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Preparation method of molecular imprinted polymer membrane by means of grafting rejection

A polymer membrane, molecular imprinting technology, applied in chemical instruments and methods, membrane technology, semi-permeable membrane separation, etc., can solve the problems of difficult to deploy template distribution, low imprinting efficiency, and small membrane flux.

Inactive Publication Date: 2013-09-18
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the deficiencies of the existing technology, the technical problem to be solved by the present invention is that it is difficult to adjust the distribution of templates in the process of molecular imprinting, it is difficult to control the optimal ratio of functional monomers and templates, the imprinting efficiency is low, and the membrane flux is small, etc.
[0008] The technical solution of the present invention to solve the problems of difficulty in adjusting the distribution of templates in the molecular imprinting process, difficulty in controlling the optimal ratio of functional monomers and templates, low imprinting efficiency, and small membrane flux is to design a intercepting graft Method for preparing molecularly imprinted polymer membranes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1. A method for preparing bovine serum albumin molecularly imprinted polyacrylamide grafted polysulfone membrane by interception grafting

[0022] a) Dissolve acrylamide, N,N'-methylenebisacrylamide, bovine serum albumin and polyethylene glycol in deionized water to form acrylamide with a mass percentage of 30%, N,N'-methylene The mass percentage of bisacrylamide is 0.001%, the mass percentage of bovine serum albumin is 10%, and the mixture solution is 5% of the porogen. By dropping dilute hydrochloric acid and sodium hydroxide solution, the pH value of the mixture solution is adjusted to 4.8, make acrylamide and bovine serum albumin form a stable complex, place the complex in an airtight container at 4°C for later use, use a nano-laser particle size analyzer to detect the pH of the complex formed by acrylamide and bovine serum albumin =4.8 particle size;

[0023] b) according to step a) test the particle size of the complex formed by acrylamide and bovine seru...

Embodiment 2

[0026] Example 2. A method of intercepting grafting to prepare lysozyme molecularly imprinted polyacrylic acid / polyacrylamide grafted polyvinylidene fluoride membrane

[0027] a) Dissolve acrylic acid, acrylamide, N, N'-methylenebisacrylamide, lysozyme and polyethylene glycol in deionized water to form acrylic acid with a mass percentage of 2%, acrylamide with a mass percentage of 5%, N , N'-methylenebisacrylamide mass percentage is 1%, lysozyme mass percentage is 10%, polyethylene glycol mass percentage is the mixture solution of 0.01%, the pH value of this mixture solution is adjusted by dropping dilute hydrochloric acid 3.8, make acrylic acid, acrylamide and lysozyme form a stable complex, place the complex in an airtight container at 4°C for later use, use a nano-laser particle size analyzer to detect the pH of the complex formed by acrylamide and lysozyme =3.8 particle size;

[0028] b) according to step a) test the particle size of the complex formed by acrylamide and l...

Embodiment 3

[0031] Example 3. A method for preparing DNA molecularly imprinted polymethacrylamide grafted polyvinylidene fluoride membrane by intercepting grafting

[0032] a) Dissolve methacrylamide, divinylbenzene, DNA and polyvinylpyrrolidone in deionized water to form 15% by mass of methacrylamide, 0.5% by mass of divinylbenzene and 0.5% by mass of DNA. 0.5%, a mixture solution of 1% polyvinylpyrrolidone mass percentage, so that methacrylamide and DNA form a stable complex, the complex is placed in a closed container at 0 ° C for standby, and the nanometer laser particle size analyzer is used Detect the particle size of the complex formed by methacrylamide and DNA;

[0033] b) according to step a) test the particle size of the complex formed by methacrylamide and DNA, select the polydene tetrafluoroethylene ultrafiltration membrane with a molecular weight cut-off of 8000 as the base membrane, and clean the surface of the membrane with absolute ethanol and the impurities in the membra...

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Abstract

The invention provides a preparation method of a molecular imprinted polymer membrane by means of grafting rejection. The preparation method comprises the following steps of: preparing a solution of a complex of a functional monomer, a cross-linking agent and a template in a proper proportion, filtering the complex solution by selecting a proper support membrane to reject the complex formed from the functional monomer and the template on the surface of the membrane, selectively filtering out and washing off the functional monomer which does not react with the template to form the stable complex by use of a solvent, grafting a layer of molecular imprinted polymer on the surface of the membrane by means of radiation initiation, and removing the template and an unreacted substance by means of backwashing to obtain the surface grafted molecular imprinted polymer membrane. The molecular imprinted polymer membrane not only keeps the quite large flux and mechanical performance of a carrier membrane, but also is conductive to the elution and recombination of the template, and therefore has excellent application prospect in the fields of chemical separation, solid phase extraction, membrane sensors and the like; the obtained MIP (Molecular Imprinted Polymer) membrane is quite high in imprinting efficiency.

Description

technical field [0001] The invention relates to a method for preparing a molecularly imprinted polymer membrane by intercepting grafting, and belongs to the fields of functional materials, polymer materials and membranes. Background technique [0002] Molecularly imprinted polymer (MIP) is a new type of polymer material, which has high specific recognition ability for specific target molecules. Imprinted polymer membranes combine the advantages of membrane separation and molecular imprinting technologies, and endow the membrane with specific molecular recognition, affinity and selective permeability, so it has become a research hotspot in recent years. The synthesis of molecularly imprinted polymer membranes mainly includes the following methods [Macromol Biosci, 2003, 3(9): 487-498]: (1) in-situ polymerization: the imprinted molecules, functional monomers, cross-linking agents and porogenic The agent mixture is poured between two substrates, and the MIP film is obtained by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/18C08J9/26C08F120/56C08F120/54C08F220/56C08F220/06C08F226/06C08F2/48B01D71/78B01D69/10B01D67/00
Inventor 赵孔银冯灵智魏俊富张新新李文瑞
Owner TIANJIN POLYTECHNIC UNIV
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