Pharmaceutical composition containing metronidazole

Abstract

The invention relates to a pharmaceutical composition containing metronidazole and particularly relates to a pharmaceutical composition. The pharmaceutical composition contains metronidazole, clotrimazole, chlorhexidine acetate, sodium carboxymethyl starch, sodium carboxymethylcellulose, glycerine and water. The pharmaceutical composition disclosed by the invention has favorable pharmaceutical properties.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition in paste form, in particular to a pharmaceutical composition containing metronidazole, clotrimazole and chlorhexidine acetate. It can be called Shuangzotai ointment. Background technique [0002] Vaginitis is an inflammation of the vaginal mucosa and submucosal connective tissue. Clinically, vaginitis is characterized by changes in the characteristics of leucorrhea and vulvar itching and burning pain. Pain during sexual intercourse is also common. When the infection involves the urethra, there may be dysuria and urgency. Symptoms such as the disease bring great distress to the life and work of the patient. Common vaginitis includes bacterial vaginosis, trichomonas vaginitis, fungal vaginitis, and senile vaginitis. [0003] Bacterial vaginosis is a mixed infection dominated by Gardnerella, various anaerobic bacteria, and Campylovibrio. Fungal vaginit...

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Problems solved by technology

These medicaments that this area uses all are to treat vaginitis, and vaginitis is divided into many kinds: trichomonas vaginitis, bacterial vaginitis, mycotic vaginitis, mixed vaginitis etc., these inflammations again with mixed vaginitis Vaginitis is the most difficult to eradicate, and the recurrence rate is extremely high. The use effect of these dosage forms shows that Shuangzotai has a poor therapeutic effect on mixed vaginitis. According to the analysis of the feedback from the use, the main reason is that effervescent tablets need to absorb water It can disintegrate, and there is a burning sensation for patients with vaginal dryness; suppositories need to be melted by body temperature, and the onset of action is slow; and the disintegration or melting of suppositories and effervescent tablets has a short residence time, and the drug absorption effect is poor, so it is not suitable for repeated attacks. The curative effect of vaginitis is not good; the ointment is an oily base, which affects the normal function of the skin and mucous membrane, and the contact surface with the mucous membrane is small, and the effective residence time in the vagina is short, thus affecting the curative effect

[0009] Many existing bizoate preparations are solid preparations or oil-based preparations, such as vaginal effervescent tablets, vaginal suppositories, etc. Vaginal effervescent tablets are prone to discomfort to patients due to their dry surface , and the suppository made with lipophilic matrix is ​​easy to stain clothing and will also cause discomfort to patients, so it is urgently expected by those skilled in the art to make bisazole preparations such as ointment preparations with hydrophilic matrix for clinical use

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