped in about half an hour), react for 1 hour after dropping, then pour the product into 700mL water for precipitation, The solid was obtained by filtration, the solid was washed three times with 0.1mol / L HCl aqueous solution and water successively, and then the solid was back-doped with 0.1mol / L ammonia water, and finally the solid was washed three times with water once to neutrality, and...

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Abstract

The invention provides grafted copolymer which is provided with a structure represented by the formula (1) or the formula (II). The grafted copolymer has good water solubility and good electrochemistry response characteristics due to the fact that the grafted copolymer is provided with electroactive aniline oligomer segments. Prepared grafted copolymer is adsorbed to the surfaces of materials which are subjected to preprocessing layer by layer so as to obtain the layer-by-layer decorative materials which have an adjustable composite layer number and good electroactivity. The layer-by-layer decorative materials, used as biomedical polymer materials, can be better applied to the field of tissue engineering like artificial organs or tissue repair representing by the formula (1) or the formula (II).

Description

technical field [0001] The invention relates to the technical field of biomedical polymer materials, in particular to a graft copolymer, its preparation method and a layer-by-layer modification material. Background technique [0002] Tissue engineering has made great progress in seed cells, three-dimensional scaffold materials, bioactive factors, tissue construction, implantation in vivo, etc., and has good industrialization prospects. The patient's treatment brought light. [0003] The three important factors of tissue engineering are materials, cells and signals. Scientific issues such as how to achieve the best interaction between materials and cells, and how materials and signals affect cell behavior have become research hotspots. It has been found that modifying and functionalizing the surface of traditional materials can greatly improve and regulate cell proliferation and differentiation. Therefore, various surface modification methods such as laser etching, plasma s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G69/48C08G69/10B32B27/34
Inventor 陈学思崔海涛刘亚栋庄秀丽
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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