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Porous titanium microsphere bone filling material

A filling material, porous titanium technology, applied in the field of biomedical materials, can solve the problems of insufficient osteoconductivity and osteoinductivity, achieve ideal bone enhancement and biological healing, excellent osteoconduction and osteoinductive properties, and benefit The effect of bone cell adhesion

Inactive Publication Date: 2013-08-21
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

None of the bone filling materials currently in clinical use can meet all the above conditions, but only part of the above conditions. The same is true for the materials described in the above patents, and their performance in terms of osteoconductivity and osteoinductivity is still insufficient.

Method used

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  • Porous titanium microsphere bone filling material
  • Porous titanium microsphere bone filling material
  • Porous titanium microsphere bone filling material

Examples

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Effect test

Embodiment 1

[0029] A medical titanium wire with a diameter of 1 mm is used to prepare porous titanium microspheres with a porosity of 42% and a diameter of 10 mm. After sintering at 1200 ° C, a layer of titanium oxide coating is electrochemically coated on the surface. The coating has a porous structure. , the coating thickness is about 20 microns, this kind of porous titanium microspheres has relatively high compressive strength and elastic modulus, and is suitable for bone repair occasions that require high strength.

Embodiment 2

[0031] A medical titanium wire with a diameter of 0.50 mm is used to prepare porous titanium microspheres with a porosity of 90% and a diameter of 3.0 mm. After sintering at 1300 ° C, a ceramic coating compounded with calcium and phosphorus is coated on the surface by an electrochemical method. The coating has Porous structure, the thickness of the coating is about 20 microns, and the calcium and phosphorus in the coating are helpful for bone ingrowth. The porous titanium microspheres have relatively high osteoinductive ability and are suitable for bone repair occasions that require high bone ingrowth.

Embodiment 3

[0033] Using medical titanium fibers with a diameter of 0.05 mm, porous titanium microspheres with a porosity of 20% and a diameter of 1 mm were prepared. After sintering at 1250 ° C, a layer of hydroxyapatite-like coating was electrochemically coated on the surface. layer loaded with anticancer factors. The porous titanium microspheres have the effect of inhibiting the growth of cancer cells and are suitable for bone filling and repairing applications in cancer patients.

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Abstract

The invention discloses a porous titanium microsphere bone filling material. The porous titanium microsphere bone filling material comprises a porous titanium microsphere which is formed by rolling titanium filaments, wherein perforated pore spaces are arranged among the titanium filaments. The bone filling material also comprises a biological active coating of a porous structure, which is covered on the surfaces of the titanium filaments in the porous titanium microsphere, wherein the biological active coating is a ceramic coating of titanium oxide porcelain, composite calcium and phosphorus or a similar hydroxyapatite coating. The porous titanium microsphere bone filling material disclosed by the invention is capable of obviously promoting new bone to grow, the ideal bone strengthening and biological healing are achieved, the porous titanium microsphere bone filling material has excellent bone conduction and bone induction characteristics, and the majority of bone defect fill and restoration are met.

Description

technical field [0001] The invention relates to a medical material for filling and repairing bone defects, in particular to a porous titanium microsphere bone filling material, which belongs to the technical field of biomedical materials. Background technique [0002] At present, the surgical treatment of osteoporosis, fractures and other diseases mostly uses bone cement (PMMA) as filling repair material, because it has the advantages of rapid curing, high mechanical strength, and injectability, but it also has unavoidable disadvantages and risks: ( 1) Heat is released during curing, and its temperature can reach 40-100°C, resulting in varying degrees of necrosis of surrounding bone tissue, and may damage adjacent blood vessels and nerve tissue; (2) Poor biocompatibility, does not mix with surrounding bone tissue in vivo Biological combination occurs, and it is difficult to degrade. The cured PMMA is hard and brittle, with a high elastic modulus, which is easy to cause atrop...

Claims

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Application Information

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IPC IPC(8): A61L27/54A61L27/56A61L27/06A61L27/10A61L27/12
Inventor 何国郝永强
Owner SHANGHAI JIAO TONG UNIV