A compound velvet antler polypeptide freeze-dried powder and nano-scale buffer microemulsion combined essence for skin beauty and health care and its preparation method

A technology of deer antler polypeptide, beauty and health care, applied in the field of combined essence, which can solve the problems of requiring special equipment, affecting product stability and actual effect, difficult industrial expansion test and large-scale production, etc.

Active Publication Date: 2014-10-22
海南巨鹿堂保健美容品有限公司 +1
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The shortcomings of the current application of beauty essence: the production of beauty essence is simple, easy to operate, convenient to use, and there are many advantages and advantages in practical application and its effect. However, there are many obvious defects and deficiencies in it.
The deficiencies in the application of beauty essence at present mainly include the following aspects: First, most essences used for skin beauty contain ethanol in different concentrations, which have certain olfactory irritation and skin irritation when used, especially some Ethanol-sensitive skin can easily cause skin allergies and dry skin, and it also has different degrees of irritation to the eyes; second, the role and efficacy of beauty essence mainly depend on the functional ingredients contained or added and their biological activity , but many functional ingredients and their biological activities are easily degraded or hydrolyzed in liquid or solvent, so that the molecular structure of many functional ingredients is destroyed, biological activity is lost, and physiological functions are reduced; third, the frequent opening of beauty essence is easy to volatilize and lose part of the solvent, which reduces the solubility and stability of the functional ingredients, which not only affects the sensory and quality of the product, but also affects the stability and actual effect of the product. Therefore, the essence is usually difficult to preserve and has a short storage period. Too long; fourth, if the beauty essence is not paid attention to hygiene during regular use, it is easy to cause pollution, breed a large number of harmful or pathogenic microorganisms, thereby affecting skin health, and even cause cross-infection; fifth, to promote Functional ingredients and biologically active substances are absorbed through the skin. Some beauty essences add a certain concentration of transdermal penetration-promoting agents, and some transdermal penetration-promoting agents are more likely to cause skin allergies or irritations, and excessive use may even have certain biological effects. Toxicity (such as DMSO, etc.); Sixth, most of the beauty essences are water-soluble substances, even if some oil-soluble substances are added, some emulsifiers or co-emulsifiers need to be added to make them evenly dispersed and completely dissolved, but It is also difficult to maintain the long-term stability of the essence even if some emulsifiers or co-emulsifiers are added, and some emulsifiers or co-emulsifiers have been used to cause skin allergies; The solvent itself does not have the effect of promoting the transdermal penetration and absorption of functional ingredients. Even if people artificially add some so-called skin penetration enhancers in the essence, their actual effect of promoting transdermal penetration is very limited, especially because of the skin barrier structure. The histological characteristics of the skin strictly restrict the passage of some exogenous substances, including proteins, water, sugar, lipids, vitamins, inorganic ions or cosmetic functional ingredients, and most functional ingredients cannot or are difficult to pass through the intact skin The stratum corneum barrier plays its due biological role, therefore, the functional ingredients and bioactive substances added to the serum have low bioavailability, limited biological role and use effect
[0011] The shortcomings of the current application of velvet polypeptide: velvet polypeptide has a wide range of biological effects and application fields as a biologically active functional ingredient, but velvet polypeptide is currently mainly u

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A compound velvet antler polypeptide freeze-dried powder and nano-scale buffer microemulsion combined essence for skin beauty and health care and its preparation method
  • A compound velvet antler polypeptide freeze-dried powder and nano-scale buffer microemulsion combined essence for skin beauty and health care and its preparation method
  • A compound velvet antler polypeptide freeze-dried powder and nano-scale buffer microemulsion combined essence for skin beauty and health care and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0087] Experimental Example 1: Transdermal penetration rate experiment of velvet antler polypeptide factor combination essence.

[0088] This experiment mainly studies the combined essence of velvet antler polypeptide factors (compound velvet antler polypeptide freeze-dried powder and nano-scale buffer microemulsion combined essence) and simple compound velvet antler polypeptide freeze-dried powder (with pH7.2 phosphate buffered saline (0.01mol / L ) dilution) to compare the transdermal filtration experiments of these two objects by Franz in vitro transdermal diffusion instrument. The results show that the combined essence of velvet antler polypeptide factor is higher than the cumulative transdermal absorption per unit area of ​​compound velvet polypeptide freeze-dried powder dissolved in phosphate buffered saline, which shows that the nano-scale buffer microemulsion is used as the essence matrix and solvent to prepare the essence. The combined essence can more effectively promo...

experiment example 2

[0089] Experimental example 2: Skin repair effect of velvet antler polypeptide factor combination essence:

[0090] 6 healthy rats, half male and half male, after 24 hours of skin preparation on the back of the rats, apply 50% glycolic acid gently and repeatedly on the depilatory area 2cm×2cm for 10 minutes, and absorb the excess liquid with a cotton ball, that is Skin exfoliation injury model. Then apply deer antler polypeptide factor combination essence on one side of the skin injury of the rat, and apply saline on the other side, twice a day for 15 consecutive days. Irritation and adverse reactions, and the moisture content of the damaged skin was detected at 15 days.

[0091] The experimental results show that applying velvet antler polypeptide after skin damage can significantly improve the peeled damaged skin of rats. After 15 days of application in this experiment, the scars on the administration side were significantly less than those on the control side, and the wate...

experiment example 3

[0092] Experimental Example 3: Clinical trial of velvet antler polypeptide factor combination essence:

[0093] Randomly recruited 30 healthy middle-aged and elderly volunteers who met the inclusion and exclusion criteria, all of whom were female, aged from 40 to 57 years old, with an average age of (48.12±5.45) years old, 26 of them were medical staff, 4 ordinary workers. According to the design of cosmetic medicine experiments and clinical observations, apply on the face twice a day, use 10 drops (about 0.5ml) each time, and use the combined essence prepared by natural velvet antler active polypeptide factor freeze-dried powder and activator (liquid) continuously Vegetarian, the use cycle is 4 weeks. In addition, before, during and after 4 weeks of aesthetic medicine and clinical trials, weekly follow-up visits were conducted and digital photos were taken. Then, the volunteers themselves and the researchers applied relevant evaluation scales and Photoshop CS5 software Cond...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the fields of cosmetic for skin beauty, health care, skin aging delay and the like, and particularly relates to combined essence of composite velvet antler polypeptide lyophilized powder and nano-scale buffering microemulsion for skin beauty and health care and a preparation method of the combined essence. The preparation method comprises the following steps of: extracting separated composite velvet antler polypeptide lyophilized powder with high efficiency and natural biological activity from fresh velvet antler, and preparing the combined beauty essence by using the composite velvet antler polypeptide lyophilized powder and nano-scale buffering microemulsion capable of prompting transdermal absorption of functional components at a ratio. Therefore, the combined essence provided by the invention has the advantages of fast transdermal absorption speed of the functional components, long biological activity storage period, high biological use degree, good action effect and safe utilization. Furthermore, the combined essence has a terse preparation process and simple technical operation; not only can the energy and the cost be saved, but also the low-carbon environmental friendliness can be achieved, and an environment is prevented from being polluted; and the combined essence provided by the invention is applicable to industrialized mass production, and popularization and application.

Description

technical field [0001] The invention relates to a combination essence which can be used for skin beauty and health care and skin aging delay and its preparation method. It is a compound velvet polypeptide freeze-dried powder extracted from fresh velvet, with natural biological activity velvet polypeptide and its protective agent as the main functional component, and nano-scale buffer microemulsion that can promote the transdermal absorption of functional components by a certain amount. The combined beauty essence formulated in proportion specifically relates to an essence combined with compound velvet antler polypeptide freeze-dried powder and nano-scale buffer microemulsion for skin beauty and health care and a preparation method thereof. Background technique [0002] 1. Technical background of beauty essence: [0003] Essence is the natural functional ingredients or bioactive substances or skin nutrients extracted, separated and purified from certain animal organs or tiss...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K8/64A61K8/86A61K8/06A61K8/02A61Q19/08A61Q19/00
Inventor 莫壮宏丁克祥左夏林朱晓亮郝林琳梁虹
Owner 海南巨鹿堂保健美容品有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products