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A kind of fluorescent probe compound and its preparation method and use

A technology of fluorescent probes and compounds, which is applied in the field of fluorescent probe compounds and their preparation and application, can solve problems such as application limitations, high detection costs, and complex sample pretreatment processes, and achieve high selectivity, high sensitivity, and low analysis costs. cheap effect

Inactive Publication Date: 2016-09-28
CHANGZHOU JINTAN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Traditional palladium detection methods usually include atomic absorption spectrometry, plasma emission spectrometry, solid-phase microextraction-high performance liquid chromatography, X-ray fluorescence method, etc., but these methods often require complex sample pretreatment processes and special procedures. Trained personnel operate, and the detection cost is high, so the application is greatly limited

Method used

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  • A kind of fluorescent probe compound and its preparation method and use
  • A kind of fluorescent probe compound and its preparation method and use
  • A kind of fluorescent probe compound and its preparation method and use

Examples

Experimental program
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Effect test

Embodiment 1

[0028] In a dry 50ml round bottom flask, add 4-formylfluorescein (formula B) (0.36g, 1mmol) and anhydrous acetonitrile (15.0mL), stir to dissolve with a magnetic stirrer, and then add 2-aminobenzene dropwise Diphenylphosphine (DPPA) (0.305 g, 1.1 mmol) in acetonitrile (15 mL). After the addition, the reaction was carried out at room temperature for 24 hours. A large amount of white precipitates were produced during the reaction. The white solid product produced by the reaction was obtained by suction filtration, which was washed twice with acetonitrile and diethyl ether respectively. The above solid product was recrystallized with 5 mL of dichloromethane / petroleum ether (1:5, volume ratio) to obtain 0.485 g of white powder pure product (A), yield: 78%.

[0029] Preparation of standard working curve:

[0030] Dissolve 7.19 mg of the fluorescent probe (A) prepared above in a 1:1 (volume ratio) aqueous solution of 1 mL of water and dimethylformamide to make 1×10 -2 M is a color...

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Abstract

The invention discloses a fluorescent probe compound and its preparation method and use. The fluorescent probe compound has a general formula A, wherein in the general formula A, X1 and X2 respectively represent H and Cl. The fluorescent probe compound has high selectivity, high sensitivity and strong practicality and provides an important approach for fluorescent signal enhancement analysis of small and trace amounts of palladium compounds.

Description

technical field [0001] The invention relates to a fluorescent probe compound and its preparation method and application. Background technique [0002] Palladium materials and palladium compounds play an important role in the field of materials and chemical catalytic synthesis. Palladium metal materials are widely used in dental materials, gasoline combustion catalysts, electronic products and jewelry; various palladium compounds are excellent catalysts in the synthesis of fine chemicals It has been widely used in drug synthesis. As a sulfur-philic rare transition metal, palladium compounds have serious harmful effects on human health because they can bind to biomacromolecules such as amino acids, sulfur proteins, and DNA in organisms. Recent studies have demonstrated that palladium compounds can even catalyze the Suzuki-Miyaura reaction in living cells [R.M.Yusop, A.Unciti-Broceta, E.M.V.Johansson, R.M.Sánchez-Martín and M.Bradley, Na t.Chem.2011, 3, 239.]. Foreign govern...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F9/6561C09K11/06G01N21/64G01N33/52
Inventor 曾宪顺
Owner CHANGZHOU JINTAN BIOTECH CO LTD