The invention relates to a high-yield Boldenone synthesis method. The method comprises the following steps of: 1, etherification reaction: adding absolute ethyl 
alcohol and 
triethyl orthoformate in a reaction kettle, stirring, adding 1.4-ADD, 
pyridine hydrobromide and 
triethylamine, freezing for 
crystallization, washing with absolute ethyl 
alcohol, and filtering in a swinging manner to get the wet etherate; 2, reduction and 
hydrolysis reaction: firstly, adding methyl 
alcohol in the reaction kettle, stirring, then, adding etherate 
pyridine and 
sodium borohydride, preserving heat for reaction, and carrying out 
thin layer chromatography, after the reduction reaction, regulating the temperature, regulating pH, concentrating the mixture to be in dense 
slurry form, adding water, cooling, centrifuging to get reduced 
hydrolysate, namely a Boldenone crude product, and 
drying; and 3, refining of crude product: adding the Boldenone crude product, methyl alcohol and water in the production kettle, heating with steam, cooling, and centrifuging. In the method, a new catalyst, namely 
pyridine hydrobromide, is used, thus, the yield and the quality of the product are improved. The method realizes one-step preparation of Boldenone, and in comparison with the DDQ (dihydro dicyan 
benzoquinone) 
dehydrogenation used in the past, the cost of products is saved in the synthesis method.