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Liquid crystal structure contained solid lipid nanoparticle and preparation method thereof

A technology of solid lipid nanometer and liquid crystal structure, which is applied in the direction of pharmaceutical formulations, cosmetic preparations, dressing preparations, etc., can solve the problems that solid lipid nanoparticles containing liquid crystal structure have not been reported, and achieve simple preparation process and high energy efficiency. The effect of low consumption

Active Publication Date: 2015-01-07
广东三好科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many researches on the preparation technology of solid lipid particles. There was a scientific paper on the technical research of solid lipid particles containing liquid crystal structure, but the particle size is above 1 μm, while the research on solid lipid nanoparticles containing liquid crystal structure has not yet been seen. to report

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  • Liquid crystal structure contained solid lipid nanoparticle and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A solid lipid nanoparticle containing a liquid crystal structure, calculated by weight percentage, its raw material composition and content are as follows:

[0034] Fatty alcohol oil 1%

[0035] Non-fatty alcohol oil 0.5%

[0036] Emulsifier 1%

[0037] Organic additives 1%

[0038] Inorganic additives 0.01%

[0039] Water 96.49%

[0040] The fatty alcohol oils are cetyl alcohol and octadecyl alcohol calculated by mass ratio, that is, cetyl alcohol: octadecyl alcohol is a mixed alcohol composed of 1:3, an industrial product produced by BASF (China) Chemical Co., Ltd. grade products;

[0041] The non-fatty alcohol oil is octadecanoic acid, an industrial-grade product produced by Kerry Cereals and Oils (China) Chemical Co., Ltd.;

[0042] The emulsifier is fatty alcohol polyoxyethylene ether, namely fatty alcohol polyoxyethylene ether (21EO), an industrial grade product provided by Croda (China) Co., Ltd.;

[0043] Described inorganic additive is sodium chloride, t...

Embodiment 2

[0052] A solid lipid nanoparticle containing a liquid crystal structure, calculated by weight percentage, its raw material composition and content are as follows:

[0053] Fatty alcohol oil 10%

[0054] Non-alcoholic fats and oils 4%

[0055] Emulsifier 5%

[0056] Organic additives 12%

[0057] Inorganic additives 1%

[0058] water 68%

[0059] Described fatty alcohol grease is cetyl alcohol, the industrial grade product that BASF (China) Chemical Co., Ltd. produces;

[0060]The non-fatty alcohol oil is myristic acid, an industrial-grade product produced by Kerry Grain and Oil (China) Chemical Co., Ltd.;

[0061] The emulsifier is a mixture of hexadecyl glucoside and octadecyl glucoside calculated by mass ratio, that is, hexadecyl glucoside: octadecyl glucoside at a ratio of 1:3. Sepic (China) Chemical Co., Ltd. Industrial-grade products provided by the company;

[0062] Described inorganic additive is sodium chloride, the chemically pure product of Sinopharm Chemical ...

Embodiment 3

[0070] A method for preparing solid lipid nanoparticles containing a liquid crystal structure, calculated by weight percentage, the raw material composition and content are as follows:

[0071] Fatty alcohol oil 20%

[0072] Non-fatty alcohol oil 8%

[0073] Emulsifier 10%

[0074] Organic additives 25%

[0075] Inorganic additives 2.0%

[0076] water 35%

[0077] The fatty alcohol oil is stearyl alcohol, an industrial grade product produced by BASF (China) Chemical Co., Ltd.;

[0078] The non-fatty alcohol oil is caprylic capric triglyceride, an industrial grade product produced by BASF (China) Chemical Co., Ltd.;

[0079] The emulsifier is a mixture of hexadecyl glucoside and octadecyl glucoside calculated by mass ratio, that is, hexadecyl glucoside: octadecyl glucoside at a ratio of 1:3. Cypic (China) Chemical Co., Ltd. Provided industrial grade products;

[0080] Described inorganic additive is sodium chloride, the chemically pure product of Sinopharm Chemical Reage...

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Abstract

The invention discloses a liquid crystal structure contained solid lipid nanoparticle and a preparation method thereof. The liquid crystal structure contained solid lipid nanoparticle is composed of, by mass, 1-20% of fatty alcohol class grease, 0.5-8% of non-fatty alcohol class grease, 1-10% of emulsifier, 1-25 of organic additive, 0.01-2.0% of inorganic additive and the balance water. The method includes: heating oil-phase components formed by fatty alcohol class grease, non-fatty alcohol class grease and emulsifier to 70-90 DEG C to obtain evenly dispersed oil-phase components; and heating aqueous-phase components formed by organic additive, inorganic additive and water to 70-90 DEG C to obtain evenly dispersed aqueous-phase components, homogeneously mixing the oil-phase components and the aqueous-phase components and cooling to room temperature, and finally obtaining the liquid crystal structure contained solid lipid nanoparticle with the grain size of 300-800nm.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and relates to a liquid crystal structure-containing solid lipid nanoparticle and a preparation method thereof. Background technique [0002] Solid lipid nanoparticles (SLN) are solid lipids with high melting point and good biocompatibility, such as saturated fatty acid esters, fatty acids, fatty alcohols, mixed esters, one or several mixtures of them as carrier materials, and The emulsifier is stable in dispersion and forms a new drug slow-release carrier. It is mainly suitable for the coating of lipophilic active components. It can also be coated with hydrophilic substances after forming a water-in-oil system first. SLN can effectively control the release of active components; the carrier material has good biocompatibility. It can realize the coating of skin irritating substances and improve the safety of application. [0003] Liquid crystal is a thermodynamically stable phase state between...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/02A61K8/92A61K8/86A61K8/34A61K8/19A61K9/14A61K47/44A61K47/34A61K47/10A61K47/02
Inventor 张婉萍李想李琼刘晓慧
Owner 广东三好科技有限公司