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Mycelium extract for helicobacter pylori-resistant biological medicine and preparation technology thereof

A technology of Helicobacter pylori and extract, applied in the field of biopharmaceuticals, can solve problems such as contamination of susceptible bacteria

Active Publication Date: 2015-07-08
HUNAN XINHUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are defects in solid fermentation, and it is easy to be contaminated by bacteria. Now the research on solid fermentation technology is a domestic research hotspot. The main research directions are aseptic culture, secondary culture, inhibition of bacteria, and the implementation of two-way solid fermentation technology using Chinese medicinal materials as a nutrient base. Breakthrough The bottleneck of solid fermentation technology, realizing the large-scale industrialization of biomedical bacteria
[0008] At present, screening and discovering active ingredients from higher fungi and their cultures, and applying them to anti-tumor, anti-virus, diabetes, etc., has not only become the development direction of national key research new drugs, but also a hot spot in the development of biomedicine in various countries in the world today. There is no report that screens and discovers active ingredients from medicinal fungi and applies them to anti-Helicobacter pylori

Method used

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  • Mycelium extract for helicobacter pylori-resistant biological medicine and preparation technology thereof
  • Mycelium extract for helicobacter pylori-resistant biological medicine and preparation technology thereof
  • Mycelium extract for helicobacter pylori-resistant biological medicine and preparation technology thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0047] A biomedicinal mycelium extract against Helicobacter pylori, the extract is prepared as follows:

[0048] (1) Take the Hericium erinaceus culture and extract it with 50% ethanol by reflux for 1 hour, then centrifuge at 4000r / min for 8 minutes to remove the dregs to obtain the extract. Among them, the Hericium erinaceus during reflux extraction The weight ratio of culture to ethanol is 1:3;

[0049] (2) Rotate the extract at 50°C until there is no alcohol, add water to precipitate the precipitate, and then centrifuge at 4000r / min for 8min, and dry the precipitate at -60°C to obtain anti-Helicobacter pylori Biomedicine mycelium extract.

Embodiment 2

[0051] A biomedicinal mycelium extract against Helicobacter pylori, the extract is prepared as follows:

[0052] (1) Take the Hericium erinaceus culture and extract it with 40% ethanol at a volume percentage of 40% by reflux for 3 hours, and then centrifuge for 58 min at 4000r / min to remove the dregs to obtain the extract. Among them, the Hericium erinaceus during reflux extraction The weight ratio of culture to ethanol is 1:10;

[0053] (2) Rotate the extract at 50°C until there is no alcohol, add water to precipitate the precipitate, and then centrifuge at 4000r / min for 8min, and dry the precipitate at -40°C to obtain anti-Helicobacter pylori Biomedicine mycelium extract.

Embodiment 3

[0055] A biomedicinal mycelium extract against Helicobacter pylori, the extract is prepared as follows:

[0056] (1) Take the Hericium erinaceus culture and extract the Hericium erinaceus by refluxing with 80% ethanol for 2h, and then centrifuge for 8 min at 4000r / min to remove the dregs to obtain the extract. Among them, the Hericium erinaceus The weight ratio of culture to ethanol is 1:6;

[0057] (2) Rotate the extract at 80°C until there is no alcohol, add water to precipitate the precipitate, then centrifuge at 4000r / min for 8 minutes, and dry the precipitate at -60°C to obtain anti-Helicobacter pylori Biomedicine mycelium extract.

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Abstract

The invention discloses mycelium extract for a helicobacter pylori-resistant biological medicine and a preparation technology thereof. Hericium erinaceus culture is subjected to reflux-extraction by ethanol having a volume concentration of 40 to 80%; extracting solution is subjected to rotary evaporation at a temperature of 30 to 80 DEG C; and the evaporation products are added with water and precipitates are separated out. The mycelium extract breaks the principle that the prior art mainly utilizes common antibiotics such as amoxicillin, gentamycin, clarithromycin and amoxicillin and an auxiliary acid-inhibition agent (such as a bismuth agent) to treat helicobacter pylori-caused infection, and has obvious treatment effects and small side-effect.

Description

Technical field [0001] The invention belongs to the technical field of biopharmaceuticals, and specifically relates to biomedicinal mycelium, and its extract has good anti-helicobacter pylori effect. Background technique [0002] Helicobacter pylori is a spiral-shaped, micro-anaerobic bacteria that requires very strict growth conditions. It was successfully isolated from the gastric mucosal biopsy tissue of a patient with chronic active gastritis in 1983. It is the only microorganism species known to survive in the human stomach. Helicobacter pylori disease includes gastritis caused by Helicobacter pylori infection, peptic ulcer, lymphoproliferative gastric lymphoma, etc. The poor prognosis of Helicobacter pylori is gastric cancer. [0003] Helicobacter pylori is parasitic in the gastric mucosa. 67%-80% of gastric ulcers and 95% of duodenal ulcers are caused by Helicobacter pylori. The common symptoms of patients with chronic gastritis and peptic ulcer are: fullness, discomfort ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/06A61P31/04
Inventor 何述金谭桂山常耀台
Owner HUNAN XINHUI PHARMA
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