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High encapsulation rate curcumin albumin nano pharmaceutical composition

A composition and albumin technology, applied in the field of medicine, can solve the problems of reducing the metabolic rate, difficult to detect curcumin, etc., achieving good encapsulation efficiency, good water solubility and stability, enhancing drug targeting and slow release. Effect

Inactive Publication Date: 2013-04-24
CHANGZHOU TARGET MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Another important reason is that curcumin metabolizes too fast in the body, and it is still difficult to effectively reduce its metabolic rate in the blood to maintain an effective blood drug concentration by using conventional solubilization technology to make injections, such as glycerin formal of curcumin Half an hour after the solution was injected into the mice, the presence of curcumin was hardly detected in the blood [Ireson C, et al.Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatitis and in the rat in vivo, and evaluation of their ability to inhibit phorbolester-induced prostaglandin E2 production. Cancer Res 2001;61:1058.】

Method used

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  • High encapsulation rate curcumin albumin nano pharmaceutical composition
  • High encapsulation rate curcumin albumin nano pharmaceutical composition
  • High encapsulation rate curcumin albumin nano pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Reagents and materials: human serum albumin (Amresco distribution, biological reagent); 25% glutaraldehyde solution (Shanghai Chemical Reagent Purchasing and Supply Station, biochemical reagent); curcumin (provided by Shandong Target Drug Research Co., Ltd., purity determined by HPLC >99.0%). Other reagents are of domestic analytical grade.

[0029] Weigh 18.0g of HSA in a beaker, add 50ml of 0.9% physiological saline, stir, dissolve, and form HSA physiological saline solution for later use; Weigh 600.3mg of curcumin into a beaker, add 10ml of absolute ethanol, dissolve to make curcumin Absolute ethanol solution; dilute 25% glutaraldehyde solution to 2% glutaraldehyde solution. Place the HSA physiological saline solution in a constant temperature water bath at 30°C, while continuously stirring (480 rpm), add 10 ml of curcumin anhydrous ethanol solution to the HSA physiological saline solution, and continue to add 120 ml of anhydrous ethanol; add 2% pentanediol The ald...

Embodiment 2

[0031] Reagents and materials: human serum albumin (Amresco distribution, biological reagent); 25% glutaraldehyde solution (Shanghai Chemical Reagent Purchasing and Supply Station, biochemical reagent); curcumin (provided by Shandong Target Drug Research Co., Ltd., purity determined by HPLC >99.0%). Other reagents are of domestic analytical grade.

[0032] Weigh 9.0g of HSA in a beaker, add 50ml of 0.9% physiological saline, stir, dissolve, and form an HSA physiological saline solution for later use; Weigh 600.1mg of curcumin into a beaker, add 10ml of absolute ethanol, dissolve to make curcumin Absolute ethanol solution; dilute 25% glutaraldehyde solution to 2% glutaraldehyde solution. Place the HSA physiological saline solution in a constant temperature water bath at 30°C, while continuously stirring (480 rpm), add 10 ml of curcumin anhydrous ethanol solution to the HSA physiological saline solution, and continue to add 120 ml of anhydrous ethanol; add 2% pentanediol The a...

Embodiment 3

[0034] Reagents and materials: human serum albumin (Amresco distribution, biological reagent); 25% glutaraldehyde solution (Shanghai Chemical Reagent Purchasing and Supply Station, biochemical reagent); curcumin (provided by Shandong Target Drug Research Co., Ltd., purity determined by HPLC >99.0%). Other reagents are of domestic analytical grade.

[0035] Weigh 6.0g of HSA in a beaker, add 50ml of 0.9% physiological saline, stir, dissolve, and form an HSA physiological saline solution for later use; Weigh 400.5mg of curcumin into a beaker, add 10ml of absolute ethanol, dissolve to make curcumin Absolute ethanol solution; dilute 25% glutaraldehyde solution to 2% glutaraldehyde solution. Place the HSA physiological saline solution in a constant temperature water bath at 30°C, while continuously stirring (480 rpm), add 10 ml of curcumin anhydrous ethanol solution to the HSA physiological saline solution, and continue to add 120 ml of anhydrous ethanol; add 2% pentanediol The a...

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Abstract

The invention provides a pharmaceutical composition of curcumin and albumin nano particles, and a preparation method of the pharmaceutical composition. The albumin is made from human serum albumin or bovine serum albumin, or is prepared by taking ovalbumin as a raw material; and preferentially, the albumin is made from human serum albumin. The pharmaceutical composition prepared by the invention has better encapsulation rate.

Description

Field of Invention [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition of nano-particles made of curcumin and albumin, a preparation method and their use in the preparation of antitumor drugs. Background technique [0002] Curcumin (curcumin) is a polyphenolic compound extracted from the rhizomes of turmeric, curcuma, curcuma, etc. [0003] [0004] Pharmacological experiments have shown that curcumin has a variety of pharmacological effects, including anti-inflammatory, anti-cancer, antioxidant, kidney protection, inhibiting pulmonary fibrosis, inhibiting liver fibrosis, helping muscle damage repair, treating cataracts, anti-parasitic diseases, etc., especially In the aspect of tumor prevention and treatment, it may become a very promising drug candidate due to its remarkable curative effect, small toxic and side effects, and safe use [Yallapu MM, et al. Curcumin nanoformulations: a future nanomedicine for cancer...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/12A61K47/42A61P35/00A61P35/02
Inventor 刘珂郎跃武许卉
Owner CHANGZHOU TARGET MEDICINE TECH CO LTD
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