Hard tissue repair and substitute material and preparation method thereof
A hard tissue and ceramic technology, applied in the field of hard tissue repair and replacement materials and their preparation, can solve the problems of low mechanical strength of single dual-phase calcium-phosphorus ceramics, and constraints on the clinical application of structural support of bone repair and replacement materials. The effect of promotion and application value, low cost and simple preparation method
Inactive Publication Date: 2014-06-25
CHONGQING MEDICAL UNIVERSITY
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Problems solved by technology
[0003] The invention provides a hard tissue repair and replacement material and a preparation method thereof, aiming at solving the problem that the mechanical strength of single dual-phase calcium-phosphorus ceramics is low, it is difficult to play a structural support role as a bone repair and replacement material, and clinical application is limited. greatly constrained problem
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preparation example Construction
[0014] The preparation method comprises the following steps:
[0015] In step S101, 63.16g 6-aminocaproic acid, 2.76g proline, 2.68g alanine, 2.96g phenylalanine, 1.8g lysine, 3.00g hydroxyproline and 100ml water were added to 250ml in a three-necked bottle with stirring device and nitrogen protection device;
[0016] In step S102, nitrogen protection and stirring are turned on, and the temperature is gradually raised to 200°C. After the dehydration is completed, the temperature is raised to 210°C. At this temperature, all the reactants are melted into a bright yellow and transparent melt;
[0017] In step S103, after the monomer is melted, the temperature is raised to 220°C to start the polymerization reaction for 3 hours, and 49.89 g of biphasic calcium phosphate ceramics with a content of 40% is added, and the temperature is raised to 230°C to react for 3 hours. After the reaction is completed, under the protection of nitrogen Cool to room temperature to obtain massive har...
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Abstract
The invention belongs to the technical field of a biological material and provides a hard tissue repair and substitute material and a preparation method thereof. The hard tissue repair and substitute material comprises biphasic calcium phosphate (BCP) in which polyamino acid (PAA) is added. The hard tissue repair and substitute material with good biological activity and enough mechanical strength is obtained by adding the polyamino acid to improve the mechanical strength of the biphasic calcium phosphate, thereby the problem that the single biphasic calcium phosphate has lower mechanical strength, is difficult to serve as the bone repair and substitute material to play a role in a structural support and is largely restricted in clinical application is solved. The preparation method is simple and lower in cost and has stronger practical applicability and higher popularization and application value.
Description
technical field [0001] The invention belongs to the technical field of biological materials, in particular to a hard tissue repair and replacement material and a preparation method thereof. Background technique [0002] At present, there are many kinds of biomaterials for hard tissue repair and replacement, but few of them can be successfully used clinically. The main reason is that the biological activity and mechanical strength of biomaterials cannot be well balanced, especially in terms of mechanical strength. to the requirements of clinical application. Biphasic calcium phosphate ceramics (biphasic calcium phosphate, BCP) is a biologically active material composed of hydroxyapatite and β-tricalcium phosphate, which combines the high strength, high biological activity and stability of hydroxyapatite (HA) BCP has been extensively researched and widely used as a bone repair material for a long time because of its unique properties and the absorption and degradation propert...
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IPC IPC(8): A61L27/18A61L27/12
Inventor 蒋电明谯波李鸿严永刚曹侠郝新彦
Owner CHONGQING MEDICAL UNIVERSITY