Method for preparing anti-adhesive membrane for surgeries

An anti-adhesion film, surgical technology, applied in the direction of surgery, medical science, etc., to achieve the effect of stable structure, wide application range and no immunogenicity

Active Publication Date: 2013-04-24
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the long preparation time in the above anti-adhesion film cross-linking technology, the obtained cross-linked film has poor anti-adhesion effect, and the degradation speed may be fast or slow, which cannot meet the requirements To meet the clinical requirements, the present invention provides a method for preparing an anti-adhesion film for surgery with short cross-linking time, good anti-adhesion effect, moderate degradation rate, and suitable water absorption and breaking force.

Method used

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  • Method for preparing anti-adhesive membrane for surgeries
  • Method for preparing anti-adhesive membrane for surgeries
  • Method for preparing anti-adhesive membrane for surgeries

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Dissolve sodium hyaluronate with a molecular weight of 3000 kD and hydroxyethyl cellulose with a molecular weight of 90 kD in deionized water to prepare a solution with a concentration of 1.0% of sodium hyaluronate and hydroxyethyl cellulose, and use hydrogen The sodium oxide solution adjusts the pH value to 10 to obtain an alkaline solution;

[0029] (2) Add 1,4-butanediol diglycidyl ether to the alkaline solution, the mass ratio of it to solid matter is 1:20, stir evenly, and react at 25°C, 45°C, and 65°C respectively. The time is 2 hours;

[0030] (3) Add acetic acid to adjust the pH value of the solution to 2, stir well and evenly degas, pour it into a mold for casting, react at 25°C, 45°C, and 65°C respectively, and dry to form a film.

[0031] (4) The membrane was purified in deionized water for 8 h, and dried to constant weight at 37°C to obtain a double cross-linked sodium hyaluronate membrane.

[0032] The double-crosslinked film obtained by reacting at 2...

Embodiment 2

[0037] (1) Sodium hyaluronate with a molecular weight of 1700 kD and hydroxyethyl cellulose with a molecular weight of 200 kD were dissolved in deionized water to prepare a solution with a mass concentration of 1.0% of sodium hyaluronate and hydroxyethyl cellulose. Sodium hydroxide solution adjusts the pH value to 11 to obtain an alkaline solution;

[0038] (2) Add 1,4-butanediol diglycidyl ether to the alkaline solution, see Table 2 for the amount added, stir evenly, and react at 45°C for 2 hours;

[0039] (3) Add acetic acid to adjust the pH value of the solution to 4, stir well and evenly degas, pour it into a mold for casting, react at 45°C, and dry to form a film.

[0040](4) The membrane was purified in deionized water for 8 h, and dried to constant weight at 37°C to obtain a double cross-linked sodium hyaluronate membrane.

[0041] When the mass ratio of solids to crosslinking agent is 20:1, the obtained film has the best physical properties, with suitable water absorp...

Embodiment 3

[0046] (1) Sodium hyaluronate with a molecular weight of 1500 kD and hydroxyethyl cellulose with a molecular weight of 90 kD were dissolved in deionized water to prepare sodium hyaluronate with a mass concentration of 1.0% and hydroxyethyl cellulose with a mass concentration of 0.25% ~4.0% solution, use sodium hydroxide solution to adjust the pH value to 12 to obtain an alkaline solution;

[0047] (2) Add epoxy compound cross-linking agent 1,4-butanediol diglycidyl ether to the alkaline solution, the mass ratio of it to solid matter is 1:20, stir evenly, react at 45°C, and the reaction time is 2 hours;

[0048] (3) Add acetic acid to adjust the pH value of the solution to 3, stir well and evenly degas, pour it into a mold for casting, react at 45°C, and dry until a film is formed.

[0049] (4) The membrane was purified in deionized water for 10 h, and dried to constant weight at room temperature to obtain a double cross-linked sodium hyaluronate membrane.

[0050] With the i...

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Abstract

The invention relates to the technical field of the anti-adhesive membrane for surgeries, and in particular to a method for preparing an anti-adhesive membrane for surgeries. The method comprises the following steps of: dissolving sodium hyaluronate and hydroxyethyl cellulose or hydroxy propyl cellulose or carboxymethylcellulose in de-ionized water to form a solution, and adjusting the pH value to be 10-12, thereby obtaining an alkaline solution; adding 1,4-butanediol diglycidyl ether to the alkaline solution, stirring evenly, and reacting at 40-50 DEG C; adjusting the pH value of the reaction liquid to be 2-5, pouring the reaction liquid into a die for tape casting, reacting at 40-50 DEG C and drying, thereby forming the membrane. The method provided by the invention can be used for obviously improving the anti-adhesive effect, flexibility and film forming effect of the cross-linked membrane. The membrane obtained by the method provided by the invention has excellent biocompatibility, and good functions of resisting adhesion, stopping bleeding, promoting healing and resisting inflammation; and simultaneously, the membrane is appropriately adjustable in degradation time and wide in application range.

Description

technical field [0001] The invention relates to the technical field of anti-adhesion film for operation, in particular to a preparation method of anti-adhesion film for operation. Background technique [0002] In surgery, before suturing the wound, doctors generally place a layer of biofilm between the operated tissue and the organ to prevent the tissue from sticking to the organ. The film is biodegradable, remains in the patient's body for 7 to 10 days, then begins to break down, and will eventually be completely absorbed and disappear. [0003] Hyaluronic acid (Hyaluronic Acid, referred to as HA, also known as hyaluronic acid) is a natural substance widely present in humans and animals. It is a polymer composed of disaccharide units composed of glucuronic acid and acetylhexosamine. Mucopolysaccharide, no species difference, has good biocompatibility. At present, most of the anti-adhesion products with HA as the main material are natural HA, which are mainly solution or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/16
Inventor 郭学平刘建建冯晓毅石艳丽李超张燕耿凤
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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