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Sodium nitroprusside synthesis process

A synthesis process, the technology of sodium nitroprusside, which is applied in the direction of ferricyanide, metal cyanide, etc., can solve the problems such as the synthesis process of sodium nitroprusside that has not been found, and achieve the effect of high product purity, less magazines, and less investment in equipment and sites

Inactive Publication Date: 2013-06-19
KAMP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no related synthesis process of sodium nitroprusside

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Add 100g of potassium nitroferricyanide to a 5000ml reaction flask, add 2000ml of purified water and raise the temperature to 70°C to fully dissolve. Another 80g of copper sulfate pentahydrate was dissolved in 200ml of purified water, and slowly added dropwise to the potassium nitroferricyanide solution after the dissolution was complete. The dropwise addition time was 30 minutes, and the temperature was kept for 20 minutes after the dropwise addition was completed. The filter cake was collected by centrifugation at 40°C and placed in a reaction vial. At the same time, 50 g of sodium bicarbonate was weighed, prepared into a saturated aqueous solution, and added dropwise to the reaction bottle. After the dropwise addition was completed in 30 minutes, centrifuged to collect the filtrate and washing liquid. After mixing the filtrate and washing liquid, stir and add 4--6ml glacial acetic acid dropwise until no bubbles are generated. Add the filtrate and washing liquid mix...

Embodiment 2

[0020] Add 100g of potassium nitroferricyanide to a 5000ml reaction flask, add 2000ml of purified water and raise the temperature to 70°C to fully dissolve. Another 80g of copper sulfate pentahydrate was dissolved in 200ml of purified water, and slowly added dropwise to the potassium nitroferricyanide solution after the dissolution was complete. The dropwise addition time was 20 minutes, and the temperature was kept for 20 minutes after the dropwise addition was completed. The filter cake was collected by centrifugation at 40°C and placed in a reaction vial. At the same time, 50 g of sodium bicarbonate was weighed, prepared into a saturated aqueous solution, and added dropwise to the reaction flask. After the addition was completed in 20 minutes, centrifuged to collect the filtrate and washing liquid. After mixing the filtrate and washing liquid, stir and add 4--6ml glacial acetic acid dropwise until no bubbles are generated. Add the filtrate and washing liquid mixture to a ...

Embodiment 3

[0022] Add 100g potassium nitroferricyanide to a 5000ml reaction bottle, add 2000ml purified water and raise the temperature to 80°C to fully dissolve. Another 80g of copper sulfate pentahydrate was dissolved in 200ml of purified water, and slowly added dropwise to the potassium nitroferricyanide solution after the dissolution was complete. The dropwise addition time was 40 minutes, and the temperature was kept for 20 minutes after the dropwise addition was completed. The filter cake was collected by centrifugation at 40°C and placed in a reaction vial. At the same time, 50 g of sodium bicarbonate was weighed, prepared into a saturated aqueous solution, and added dropwise to the reaction flask. After the dropwise addition was completed in 35 minutes, centrifuged to collect the filtrate and washing liquid. After mixing the filtrate and washing liquid, stir and add 4--6ml glacial acetic acid dropwise until no bubbles are generated. Add the filtrate and washing liquid mixture t...

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PUM

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Abstract

The invention relates to a sodium nitroprusside synthesis processes, wherein potassium nitroprusside and copper sulfate pentahydrate are adopted as reaction raw materials and are subjected to a reaction under a suitable reaction condition to generate copper nitroprusside, the copper nitroprusside reacts with sodium bicarbonate to generate sodium nitroprusside, and concentration crystallization, centrifugation and vacuum drying are performed after the complete reaction to obtain the product. The synthesis process has characteristics of simpleness, easy operation, high product purity, and high yield, and is suitable for industrial production.

Description

technical field [0001] The invention relates to a synthesis process of raw materials, which is a synthesis process of sodium nitroprusside with fewer steps, high yield and high purity. Background technique [0002] Sodium nitroprusside is a fast-acting and short-acting vasodilator. It has a direct expansion effect on both arterial and venous smooth muscle, but does not affect the contraction of the uterus, duodenum or myocardium; it does not change much the local blood flow distribution. Vasodilation reduces peripheral vascular resistance, thus lowering blood pressure. Vasodilation reduces the preload and afterload of the heart and improves cardiac output, so it is beneficial to heart failure. Afterload reduction reduces valvular insufficiency by reducing aortic and left ventricular impedance and reducing regurgitation. Immediately after intravenous infusion, the peak plasma concentration is reached, and its level depends on the dose. This product is metabolized into cya...

Claims

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Application Information

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IPC IPC(8): C01C3/12
Inventor 朱敏贺莲张静陈锋吴锋陈敏杨述
Owner KAMP PHARMA
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