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Preparation method of monodisperse rosinyl polymer microsphere

A polymer microsphere and rosin-based technology, which is applied in the field of preparation of monodisperse rosin-based polymer microspheres, can solve the problems of long cycle, cumbersome preparation steps, and difficult control, and achieve easy operation, simple process, and uniform particle size Effect

Active Publication Date: 2013-07-24
GUANGXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In terms of polymer microsphere preparation technology, the traditional emulsion polymerization method can only prepare polymer microspheres with a particle size of less than 1.0 μm, while the particle size of the polymer microspheres prepared by the suspension polymerization method is between 100 and 1000 μm, and the particle size is less than 1.0 μm. The diameter distribution is wide; the seed emulsion polymerization method can prepare monodisperse polymer microspheres with a particle size of 1.0-100 μm, but the preparation steps are cumbersome, difficult to control, and the cycle is long

Method used

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  • Preparation method of monodisperse rosinyl polymer microsphere

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Effect test

Embodiment 1

[0016] Add 0.5 g dehydroabietic acid (2-acryloyloxyethyl) ester, 25 mL isopropanol / water (20:5), 0.2 g polyvinylpyrrolidone, 0.001 g azobisiso Butyronitrile, stir to dissolve and mix evenly, and then pass nitrogen gas for 20 minutes to remove oxygen. Stir mechanically at 60°C, and react to obtain a milky white suspension. Settling by centrifugation in an ultracentrifuge, pouring out the supernatant, ultrasonic cleaning, repeated operations four times, drying the cleaned microspheres to constant weight, and obtaining white powdery monodisperse rosin-based polymer microspheres.

Embodiment 2

[0018] Add 0.8 g dehydroabietic acid (2-acryloyloxyethyl) ester, 25 mL isopropanol / water (20:5), 0.2 g polyvinylpyrrolidone, 0.003 g azobisiso Butyronitrile, stir to dissolve and mix evenly, and then pass nitrogen gas for 20 minutes to remove oxygen. Stir mechanically at 60°C. After about 1.5 hours of reaction, the system begins to appear white turbidity, and finally turns into a milky white suspension. Settling by centrifugation in an ultracentrifuge, pouring out the supernatant, ultrasonic cleaning, repeated operations four times, drying the cleaned microspheres to constant weight, and obtaining white powdery monodisperse rosin-based polymer microspheres.

Embodiment 3

[0020] Add 0.5 g of dehydroabietic acid (2-acryloyloxyethyl) ester, 25 mL of isopropanol / water (20:5), 0.2 g of polyvinylpyrrolidone, 0.003 g of azobisiso Butyronitrile, stir to dissolve and mix evenly, and then pass nitrogen gas for 20 minutes to remove oxygen. Stir mechanically at 50°C, the reaction proceeds for about 1.5h, and the system begins to appear white turbidity, and finally turns into a milky white suspension. Settling by centrifugation in an ultracentrifuge, pouring out the supernatant, ultrasonic cleaning, repeated operations four times, drying the cleaned microspheres to constant weight, and obtaining white powdery monodisperse rosin-based polymer microspheres.

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Abstract

The invention discloses a preparation method of monodisperse rosinyl polymer microspheres. The monodisperse rosinyl polymer microspheres are obtained by taking rosin acrylics as monomers and adopting a conventional radical inhibitor and a dispersing agent in a mixed solution of alcohol and water through dispersion copolymerization. The preparation method is simple in process and easy to operate; and the prepared monodisperse rosinyl polymer microspheres are uniform in particle size and are controllable in the range from 0.8 microns to 3.0 microns. Due to adoption of the preparation method, rosins are endowed with wide applications, and the obtained polymer microspheres have good application prospect in the aspect of drug sustained release.

Description

technical field [0001] The invention belongs to the field of polymer material preparation, in particular to a method for preparing monodisperse rosin-based polymer microspheres. Background technique [0002] Rosin is a renewable natural resource whose main component is resin acid. There are two chemical reaction centers of carboxyl group and C=C double bond in rosin resin acid. Through the esterification reaction, Diels-Alder reaction, hydrogenation reaction or oxidation reaction of these two parts, rosin deep processing products can be obtained, and resin acid can also be used to The carboxyl group introduced into the acrylate group is used as a monomer for free radical polymerization to further obtain a rosin-based polymer, which is used in many fields such as coatings, drug slow-release materials, and adhesives. [0003] Polymer microspheres refer to polymer materials or polymer composite materials with diameters ranging from nanometers to micrometers and spherical or ot...

Claims

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Application Information

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IPC IPC(8): C08F122/14C08F2/12
Inventor 李光华李阳段文贵赵治巨
Owner GUANGXI UNIV
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