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Method for initiating droplet fusion by liquid infiltration

A droplet and liquid technology, applied in chemical instruments and methods, chemical/physical/physicochemical processes, chemical/physical processes, etc., can solve the problems of complex droplet control process, high production cost, and damage to active substances in the production process , to achieve the effect of cost saving, simple operation and broadening the scope of application

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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This method can accurately achieve one-to-one fusion, but the fabrication process of the microfluidic device and the control process of the droplets are quite complicated, the production cost is too high, and it is only suitable for chargeable systems, and the external electric field may affect the droplets. active substances contained in the

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  • Method for initiating droplet fusion by liquid infiltration
  • Method for initiating droplet fusion by liquid infiltration
  • Method for initiating droplet fusion by liquid infiltration

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Experimental program
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Effect test

Embodiment 1

[0050] In this embodiment, liquid infiltration triggers the fusion of different droplets to achieve micro-mixing. The process steps are as follows:

[0051] (1) Prepare dispersed water phase, intermediate oil phase and continuous phase fluid

[0052] Preparation of the first dispersed water phase fluid: add sodium dodecyl sulfate (SDS) into deionized water at normal pressure and room temperature and stir evenly to form the first dispersed water phase fluid, the mass ratio of the SDS to deionized water is 0.01: 1;

[0053] The preparation of the second dispersed water phase fluid: at normal pressure, at room temperature, SDS, methylene blue are added to deionized water and stirred to form the second dispersed water phase fluid, the mass ratio of the SDS and deionized water is 0.01: 1, the described The amount of methylene blue is 2 mg per 1 ml of deionized water;

[0054] Preparation of intermediate oil phase fluid: add polyricinoleic acid glyceride (PGPR 90) and Lumogen? F R...

Embodiment 2

[0068] In this embodiment, liquid infiltration triggers the fusion of different droplets to achieve micro-mixing. The process steps are as follows:

[0069] (1) Prepare dispersed water phase, intermediate oil phase and continuous phase fluid

[0070] Preparation of the first dispersed water phase fluid: add SDS to deionized water at normal pressure and room temperature and stir evenly to form the first dispersed water phase fluid, the mass ratio of the SDS to deionized water is 0.005: 1;

[0071] Preparation of the second dispersed water phase fluid: add SDS to deionized water at normal pressure and room temperature and stir evenly to form the second dispersed water phase fluid, the mass ratio of the SDS to deionized water is 0.01: 1;

[0072] Preparation of the intermediate oil phase fluid: Add PGPR 90 into medical soybean oil at normal pressure and room temperature and stir evenly to form an intermediate oil phase fluid, the amount of PGPR 90 is 0.01 g per 1 ml of medical so...

Embodiment 3

[0080] In this embodiment, liquid infiltration triggers the fusion of different droplets to achieve micro-mixing. The process steps are as follows:

[0081] (1) Prepare dispersed water phase, intermediate oil phase and continuous phase fluid

[0082] Preparation of the first dispersed water phase fluid: add SDS to deionized water at normal pressure and room temperature and stir evenly to form the first dispersed water phase fluid, the mass ratio of the SDS to deionized water is 0.01:1;

[0083] Preparation of the second dispersed water phase fluid: add SDS to deionized water at normal pressure and room temperature and stir to form a second dispersed water phase fluid, the mass ratio of the SDS to deionized water is 0.005: 1;

[0084] Preparation of the intermediate oil phase fluid: add PGPR 90 into medical soybean oil at normal pressure and room temperature and stir evenly to form an intermediate oil phase fluid, the amount of PGPR 90 is 0.04 g per 1 ml of medical soybean oil;...

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Abstract

The invention belongs to the field of droplet fusion, and particularly relates to a method for initiating different monodisperse droplet fusion by utilizing liquid wettability. The method comprises the processing steps of: (1) preparing disperse water phase, medium oil phase and continuous phase liquid; (2) injecting each disperse phase liquid into a micro-fluidic device to form water-in-oil emulsion droplets and oil-pocket water-in-oil emulsion droplets, enabling the formed water-in-oil emulsion droplets and the oil-pocket water-in-oil emulsion droplets to enter a collecting tube along with the continuous phase fluid; paving oil layers at the surfaces of the oil-pocket water-in-oil emulsion droplets at the surfaces of the water-in-oil emulsion droplets when the water-in-oil emulsion droplets contact the oil-pocket water-in-oil emulsion droplets in an expanded chamber of the collecting tube; and discharging the oil layers between water drops in the oil-pocket water-in-oil emulsion droplets and the water drops in the water-in-oil emulsion droplets, wherein the water drops in the two droplets are fused to achieve micro-mixing or micro-reaction; and (3) collecting the fused droplets.

Description

technical field [0001] The invention belongs to the field of droplet fusion, and in particular relates to a method for using liquid wettability in a microchannel to trigger the fusion of different monodisperse droplets to realize micromixing or microreaction. Background technique [0002] A microreactor is a micro-reaction container that realizes the reaction process by controlling the mixing of trace reagents in a microchannel. Compared with conventional reaction vessels (such as flasks, etc.), microreactors have higher specific surface areas. For example, the specific surface area of ​​a microreactor channel with a width of 100 μm is about 200 times that of a 100 mL flask. Therefore, the microreactor is more conducive to the diffusion of molecules and the transfer of energy, which can make the chemical reaction faster and more efficient. The microreaction requires less reagents, is basically pollution-free, has better safety, and is low in cost. Therefore, the development...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J19/00
Inventor 邓楠楠褚良银汪伟巨晓洁谢锐D·A·威茨
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