Organic/inorganic composite three-dimensional porous scaffold with drug sustained release function, and preparation method thereof

A three-dimensional porous, inorganic composite technology, applied in medical science, surgery, etc., can solve the problems of drug release regulation that is difficult to control, lack of highly penetrating pores, organic/inorganic composite scaffolds, etc.

Active Publication Date: 2013-07-10
广州雄俊智能科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of bioceramic stents (such as hydroxyapatite (HA), β-tricalcium phosphate (β-TCP)) for local drug sustained release is that because such stents generally adopt the traditional impregnation method to load drugs on On the stent, it is difficult to control the drug release pattern
[0007] In summary, there is a lack of research in the field on organic / inorganic composite scaffolds with highly ordered porous structures, highly permeable channels, and capable of local drug delivery to bone repair sites for a long time

Method used

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  • Organic/inorganic composite three-dimensional porous scaffold with drug sustained release function, and preparation method thereof
  • Organic/inorganic composite three-dimensional porous scaffold with drug sustained release function, and preparation method thereof
  • Organic/inorganic composite three-dimensional porous scaffold with drug sustained release function, and preparation method thereof

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preparation example Construction

[0070] The invention relates to an organic / inorganic composite three-dimensional porous support with drug sustained release and a preparation method thereof. With the help of MAM (Motor Assisted Microsyringe, motor-assisted microinjector) free forming technology, under the control of the computer, the inorganic / organic / drug composite materials with certain fluidity in the extrusion cavity are extruded through the nozzle and superimposed on the working surface layer by layer. On the stage, a three-dimensional porous scaffold is formed. The preparation process of the present invention is simple and easy, low in cost, high in efficiency, and does not need to be post-processed on the scaffold, and is controlled by a computer. The prepared three-dimensional porous composite scaffold containing medicine is suitable for loading and slow release of medicine, and has great advantages in the field of bone tissue engineering. Broad application prospects.

[0071] In the present inventio...

Embodiment approach

[0154] The purpose of the present invention is to propose a new type of organic / inorganic composite three-dimensional porous scaffold based on MAM free-forming technology, which has drug sustained release and uses fat-soluble polymer as the organic phase, and its preparation method. A method of gradient volatilization of solvents is proposed to completely remove the organic solvents used in the material compounding process, which can effectively avoid the problems of inorganic powder settlement and agglomeration that may occur during the solvent volatilization process, and lay the foundation for the formation of subsequent scaffolds . In addition, the mechanical properties, degradability, drug release and antibacterial properties of the scaffold can be adjusted by changing the relative ratio of the scaffold components while ensuring the requirements of the scaffold for pore size, porosity, and pore permeability.

[0155] The method for preparing the organic / inorganic composite...

Embodiment 1

[0184] (1) Synthesis of β-tricalcium phosphate (β-TCP) powder:

[0185] (a) Weigh 115.42g Ca(NO 3 ) 2 4H 2 O in a 2L beaker, add 967.74ml of deionized water, and adjust the pH at 8.2±0.1[Ca] with ammonia water;

[0186] (b) Weigh 43.03g (NH 4 ) 2 HPO 4 In a 3L beaker, add 645.16mL of deionized water, and adjust the pH at 8.2±0.1[P] with ammonia water;

[0187] (c) Put the Ca solution in a 250mL separatory funnel, slowly drop it into the P solution (you can directly drop it with a dropper), and use ammonia water to maintain the pH of the solution at 8.2±0.1;

[0188] (d) Stir the mixed solution for 24 hours, filter the precipitated deionized water three times, wash with alcohol once;

[0189] (e) Drying at 100°C to remove water;

[0190] (f) Sinter at 850°C, hold for 2 hours, and heat up at a rate of 4°C / min.

[0191] The obtained powder is passed through a 200-mesh sieve for subsequent use.

[0192] (2) Preparation of polylactic acid / β-tricalcium phosphate / ibuprofen ...

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Abstract

The invention provides a preparation method of organic / inorganic composite three-dimensional porous scaffold with drug sustained release function. The method comprises the following steps of: (1) preparing organic / inorganic / drug composite material; and (2) putting the organic / inorganic / drug composite material obtained in the step (1) into an extrusion cavity of a motor assisted microsyringe (MAM) free-forming device to form the organic / inorganic composite three-dimensional porous scaffold with drug sustained release function.

Description

technical field [0001] The invention relates to an organic / inorganic composite three-dimensional porous scaffold with drug sustained release and a preparation method thereof, belonging to the field of bone tissue engineering scaffold and drug sustained release. Background technique [0002] Developing suitable scaffold materials to treat bone defects has always been a hot topic in bone tissue engineering research. As one of the key elements of bone tissue engineering, an ideal three-dimensional scaffold requires a suitable pore size, high porosity, and a highly connected pore structure to facilitate the exchange of oxygen, nutrients, and metabolites, and to facilitate the mass planting of cells. and proliferation, secretion of extracellular matrix, and ingrowth of blood vessels and nerves provide space and environment. [0003] When implanting bone tissue engineering scaffold materials into defect sites, the primary problem is the risk of inflammation and even complications...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16A61L31/06A61L31/02
Inventor 宁聪琴袁萍
Owner 广州雄俊智能科技有限公司
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