Sodium cantharidinate and vitamin B6 dropping pills and preparation method thereof

A technology of sodium cantharidate and vitamins, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of limited dosage form and single, and achieve the effects of reducing adverse reactions, reducing burden, and increasing compliance.

Active Publication Date: 2013-07-10
GUIZHOU BAIQIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a sodium cantharidate vitamin B6 drop pill with convenient ta

Method used

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  • Sodium cantharidinate and vitamin B6 dropping pills and preparation method thereof
  • Sodium cantharidinate and vitamin B6 dropping pills and preparation method thereof
  • Sodium cantharidinate and vitamin B6 dropping pills and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1, through process research, finally formulate production process such as:

[0050] (1) Prescription

[0051] Sodium Cantharidinate 0.1g

[0052] Vitamin B6 2.5g

[0053] Polyethylene glycol 6000 18.6g

[0054] Ethylene oxide monostearyl S-40 4.5g

[0055] Poloxamer 4.5g

[0056] Makes 1000 pills

[0057] (2) Method

[0058]Take polyethylene glycol 6000, ethylene oxide monostearyl S-40 and poloxamer according to the prescription, add sodium cantharidate raw material fine powder and vitamin B6 raw material fine powder, mix well, heat to 80-90 ° C, wait After all melted, mechanically stir at high speed for 10 minutes until uniform, transfer to the liquid storage bottle, keep warm at 80-90°C, drop into simethicone at 20-30°C, drop distance 3-6cm, drop speed 40-50 drops / min , drain the formed dripping pills, wipe off the simethicone, coat them, and make 1000 pills.

[0059] (3) Research on coating process

[0060] 1. Research on the composition of the co...

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PUM

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Abstract

The invention discloses sodium cantharidinate and vitamin B6 dropping pills. The sodium cantharidinate and vitamin B6 dropping pills comprise the following raw materials in parts by weight: 0.1 part of sodium cantharidinate, 2.5 parts of vitamin B6, 18.6 parts of polyethylene glycol 6000, 4.5 parts of epoxy vinyl monostearate S-40 and 4.5 parts of poloxamer. A preparation method of the sodium cantharidinate and vitamin B6 dropping pills comprises the following steps of: taking the polyethylene glycol 6000, the epoxy vinyl monostearate S-40 and the poloxamer according to a formula, adding fine powder of the sodium cantharidinate raw material and the fine powder of the vitamin B6 raw material, uniformly mixing, heating to 80-90 DEG C, performing mechanical high-speed stirring for 10min till uniformity after all raw materials are molten, transferring into a liquid storage bottle, performing heat preservation at the temperature of 80-90 DEG C, and dropping into dimethyl silicon oil at the temperature of 20-30 DEG C, wherein the dropping distance is 3-6cm, and the dropping speed is 40-50 drops/min; and completely draining the formed dropping pills and erasing dimethyl silicon oil coatings to prepare the pills. According to the sodium cantharidinate and vitamin B6 dropping pills disclosed by the invention, the insufficiency of the single existing limited formulation is overcome.

Description

Technical field [0001] The present invention involves a sodium sodium pill and its preparation method, which belongs to the field of dripping pill preparation preparation. Background technique [0002] The existing sodium sodium vitamin B6 injection is an antitumor injection from sodium sodium and vitamin B6.Its pharmacological effects are as follows: inhibit the synthesis of protein and nucleic acids of tumor cells, and then affect the biological synthesis of RNA and DNA, and ultimately inhibit the production and division of cancer cells; reduce the activity of CAMP phosphate in tumor cells and increase the vitalityImproving cell energy metabolism while reducing the level of cancer toxins; it can directly inhibit the synthesis of DNA and RNA in the cancer cells and the infiltration of the forefront, change the shape and function of the cancer cells, and directly kill the cancer cells.There is no inhibitory effect on bone marrow cells and can increase white blood cells. [0003] ...

Claims

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Application Information

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IPC IPC(8): A61K31/4415A61K9/42A61K47/44A61P35/00A61K31/34
Inventor 张云辉岑春
Owner GUIZHOU BAIQIANG PHARMA
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