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Method for transferring nano-particles from oil phase into aqueous phase

A nanoparticle, water phase technology, applied in separation methods, chemical instruments and methods, liquid displacement, etc., can solve the problem of difficult to remove oxidants, achieve excellent solubility and physiological compatibility, uniform size without change , the effect of simple process

Active Publication Date: 2014-12-10
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention overcomes the limitations of the existing ligand exchange method and amphiphile coating method that require the use of special or expensive water-soluble ligands and amphiphile polymer reagents, as well as the disadvantages of oxidizing oleic acid and difficult removal of oxidizing agents.

Method used

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  • Method for transferring nano-particles from oil phase into aqueous phase
  • Method for transferring nano-particles from oil phase into aqueous phase
  • Method for transferring nano-particles from oil phase into aqueous phase

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Monodisperse magnetic g-Fe coated with oleic acid 2 O 3 The nanoparticles were dispersed in a n-hexane solvent to obtain an oil-phase nanoparticles-n-hexane solution with a concentration of 9 mg / ml. Mix 25 ml of deionized water with 5 ml of absolute ethanol, and add 0.5 g of PVP to make an aqueous solution. Take 10 ml of the oil phase solution and mix the water phase solution and place it in a container with the oil phase solution in the upper layer and the water phase solution in the lower layer. Vigorously ultrasonically oscillate the mixed solution of the oil phase solution and the water phase solution for 45 minutes to obtain an oil-in-water microemulsion. The small amount of oil on the liquid surface of the microemulsion is oleic acid which is detached from the surface of the nanoparticles by ultrasonic vibration. Filter to remove a small amount of insoluble matter and oleic acid to obtain a uniform and stable microemulsion. The microemulsion can continue to be ev...

Embodiment 2

[0036] Monodisperse magnetic g-Fe coated with oleic acid 2 O 3 The nanoparticles were dispersed in a n-hexane solvent to obtain an oil-phase nanoparticles-n-hexane solution with a concentration of 9 mg / ml. Mix 25 ml of deionized water with 5 ml of absolute ethanol, and add 0.5 g of PVP to make an aqueous solution. Take 10 ml of the oil phase solution and mix the water phase solution and place it in a container with the oil phase solution in the upper layer and the water phase solution in the lower layer. Vigorously ultrasonically oscillate the mixed solution of the oil phase solution and the water phase solution for 45 minutes to obtain an oil-in-water microemulsion. The small amount of oil on the liquid surface of the microemulsion is oleic acid which is detached from the surface of the nanoparticles by ultrasonic vibration. Filter to remove a small amount of insoluble matter and oleic acid to obtain a uniform and stable microemulsion. The microemulsion can continue to be ev...

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Abstract

The invention provides a method for transferring nano-particles from an oil phase into an aqueous phase. The method includes the steps of mixing nano-particle solution dispersed in the non-polar oil phase with water, a stabilizer and cosurfactant solution, enabling the mixture to be subjected to ultrasonic emulsification and made into oil-in-water microemulsion, carrying out evaporation and drying on the microemulsion in a baking oven to obtain stabilizer-nano-particle composite dry jelly, adding polar solvent capable of dissolving the stabilizer into the dry jelly, slightly shaking so as to enable the dry jelly to be dissolved and dispersed into the solvent, and finally achieving the purpose of dispersion of the nano-particles transferred from the non-polar oil phase to the polar solvent. The method is simple in process, simple, convenient and quick in operation, and capable of effectively transferring the nano-particles dispersed in the oil phase to the aqueous phase.

Description

Technical field [0001] The invention belongs to the field of preparation, structural characterization, performance and application research of inorganic functional nanocomposite materials, and specifically relates to a method for transferring oil phase nanoparticles to water phase. Background technique [0002] Using the surface effect, volume effect, and optical or magnetic properties of nanoparticles, combined with the unique biological functions of biomolecules, they can be widely used in biology, medicine and other fields, such as drugs and gene carriers, nuclear magnetic resonance medical imaging and Cell separation. [0003] Magnetic nanoparticles are widely used in the field of biomedicine, but the requirements for magnetic nanoparticles are relatively high. Nanoparticles synthesized in the water phase often have defects in crystal structure or morphology. Nanoparticle materials prepared by hydrothermal synthesis and thermal decomposition have the advantages of high crysta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D12/00
Inventor 李达张志东姜菁菁李少杰耿殿禹龚文杰张强刘伟汪嘉恒
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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