High-yield Boldenone synthesis method
A synthesis method and technology of Boldenone, applied in the directions of steroids, organic chemistry, etc., can solve the problems of many by-products, low quality, low yield, etc., and achieve improved yield and quality, strong reaction selectivity, and economical cost effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0024] 1. Etherification reaction:
[0025] In a 300L reactor equipped with stirring, 72 kg of absolute ethanol and 42 kg of triethyl orthoformate were metered in, and then 75 kg of 1.4-ADD was added while stirring, and stirred for 5 minutes.
[0026] Adjust the temperature in the reactor to 39-42°C, then add 0.3 kg of pyridinium hydrobromide, start the reaction, record the time for 8 hours, add 1.0 Kg of triethylamine after the reaction, cool down to 0-5°C, and control the temperature at 0~5℃, keep stirring for 1 hour. When the reaction solution reaches neutrality, the etherification reaction is over, open the frozen brine, and freeze and crystallize at 0±2°C.
[0027] After the etherification reaction was terminated, the etherified compound was released from the reaction kettle, washed with 100 kg of absolute ethanol, and filtered by rejection to obtain a wet etherified compound.
[0028] 2. Reductive hydrolysis reaction:
[0029] In a 1000L washed and dried reaction pot,...
Embodiment 2
[0033] 1. Etherification reaction:
[0034] In a 300L reactor equipped with stirring, 75 kg of absolute ethanol and 45 kg of triethyl orthoformate were metered in, and then 76 kg of 1.4-ADD was added while stirring, and stirred for 5 minutes. Adjust the temperature in the reactor to 39-42°C, then add 0.2 kg of pyridinium hydrobromide, start the reaction, record the time for 8 hours, add 1.2 Kg of triethylamine after the reaction, cool down to 0-5°C, and control the temperature at 0~5℃, keep stirring for 1 hour. When the reaction solution reaches neutrality, the etherification reaction is over, open the frozen brine, and freeze and crystallize at 0±2°C.
[0035] After the etherification reaction was terminated, the etherified compound was released from the reactor, washed with 90 kg of absolute ethanol for a while, and filtered by rejection to obtain a wet etherified compound.
[0036] 2. Reductive hydrolysis reaction:
[0037] In a 1000L washed and dried reaction pot, put 6...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com