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Application of Forsythoside A in preparation of anti-influenza A H1N1 virus medicine and preparation thereof

A technology of forsythiaside and medicine, which is applied in the preparation of anti-influenza A (H1N1) virus drugs and its preparation field, and can solve problems that do not involve the application of forsythiaside in anti-influenza A (H1N1) virus drugs, etc.

Inactive Publication Date: 2013-04-24
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the prior art does not relate to the application of forsythiaside in the preparation of anti-H1N1 influenza virus drugs

Method used

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  • Application of Forsythoside A in preparation of anti-influenza A H1N1 virus medicine and preparation thereof
  • Application of Forsythoside A in preparation of anti-influenza A H1N1 virus medicine and preparation thereof
  • Application of Forsythoside A in preparation of anti-influenza A H1N1 virus medicine and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 In vivo pharmacodynamic test of forsythiaside in the treatment of respiratory virus infection

[0025] 1. Test purpose

[0026] To investigate the effectiveness of forsythoside in the treatment of respiratory virus infections, and to provide a basis for the research, development and clinical application of forsythoside.

[0027] 2. Test site

[0028] ABSL-2 Biosafety Laboratory, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences.

[0029] 3. Test materials

[0030] 3.1 Test drug

[0031] Forsythiaside, provided by Shanghai Yusen New Drug Development Co., Ltd., batch number: 090801, date of receipt: 2010.07.12, expiration date: tentatively 2 years; content: 94%, properties: light yellow powder, solubility: easily soluble in water , Storage conditions: sealed refrigerator at 4℃.

[0032] 3.2 Positive control drug

[0033] 3.2.1 Ribavirin injection: product of Tianjin Pharmaceutical Jiaozuo Co., Ltd., production date: 2009.11.07, batch number: 0911...

Embodiment 2

[0072] Example 2 In vitro anti-respiratory virus pharmacodynamic test of forsythiaside

[0073] 1. Test purpose

[0074] Observe the effect of forsythiaside against respiratory viruses in vitro.

[0075] 2. Test site

[0076] ABSL-2 Biosafety Laboratory, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences.

[0077] 3. Test materials

[0078] 3.1 Cells: Dog kidney cells (MDCK), human laryngeal carcinoma epithelial cells (Hep-2) and human cervical cancer cells (Hela) were purchased from the Cell Center of the Institute of Basic Medicine, Peking Union Medical College, and were routinely subcultured in our room.

[0079] 3.2 Viruses: A H1N1 influenza virus (PR8 strain, brisbane / 59 / 2007 strain), B influenza virus Jiangxi Xiushui strain, purchased from the influenza room of the Viral Disease Prevention and Control Institute of the Chinese Center for Disease Control and Prevention, and conventional chicken embryo passage in this room , TCID50 is 10 -4.5 , 10 -4 , 10 -...

Embodiment 3

[0124] Example 3 Preparation of freeze-dried powder injection

[0125] prescription:

[0126]

[0127] Preparation process: Take 50g of forsythiaside, 50g of glucose, and 150g of sorbitol, add 1000ml of water for injection, stir to dissolve, adjust pH to 5.0 with citric acid-disodium hydrogen phosphate buffer salt, and remove with 0.22μm microporous membrane Bacteria filtration, then use 8000 Dalton ultrafiltration membrane to remove pyrogen; after the intermediates are qualified, fill up the volume with water for injection, divide them into 1000 pieces, put them in a freezer, and freeze-dry according to the following freeze-drying curve.

[0128] Temperature(℃)

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PUM

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Abstract

Belonging to the field of traditional Chinese medicines, the invention discloses application of Forsythoside A in preparation of an anti-influenza A H1N1 virus medicine and a preparation thereof. In vivo pharmacodynamic experimental study on the Forsythoside A provided in the invention in treatment of respiratory virus infection and in vitro anti-respiratory virus pharmacodynamic experimental study on the Forsythoside A show that the Forsythoside A has an obvious inhibiting effect on influenza A H1N1 viruses.

Description

Technical field [0001] The present invention belongs to the field of traditional Chinese medicine. Specifically, the present invention relates to the use of forsythiaside in the preparation of anti-A H1N1 influenza virus drugs and preparations thereof. Background technique [0002] Forsythoside A is an effective ingredient extracted from Fructus Forsythiae, a plant of the genus Forsythia in the Oleaceae family. In the past, forsythin was used as an index to investigate the extraction process of forsythia. In recent years, with the in-depth research on the effective components of forsythia, it was found that forsythin has no antiviral activity. The content of forsythoside A is the highest in forsythoside, and almost all forsythoside A exerts antiviral effects. However, it is difficult for forsythoside A to exist independently. Therefore, it is customary to The active ingredient of forsythoside containing forsythoside A is called forsythoside. The structural formula of forsythias...

Claims

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Application Information

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IPC IPC(8): A61K31/7032A61P31/16
Inventor 赵志全苏瑞强李守信
Owner LUNAN PHARMA GROUP CORPORATION
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