Preparation method of flurbiprofen axetil

The technology of flurbiprofen axetil and flurbiprofen axetil is applied in the field of preparation of pharmaceutical grade flurbiprofen axetil, and can solve the problems of complicated preparation operation, unfavorable unification of quality standards of preparation raw materials and product, increase of preparation production cost and the like.
CN103254075AActive Publication Date: 2013-08-21WUHAN DOCAN PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WUHAN DOCAN PHARMA
Publication Date
2013-08-21

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Abstract

The invention relates to a preparation method of flurbiprofen axetil. The method comprises the following steps: carrying out a reaction between flurbiprofen and bromoethyl acetate in the presence of a catalyst and a solvent; washing reaction products and separating grease; carrying out underpressure distillation; dissolving a fraction in an organic solvent, washing and drying; and removing the solvent. Purity of flurbiprofen axetil prepared by the method can reach more than 99.0%.
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Description

technical field

[0001] The invention relates to the technical field of pharmacy, in particular to a preparation method of pharmaceutical grade flurbiprofen axetil. Background technique

[0002] Flurbiprofen axetil (Flurbiprofen Axetil) is a non-steroidal anti-inflammatory drug, and its commonly used preparation is flurbiprofen axetil (lipid microspheres) injection, which is a targeted drug delivery preparation and is used clinically in surgery and cancer pain relief.

[0003] In order to reduce the unnecessary side effects brought by the impurities in the raw materials of flurbiprofen axetil, the flurbiprofen axetil as the raw material used in common preparations requires high purity. At present, the commercially available flurbiprofen axetil is of industrial grade, and its purity cannot reach 99.0%, which is not suitable for direct use in the preparation of pharmaceutical preparations, especially injections. Therefore, it is necessary to carry out additional purification ...

Claims

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