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Pharmaceutical composition containing adenosine cyclophosphate compound and preparation method of pharmaceutical composition

A cyclic adenosine monophosphate compound and the technology of cyclic adenosine monophosphate, which are applied in the field of pharmaceutical compositions containing cyclic adenosine monophosphate compounds and their preparation, can solve the problems of poor water solubility, poor preparation stability, and poor resolubility of cyclic adenosine monophosphate, etc. Achieve the effect of good stability and resolubility, improved water solubility and simple formula

Inactive Publication Date: 2013-03-27
罗诚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this patent application solves the problem of poor water solubility of cyclic adenosine monophosphate to a certain extent, the stability of the preparation is still relatively poor
[0005] Due to the poor water solubility of cyclic adenosine monophosphate, it is easy to separate out when prepared as an aqueous injection, and the prepared freeze-dried preparation has poor resolubility and poor stability of the preparation, which poses a certain safety hazard for clinical application.

Method used

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  • Pharmaceutical composition containing adenosine cyclophosphate compound and preparation method of pharmaceutical composition
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  • Pharmaceutical composition containing adenosine cyclophosphate compound and preparation method of pharmaceutical composition

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Experimental program
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Effect test

Embodiment 1

[0029] Embodiment 1: the preparation method of crystal compound

[0030] 1. Prepare a solution according to the ratio of adding 40g cyclic adenosine monophosphate solid per liter of water, heat to 45°C, and stir until completely dissolved;

[0031] 2. Under a sound field with a frequency of 20KHz and an output power of 30W, add dropwise a mixed solvent of methanol, isopropanol and ether at 1°C while stirring, and the stirring speed is 120 rpm; the methanol, isopropanol and ether The volume ratio of the solvent is 2:2:1, and the volume of the mixed solvent of methanol, isopropanol and ether is twice that of the aqueous solution of cyclic adenosine monophosphate; the speed of adding the mixed solvent is 240ml / min;

[0032] 3. After adding the mixed solvent, stop the sound field and stirring, continue to cool down to 1°C, and let the crystal grow for 3 hours; after obtaining the crystal, filter it, wash it with absolute ethanol, and dry it in vacuum for 4 hours to obtain a crysta...

Embodiment 2

[0035] Embodiment 2: the preparation method of crystal compound

[0036] 1. Prepare the solution according to the ratio of adding 40g cyclic adenosine monophosphate solid per liter of water, heat to 60°C, and stir until completely dissolved;

[0037] 2. Under a sound field with a frequency of 25KHz and an output power of 60W, a mixed solvent of methanol, isopropanol and ether at 5°C was added dropwise while stirring, and the stirring speed was 180 rpm; the volume of the methanol, isopropanol and ether The ratio is 2:1:1; the volume of the mixed solvent of methanol, isopropanol and ether is 4 times that of the aqueous solution of cyclic adenosine monophosphate; the speed of adding the mixed solvent is 200ml / min;

[0038] 3. After the mixed solvent was added, the sound field and stirring were stopped, and the temperature was continued to drop to 5°C, and the crystal was left standing for 8 hours; after the crystal was obtained, it was filtered, washed with absolute ethanol, a...

Embodiment 3

[0040] Embodiment 3: the preparation method of crystal compound

[0041] 1. Prepare a solution according to the ratio of adding 42g cyclic adenosine monophosphate solid per liter of water, heat to 50°C, and stir until completely dissolved;

[0042] 2. Under a sound field with a frequency of 2KHz and an output power of 40W, add dropwise a mixed solvent of methanol, isopropanol and ether at 2°C while stirring, and the stirring speed is 160 rpm; the methanol, isopropanol and ether The volume ratio of the solvent is 4:2:1; the volume of the mixed solvent of methanol, isopropanol and ether is 3 times that of the aqueous solution of cyclic adenosine monophosphate; the speed of adding the mixed solvent is 100ml / min;

[0043] 3. After adding the mixed solvent, stop the sound field and stirring, continue to cool down to 1-5°C, and let the crystal grow for 3-8 hours; after obtaining the crystal, filter it, wash it with absolute ethanol, and dry it in vacuum for 4-8 hours to obtain Cyclo...

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Abstract

The invention relates to a pharmaceutical composition and particularly relates to a pharmaceutical composition containing adenosine cyclophosphate compound and a preparation method of the pharmaceutical composition. The composition contains adenosine cyclophosphate and sodium bicarbonate in a weight ratio of 1:(0.05-0.5), preferably 1:(0.1-0.25). The adenosine cyclophosphate is a crystalline compound; and an X-ray powder diffraction diagram of the crystalline compound, which is obtained by measuring through Cu-Ka rays, is as shown in a figure 1. The dosage form of the composition is hydro-acupuncture or lyophilized powder injection, preferably lyophilized powder injection. The pharmaceutical composition prepared by the invention is safe and stable and can satisfy the need of the clinical medication.

Description

technical field [0001] The invention relates to a pharmaceutical compound, in particular to a pharmaceutical composition containing cyclic adenosine monophosphate compound and a preparation method thereof. Background technique [0002] Nucleotides are a very important class of substances in life sciences, and are also important pharmaceutical intermediates. Cyclic adenosine monophosphate (adenosinecyclophosphate, cAMP) is a very important nucleotide drug, and it is one of the hotspots of current molecular biology research. In the process of protein synthesis, cAMP controls the transcription and translation of genes, acts as a "second messenger", and affects the activities of many enzymes and metabolic processes of cells, and can participate in various physiological and biochemical processes such as cell differentiation, canceration, and reversal It is a non-cardiac glycoside drug with obvious effect and less toxic and side effects. cAMP is closely related to diseases such ...

Claims

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Application Information

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IPC IPC(8): A61K31/7076A61K9/19A61K47/02A61P17/06A61P9/10A61P11/06A61P9/12A61P3/10A61P35/00C07H19/213C07H1/06
Inventor 罗诚
Owner 罗诚
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