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Multi-level composite microsphere with temperature sensibility and preparation method thereof

A composite microsphere and sensitive technology, applied in the field of multi-level composite microsphere and its preparation, can solve the problems of lack of environmental responsiveness and achieve the effect of simple method

Active Publication Date: 2013-07-10
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This kind of composite microspheres can encapsulate and release drugs, and the drug loading efficiency can be achieved by controlling the size of the microspheres and other factors, but it also lacks environmental responsiveness.
[0005] At present, there is no report on the secondary assembly of poly(isopropylacrylamide-styrene) spheres at the oil-water interface to form pH-sensitive multi-level composite microspheres.

Method used

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  • Multi-level composite microsphere with temperature sensibility and preparation method thereof
  • Multi-level composite microsphere with temperature sensibility and preparation method thereof
  • Multi-level composite microsphere with temperature sensibility and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Preparation of poly(isopropylacrylamide-styrene) pellets

[0022] Dissolve 1g of isopropylacrylamide and 1g of styrene monomer in 40mL of deionized water, pass nitrogen gas, stir magnetically for 2 hours, add 0.01g of azobisisobutyronitrile, heat up to 60°C and react for 24 hours to obtain poly(isobutyronitrile) Propylacrylamide-styrene) emulsion. The particle size d measured by dynamic light scattering is 130 nm.

[0023] (2) Preparation of temperature-sensitive multi-level composite microspheres

[0024] Take 1mL poly(isopropylacrylamide-styrene) emulsion solution and 10mL formamide / ethanol solution (the content of formamide is 20wt%), put it in an ice-water bath, slowly add 20mL toluene and stir for 3 hours to obtain a temperature-sensitive multi-level composite microspheres.

[0025] (3) Temperature sensitivity test

[0026] The particle size of the temperature-sensitive multi-stage composite microsphere emulsion obtained in (2) was measured by dynamic light...

Embodiment 2～4

[0028] The process is the same as in Example 1, but the feeding amount of isopropylacrylamide in (1) is changed to 0.5g, 1.5g, and 2g respectively. The experimental results are shown in Table 1.

Embodiment 5～7

[0030] The process is the same as in Example 1, but the content of formamide in (2) is changed to 5wt%, 10wt%, and 30% respectively. The experimental results are shown in Table 2.

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Abstract

The invention discloses a multi-level composite microsphere with temperature sensibility and a preparation method thereof, and relates to a response stimulation type composite material and a preparation method thereof. The preparation method comprises steps of: firstly, adopting a soap-free emulsion method to prepare poly (isopropyl acrylamide-styrene) spheres; and secondly, based on the polarity difference between a water interface and an oil interface and the interaction among the poly (isopropyl acrylamide-styrene) spheres, carrying out secondary assembly to obtain the multi-level composite microsphere with temperature sensibility. The composite microsphere is assembled of a plurality of nano spheres and can be disassembled when reaching a mutation temperature, and the mutation temperature can be controlled through adjusting the ratio of isopropyl acrylamide to styrene, so that the microsphere has an extremely high application value.

Description

technical field [0001] The invention belongs to the field of material technology and self-assembly, and specifically relates to a temperature-sensitive multi-level composite microsphere and a preparation method thereof, in particular to a poly(isopropylacrylamide-styrene) microsphere A multilevel composite microsphere formed by secondary assembly of units at the water-oil interface and a preparation method thereof. Background technique [0002] Stimuli-responsive polymers refer to a class of polymers that can respond to subtle stimuli in the external environment (including temperature, pH, ionic strength, sound, electricity, light, magnetism, etc.). Widely used in sensors, smart switches, drug carriers, selective catalysis, memory materials and other fields. [0003] Self-assembly technology is the use of spontaneous mutual recognition between basic structural units to form aggregates with a specific arrangement order through non-covalent weak interaction forces (such as hy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02C08F220/54C08F212/08C08F2/22
Inventor 戴李宗陈凌南曾碧榕叶华立李聪陈国荣许一婷罗伟昂
Owner XIAMEN UNIV
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