Lappaconitine sustained release preparation composition and preparation method thereof

Abstract

The invention discloses a lappaconitine sustained release preparation composition and a preparation method thereof. The lappaconitine sustained release preparation composition comprises lappaconitine; acrylic resin II; a slow release matrix selected from hydroxypropyl methylcellulose, ethyl cellulose or methyl cellulose; an adhesive and a filling agent. Characteristics are that, the weight ratio of lappaconitine: acrylic resin II: the slow release matrix is 1:0.01-0.1:0.05-2. The lappaconitine sustained release preparation composition of the invention is capable of delaying the release rate of main ingredients, decreasing the medicine-taking frequency, and improving the compliance of patients. The preparation method of the lappaconitine sustained release preparation composition in high in quality controllability and stability.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to a sustained-release preparation composition of saccharin and a preparation method thereof. technical background [0002] Hoconine is a diterpene alkaloid, currently the commercially available tablets and injections of Hoconine are in the form of hydrobromide, and Hoconine hydrobromide is an amphiphilic compound, easily Soluble in methanol, slightly soluble in water. [0003] Gaowujiasu is a non-narcotic analgesic drug, the analgesic effect is 7 times that of the common analgesic drug aminopyrine, the analgesic effect is equivalent to that of pethidine and morphine, and the analgesic effect lasts longer, and it is even more melodious. Alternative varieties of madow. The anesthetic isomer of Gaoaconitum has a strong anesthetic effect from deep to superficial, and it has been clinically proven that the local anesthetic effect is equivalent to that of cocaine; the nerve conduction ...

AI Technical Summary

Problems solved by technology

However, patients with cancer and other diseases often use analgesic drugs when they feel pain. This on-demand drug delivery method makes the pain not effectively controlled

According to the three-step treatment principle of cancer pain relief, the application of analgesic drugs should be administered on time, not on demand, and the blood drug concentration in the body can maintain the effective blood drug concentration to achieve better analgesic effect. Therefore, for cancer and other diseases Due to the short half-life in the body, the tablets or injections of commercially available high-urinine need frequent administration for a long time to achieve better analgesic effect, which brings great inconvenience to patients and low patient compliance.

The effective time of one application of Gaowujiasu patch can last for 72 hours, effectively improving the patient's compliance, but the patch has a slow onset of action, and it is easy to cause skin irritation if it is pasted on the skin for a long time. Long-term repeated application, the patch skin irritation problem can not be ignored

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