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Pharmaceutical composition for treating gout disease, and preparation method thereof

A composition and technology for gout, applied in the field of pharmaceutical composition for treating gout and its preparation, can solve the problems of high toxicity and side effects, and achieve the effects of low drug toxicity, reasonable prescription, and overcoming large toxicity and side effects

Inactive Publication Date: 2013-03-27
彭军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs have defects in treatment. Although they can achieve the effect of controlling symptoms, they have relatively large toxic and side effects, such as fever, allergic rash, abdominal pain, diarrhea, leukopenia and thrombocytopenia, and even liver and kidney dysfunction. These have become clinically applied. bottleneck

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The raw materials used in this example are Codonopsis 1500g, Radix Astragali 1200g, Cinnamon 1250g, Eucommia ulmoides 1250g, Gentiana chinensis 800g, vine vine 800g, loofah 1000g, Achyranthes bidentata sichuan 1200g, Alisma 800g, peach kernel 1000g, safflower 1000g, Poria cocos 800g;

[0038] Its preparation method is:

[0039] Take the above raw materials, add water to decoct 3 times, each time add 6 times the amount of water to decoct for 2 hours, filter, collect the filtrate, add 95% ethanol until the alcohol content reaches 60%, let stand for 12 hours, filter, When the filtrate is concentrated to 60°C, the relative density is 1.15, spray-dried (inlet air temperature 180°C, outlet air temperature 100°C), dry extract powder is added with appropriate amount of lactose, granulated, dried, granulated, and bagged.

Embodiment 2

[0041] The raw materials used in this example are Codonopsis 1000g, Radix Astragali 900g, Cinnamon 1000g, Eucommia ulmoides 1000g, Gentiana japonica 600g, Loofah 800g, Sichuan Achyranthes bidentata 1000g, Alisma 600g, peach kernel 800g, safflower 800g, Poria cocos 600g;

[0042] Its preparation method is:

[0043] Take the raw material drug, add water to decoct twice, add 4 times the amount of water each time and decoct for 1 hour, filter, collect the filtrate, concentrate to a concentrated solution with a relative density of 1.10 at 60°C, spray dry (inlet air temperature 180°C, The air temperature is 100°C), the dry extract powder is added with appropriate amount of starch, granulated, dried, granulated, and packed into capsules.

Embodiment 3

[0045] The raw materials used in this example are Codonopsis 2000g, Radix Astragali 1500g, Cinnamon 1500g, Eucommia ulmoides 1500g, Gentiana 1200g, Rattan 1200g, Loofah 1200g, Achyranthes bidentata 1500g, Alisma 1000g, peach kernel 1200g, safflower 1200g, Poria cocos 1000g;

[0046] Its preparation method is:

[0047] Take the raw material drug, add water to decoct 4 times, add 8 times the amount of water to decoct for 3 hours each time, filter, collect the filtrate, concentrate to a concentrated solution with a relative density of 1.20 at 60°C, spray dry (inlet air temperature 180°C, The air temperature is 100°C), the dry extract powder is added with an appropriate amount of microcrystalline cellulose, granulated, dried, granulated, and compressed into tablets.

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PUM

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Abstract

The invention relates to a pharmaceutical composition for treating gout disease, and a preparation method of the pharmaceutical composition, belonging to the field of medicine. The pharmaceutical composition comprises the raw traditional Chinese medicines: dangshen, radix astragali, cinnamon, eucommia, gentiana macrophylla, tinospora sinensis merr and the like. The pharmaceutical composition has the effects of tonifying qi, nourishing blood, dispelling wind and eliminating dampness, and is used for clinically treating the gout disease.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating gout and a preparation method thereof. It belongs to the field of medicine. Background technique [0002] Gout is a group of diseases caused by long-term purine metabolism disorder and elevated blood uric acid that cause tissue damage. The clinical features are: hyperuricemia, recurrent episodes of acute arthritis, tophi formation, chronic arthritis and joint deformities, and renal uric acid stones and gouty renal parenchymal lesions in the late course of the disease. [0003] There are frequent severe pains in the joints of the lowest part of the human body, the "pain" that is too painful, and the pain blows away like a "wind" within 1-7 days, so it is called "gout". 40+ males are more common (95%), women are generally common after menopause, because estrogen has an inhibitory effect on the formation of uric acid; but the incidence rate will increase after menopause. Hyperuricemia ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/884A61P19/06
Inventor 彭军
Owner 彭军
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