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Method for preparing epoxidized fatty acid methyl ester through lipase catalysis

A technology of epoxy fatty acid methyl ester and fatty acid methyl ester, which is applied in the field of plasticizers, can solve the problems of harsh reaction conditions, toxic by-products, environmental pollution, etc., and achieve the effects of less by-products, high epoxy value, and environmental friendliness

Inactive Publication Date: 2013-05-08
闭美娥
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most chemical production is catalyzed by high-temperature acid and alkali, and there are problems such as toxic by-products, harsh reaction conditions, high energy consumption, and environmental pollution.

Method used

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  • Method for preparing epoxidized fatty acid methyl ester through lipase catalysis
  • Method for preparing epoxidized fatty acid methyl ester through lipase catalysis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Preparation of urea hydrogen peroxide

[0026] Start stirring with 25% hydrogen peroxide solution and 1.0g stabilizer EDTA. After it is completely dissolved, add urea. The molar ratio of hydrogen peroxide to urea is 1:1. Under constant stirring, heat up to 30°C. Completely dissolve urea, keep it warm for 20 minutes, cool to minus 5°C for crystallization, filter with suction, and dry at 50°C for 2 hours to obtain the urea peroxide product.

[0027] (2) Preparation of epoxy fatty acid methyl ester

[0028] Mix 100g of fatty acid methyl ester, 10g of formic acid and 3g of lipase Novozym435 evenly, stir and heat up to 30°C for reaction, then add urea hydrogen peroxide with a mass concentration of 25% in 3 times, each time adding 20g, react for 10h, and react The product is introduced into the separator, left to stand for stratification, and the upper organic phase is taken with Ca(OH) 2 Adjust the pH value to 6.5 and dry to obtain epoxy fatty acid methyl ester.

Embodiment 2

[0030] (1) Preparation of urea hydrogen peroxide

[0031] Start stirring with 30% hydrogen peroxide solution and 2.0g stabilizer EDTA. After it is completely dissolved, add urea. The molar ratio of hydrogen peroxide to urea is 1:1. Under constant stirring, heat up to 35°C. Completely dissolve urea, keep it warm for 30 minutes, cool to minus 5°C for crystallization, filter with suction, and dry at 50°C for 2 hours to obtain the urea peroxide product.

[0032] (2) Preparation of epoxy fatty acid methyl ester

[0033] Mix 100g of fatty acid methyl ester, 20g of formic acid and 4g of lipase Novozym435 evenly, stir and raise the temperature to 35°C for reaction, then add urea hydrogen peroxide with a mass concentration of 30% in 4 times, each time adding 15g, react for 9 hours, and react The product was introduced into a separator, allowed to stand for stratification, and the upper organic phase was taken to adjust the pH value to 7.0 with KOH, and dried to obtain epoxy fatty ...

Embodiment 3

[0035] (1) Preparation of urea hydrogen peroxide

[0036] Start stirring with 50% hydrogen peroxide solution and 2.0g stabilizer EDTA. After it is completely dissolved, add urea. The molar ratio of hydrogen peroxide to urea is 1:1. Under constant stirring, heat up to 35°C. Completely dissolve urea, keep it warm for 30 minutes, cool to minus 5°C for crystallization, filter with suction, and dry at 50°C for 2 hours to obtain the urea peroxide product.

[0037] (2) Preparation of epoxy fatty acid methyl ester

[0038] Mix 100g of fatty acid methyl ester, 30g of formic acid and 5g of lipase Novozym435 evenly, stir and heat up to 40°C for reaction, then add urea hydrogen peroxide with a mass concentration of 50% in 4 times, each time adding 10g, react for 8 hours, and then react The product was introduced into a separator, allowed to stand for stratification, and the upper organic phase was taken to adjust the pH value to 7.5 with NaOH, and dried to obtain epoxy fatty acid met...

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Abstract

The invention discloses a method for preparing epoxidized fatty acid methyl ester through lipase catalysis. The method comprises the following steps of mixing fatty acid methyl ester, organic acid and lipase uniformly according to a mass ratio of 100g:10-30g:3-5g, then adding 10-20g of urea hydrogen peroxide with mass concentration of 25-50% each time for 3-4 times, importing the reaction product into a separator after reacting for 8-10 hours, standing for layering, and drying to obtain the epoxidized fatty acid methyl ester. The method has the advantages of being mild in reaction conditions and environment-friendly, and the like.

Description

technical field [0001] The invention belongs to the field of plasticizers, in particular to a method for preparing epoxy fatty acid methyl ester by lipase catalysis. Background technique [0002] Vegetable oil-based plasticizers use natural vegetable oils to modify the structure of glycerides through functional group reactions to improve the compatibility between natural vegetable oils and PVC. The current research results in this area are mainly epoxidized grease. Epoxidized soybean oil is an epoxy plasticizer developed and applied earlier at home and abroad, and is widely used in the PVC industry. In recent years, the output has continued to grow, and the consumption of epoxy plasticizers has accounted for the largest amount of plasticizers. In the United States, its consumption is second only to phthalates and aliphatic dibasic esters, accounting for the second largest consumption three. Epoxidized soybean oil not only has a plasticizing effect on PVC, but also can qui...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P17/02
Inventor 闭美娥
Owner 闭美娥
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