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Alginic sodium diester enteric tablet and preparation method thereof

A technology of sodium alginate diester enteric and sodium alginate diester tablet, which can be applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve the instability of sodium alginate diester , carrying, inconvenient to use, unsatisfactory absorption effect, etc., to achieve the effect of ideal enteric coating effect, improving bioavailability, and stable product quality

Active Publication Date: 2014-08-20
CP PHARMA QINGDAO CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are mainly oral tablets, tablets, and injections of sodium alginate diester on the market in my country. Although oral tablets and tablets are convenient to take, they are affected by factors such as disintegration and drug release, and the absorption effect is not ideal. The bioavailability is low, and although the curative effect of the injection is fast, it is inconvenient to carry and use, and the sodium alginate diester is not stable in the aqueous solution

Method used

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  • Alginic sodium diester enteric tablet and preparation method thereof
  • Alginic sodium diester enteric tablet and preparation method thereof
  • Alginic sodium diester enteric tablet and preparation method thereof

Examples

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preparation example Construction

[0021] A preparation method of sodium alginate diester enteric-coated tablets, comprising the following steps:

[0022] (1) Take the sodium alginate diester according to the prescription, mix it evenly with the filler and disintegrant, use absolute ethanol as the binder, granulate with a 20-30 mesh sieve, dry it and press it into tablets to obtain the alginate diester sodium core;

[0023] (2) Dissolving enteric-coated material, plasticizer, anti-sticking agent and opacifying agent with 80% ethanol to make enteric-coating liquid;

[0024] (3) Evenly spray the prepared enteric coating solution on the surface of the diester sodium alginate tablet core prepared in step (1), and dry to obtain the diester sodium alginate enteric-coated tablet.

Embodiment 1～6

[0025] Preparation of Examples 1-6 Sodium Diester Alginate Enteric-coated Tablets

[0026] According to the raw and auxiliary materials in the following table, according to the above-mentioned preparation method, the enteric-coated tablets of sodium alginate diester of six examples were prepared. Among them, " / " means not used.

[0027]

[0028]

Embodiment 7～13

[0037] Preparation of Example 7-13 Sodium Diester Alginate Enteric-coated Tablets

[0038] According to the raw and auxiliary materials in the following table, according to the above-mentioned preparation method, enteric-coated tablets of sodium alginate diester were prepared for each example. The weight ratio of the shellac of Example 7 to cellulose acetate succinate is 4:1, the weight ratio of the shellac of Example 8 to cellulose acetate succinate is 3:1, the shellac of Example 9 and acetic acid succinate The weight ratio of cellulose is 2:1, the weight ratio of shellac and succinic cellulose acetate in Example 10 is 1:1, and the weight ratio of shellac and succinic cellulose acetate in Example 11 is 1:2, The weight ratio of shellac to cellulose acetate succinate in Example 12 was 1:3, and the weight ratio of shellac to cellulose acetate succinate in Example 13 was 1:4.

[0039]

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Abstract

The invention discloses an alginic sodium diester enteric tablet and a preparation method thereof. The alginic sodium diester enteric tablet disclosed by the invention consists of an alginic sodium diester tablet core and an enteric coating layer coated outside the alginic sodium diester tablet core, wherein the alginic sodium diester tablet core comprises alginic sodium diester, filler and a disintegrant, and the enteric coating layer comprises an enteric material, a plasticizer, an antisticking agent and an opacifier; and during preparation, the alginic sodium diester enteric tablet is prepared through coating the enteric coating layer outside the alginic sodium diester tablet core. According the alginic sodium diester enteric tablet and the preparation method of the alginic sodium diester enteric tablet, the enteric effect is ideal, the bioavailability can be improved, and the stimulation to gastric mucosa caused by the drug is reduced; and the preparation method is simple, the quality of obtained products is stable, and thus, the method is applicable to large-scale production application.

Description

technical field [0001] The invention relates to the technical field of western medicine preparations, in particular to a diester sodium alginate enteric-coated tablet, and the invention also relates to a preparation method of the enteric-coated tablet. Background technique [0002] Alginic Sodium Diester is a polysaccharide sulfate (PSS) marine drug. It is made from alginic acid extracted from kelp and sargassum through hydrolysis, esterification and sulfonation. Sodium alginate has heparan-like physiological activity, can reduce blood viscosity, has anticoagulant and antithrombotic, blood viscosity lowering and peripheral vasodilation effects, and is mainly used for ischemic cerebrovascular diseases such as cerebral thrombosis, Cerebral embolism, cerebral arteriosclerosis, stroke, hyperlipidemia, coronary heart disease, hyperviscosity syndrome and other transient ischemic attacks, prevention and treatment of coronary heart disease and angina pectoris. In recent years, wit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/36A61K9/34A61K31/737A61K47/38A61P9/10A61P3/06A61P3/10A61P13/12A61P1/16A61P17/10A61P27/16A61P7/02
Inventor 王明刚任莉陈阳生
Owner CP PHARMA QINGDAO CO LTD
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